Article
Multidisciplinary Sciences
Luize G. Lima, Sunyoung Ham, Hyunku Shin, Edna P. Z. Chai, Erica S. H. Lek, Richard J. Lobb, Alexandra F. Muller, Suresh Mathivanan, Belinda Yeo, Yeonho Choi, Belinda S. Parker, Andreas Moller
Summary: Exosomes secreted by cancer cells play a crucial role in metastasis, with cytokines in the tumor microenvironment binding to exosomes and promoting their uptake by specific cell lineages and organs to enhance metastatic dissemination. This interaction between exosomes and cytokines is a key determinant of cancer progression.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Hao Guo, Bao-Tong Mo, Guo-Cheng Li, Zi-Lin Li, Ling-Qiao Huang, Ya-Lan Sun, Jun-Feng Dong, Dean P. Smith, Chen-Zhu Wang
Summary: This study identifies the sex pheromone and elucidates the olfactory basis of sex pheromone communication in Campoletis chlorideae, a parasitoid wasp. It demonstrates the importance of specific receptors in male attraction and mating behavior, and also shows the synergistic effects of the sex pheromone and a female attractant in increasing the parasitic efficiency of the wasp.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Sreelakshmi Radhakrishnan, Karthika S. Nair, Samir Nandi, Harsha Bajaj
Summary: In this study, semi-permeable GUVs were constructed by engineering the composition of DOTAP lipid, allowing control over their size-selective permeability without the need for reconstituting membrane proteins. These semi-permeable GUVs have significant applications in constructing synthetic cells.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biology
Jothi K. Yuvaraj, Rebecca E. Roberts, Yonathan Sonntag, Xiao-Qing Hou, Ewald Grosse-Wilde, Ales Machara, Dan-Dan Zhang, Bill S. Hansson, Urban Johanson, Christer Lofstedt, Martin N. Andersson
Summary: This study annotated 73 ORs from an antennal transcriptome of I. typographus and reported the functional characterization of two ORs (ItypOR46 and ItypOR49) responsive to single enantiomers of common bark beetle pheromone compounds. Homology modeling and molecular docking were used to predict their binding sites, providing insight into ligand-OR interaction for the functional evolution of the insect OR gene family. The ecological importance of these receptors and their potential use in pest control and biosensors to detect bark beetle infestations suggest further evaluation of these ORs.
Article
Chemistry, Multidisciplinary
Stefanie D. Pritzl, Johannes Morstein, Sophia Kahler, David B. Konrad, Dirk Trauner, Theobald Lohmuller
Summary: This study reports the optical control of lipid vesicles through vesicle fusion. It is observed that charge-mediated fusion enhances overall fusion performance and doping efficiency. Additionally, the use of phosphatidylcholine analogs with photo-switches affects the shape and properties of the resulting vesicles.
Article
Biochemical Research Methods
Seren Ohnishi, Koki Kamiya
Summary: This study presents a novel artificial cell model employing the dual functional membrane protein OmpLA for small molecule transportation and small vesicle budding. The orientation of OmpLA was controlled by lipid composition and its enzymatic activity led to budding of small vesicles. Through this mechanism, the transportation of ions or small molecules was achieved for the first time.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Chemistry, Physical
Karthika S. Nair, Neethu B. Raj, K. Madhavan Nampoothiri, Gayathri Mohanan, Silvia Acosta-Gutierrez, Harsha Bajaj
Summary: We successfully constructed giant vesicle models mimicking bacterial inner-membrane and outer-membrane using gel-assisted lipid swelling technique, and observed their membrane deformation behavior under osmotic stress. Inner-membrane vesicles composed of native bacterial lipids underwent small-scale remodeling, while outer-membrane vesicles assembled from lipopolysaccharide and bacterial lipids underwent global membrane deformation, generating complex curved structures.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Maria Joao Moreno, Patricia Alexandra Teles Martins, Eva F. Bernardino, Biebele Abel, Suresh V. Ambudkar
Summary: This study characterized the lipidome and lipid/protein ratio of membranes from High Five™ insect cells overexpressing mouse P-glycoprotein, providing insight into the lipid environment surrounding P-glycoprotein and its properties. Phosphatidylethanolamines were the most abundant phospholipids, followed by phosphatidylcholines. The membranes also contained negatively charged lipids such as phosphatidylserines, phosphatidylinositols, and phosphatidylglycerols.
