4.7 Article

Palladium catalyzed, heteroatom-guided C-H functionalization in the synthesis of substituted isoquinolines and dihydroisoquinolines

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 55, Pages 7322-7325

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc03165b

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Funding

  1. DST-SERB, India
  2. CSIR-India
  3. IISERB

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A new approach for the functionalization of C-4 of isoquinolines is reported. The method utilizes palladium catalyzed, hetero-atom guided (or electrophilic metalation) direct arylation via regioselective C-H functionalization of dihydroisoquinolines.

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