Article
Chemistry, Multidisciplinary
Yanwen Zhang, Yufeng Chen, Xiaohai Yang, Xiaoxiao He, Mei Li, Songyang Liu, Kemin Wang, Jianbo Liu, Stephen Mann
Summary: The newly developed giant coacervate vesicles (GCVs) can serve as cytomimetic models with high sequestration efficiency and permeability to molecules below a molecular weight cutoff of approximately 4 kDa, suitable for enzyme and ribozyme catalysis reactions.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Keisuke Tanaka, Kenji Shimomura, Akito Hosoi, Yui Sato, Yukari Oikawa, Yuma Seino, Takuto Kuribara, Shunsuke Yajima, Motohiro Tomizawa
Summary: This study analyzed the antennal transcriptome of the cowpea beetle and identified several odorant-related genes. Differential gene expression analysis revealed specific genes expressed in males, providing insights into the olfaction of this major pest.
Article
Food Science & Technology
Feng Jiang, Jingbo Liu, Zhiyang Du, Xuanting Liu, Xiaomin Shang, Yiding Yu, Ting Zhang
Summary: This study investigates the effect of soybean meal peptides on phase separation and reveals the correlation between peptide membrane localization and phase regulation. The results demonstrate that peptides YYK, CLA, and SLW increase the liquid-ordered (Lo) phase while peptide WLQ decreases it. The localization of peptides in the membrane amphiphilic region plays a crucial role in their regulation of phase separation.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Hematology
Stephanie A. Renna, James Michael, Xianguo Kong, Lin Ma, Peisong Ma, Marvin T. Nieman, Leonard C. Edelstein, Steven E. McKenzie
Summary: The study found functional differences between human and mouse PAR4, including responsiveness and signaling pathways, highlighting the importance of considering these differences when interpreting mouse PAR4 studies.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Multidisciplinary Sciences
Michael Neumaier, Sophie Giesler, Volker Ast, Mathis Roemer, Timo-Daniel Voss, Eileen Reinz, Victor Costina, Martin Schmelz, Elina Nuernberg, Stefanie Nittka, Aino-Maija Leppae, Ruediger Rudolf, Andreas Trumpp, Tina Fuchs
Summary: This report introduces a new class of innate immune cells, called VIREMs, which are myeloid cells unrelated to lymphocytes. The researchers found that B-VIREMs, a subtype of VIREMs, have the ability to genetically recombine and express antibody genes, similar to B lymphocytes. They also discovered that B-VIREMs circulate in the blood of healthy individuals and undergo clonal expansion in response to disease stimuli. Live-cell imaging models suggest that B-VIREMs load their own Fc receptors with endogenous antibodies during vesicle transport. The findings suggest that these innate immune cells have important antigen-specific tissue maintenance functions.
Article
Cell Biology
Anna Tokarska, Gilad Silberberg
Summary: The interactions between striatal cholinergic and GABAergic systems play a crucial role in reward-related behavior and reinforcement learning. By studying Chrna2-Cre mice, we discovered that striatal Chrna2-INs have different electrophysiological, morphological, and synaptic properties compared to other brain regions. These INs form inhibitory synaptic connections with striatal projection neurons and other INs and receive excitatory inputs from the primary motor cortex. Some Chrna2-INs respond to nicotinic input, suggesting reciprocal interactions with striatal cholinergic synapses.
Review
Biochemistry & Molecular Biology
Ella L. Johnston, Begona Heras, Thomas A. Kufer, Maria Kaparakis-Liaskos
Summary: BMVs produced by both Gram-negative and Gram-positive bacteria contain immune stimulating molecules that can modulate host immune response through NLR-dependent mechanisms. Commensal derived BMVs are believed to shape immunity and maintain gut homeostasis, highlighting their roles in limiting inflammatory diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Qili Liu, Masashi Tabuchi, Sha Liu, Lay Kodama, Wakako Horiuchi, Jay Daniels, Lucinda Chiu, Daniel Baldoni, Mark N. Wu
Article
Biology
Xiaojun Xie, Masashi Tabuchi, Matthew P. Brown, Sarah P. Mitchell, Mark N. Wu, Alex L. Kolodkin
Article
Chemistry, Analytical
Tomonori Nomoto, Masahiro Takahashi, Takuya Fujii, Luca Chiari, Taro Toyota, Masanori Fujinami
ANALYTICAL SCIENCES
(2018)
Editorial Material
Biochemistry & Molecular Biology
Masashi Tabuchi, Mark N. Wu
Article
Chemistry, Physical
Yuichiro Karasawa, Tomonori Nomoto, Luca Chiari, Taro Toyota, Masanori Fujinami
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2018)
Article
Chemistry, Multidisciplinary
Yasuhito Watahiki, Tomonori Nomoto, Luca Chiari, Taro Toyota, Masanori Fujinami
Article
Biochemistry & Molecular Biology
Masashi Tabuchi, Joseph D. Monaco, Grace Duan, Benjamin Bell, Sha Liu, Qili Liu, Kechen Zhang, Mark N. Wu
Article
Neurosciences
Xiaojun Xie, Masashi Tabuchi, Abel Corver, Grace Duan, Mark N. Wu, Alex L. Kolodkin
Article
Multidisciplinary Sciences
Brian M. Woolums, Brett A. McCray, Hyun Sung, Masashi Tabuchi, Jeremy M. Sullivan, Kendra Takle Ruppell, Yunpeng Yang, Catherine Mamah, William H. Aisenberg, Pamela C. Saavedra-Rivera, Bryan S. Larin, Alexander R. Lau, Douglas N. Robinson, Yang Xiang, Mark N. Wu, Charlotte J. Sumner, Thomas E. Lloyd
NATURE COMMUNICATIONS
(2020)
Review
Clinical Neurology
Masashi Tabuchi, Kaylynn E. Coates, Oscar B. Bautista, Lauren H. Zukowski
Summary: Studies indicate that membrane potential dynamics regulated by photoreceptor and core clock molecules play a crucial role in neural coding, influencing synaptic plasticity, neural firing activity, and light-driven arousal. This mechanism has implications for understanding sleep architecture, memory processing, and neurological disorders.
FRONTIERS IN NEUROLOGY
(2021)
Article
Chemistry, Multidisciplinary
Tomonori Nomoto
Summary: This paper introduces a simple and easily prepared homemade Raman spectroscope, which utilizes low-cost components to test the Raman spectra of various substances, discussing the resolution and detection limit of ethanol aqueous solution. It also mentions the use of the spectroscope in a live-streamed demonstration.
JOURNAL OF CHEMICAL EDUCATION
(2021)
Article
Physiology
Dieu Linh Nguyen, Anelise N. Hutson, Yutian Zhang, Skylar D. Daniels, Aidan R. Peard, Masashi Tabuchi
Summary: Aging disrupts the regulation of sleep quality by affecting neural excitability and patterned spike sequences in circadian clock neurons, and also causes disorganized subcellular localization patterns of key factors involved in regulating spike patterns. These findings suggest that unstructured neural activity in aging clock neurons may contribute to age-related declines in sleep quality.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Margaret C. W. Ho, Masashi Tabuchi, Xiaojun Xie, Matthew P. Brown, Skylar Luu, Serena Wang, Alex L. Kolodkin, Sha Liu, Mark N. Wu
Summary: The mechanisms underlying the accumulation and release of sleep drive in homeostasis are not well understood. In this study using the fruit fly model, researchers identified R5 neurons as potential sleep drive neurons that promote sleep by signaling to EPG neurons. The connectivity between R5 and EPG neurons strengthens with increased sleep need and triggers sleep when a sufficient number of EPG neurons are activated.
Article
Chemistry, Physical
Tomonori Nomoto, Mizuki Marumo, Luca Chiari, Taro Toyota, Masanori Fujinami
Summary: An inclined liquid surface, such as a meniscus, is important for advection and transport phenomena at the liquid's surface. This paper presents a noninvasive method for measuring the interfacial tension and surface flow speed of an inclined water surface. The method uses a closed-loop control system to track scattered and referential light in order to obtain accurate measurements. The results demonstrate the difficulty of accurately measuring the interfacial tension and flow speed of a self-propelled camphor boat on an inclined water surface without dynamic tracking.
JOURNAL OF PHYSICAL CHEMISTRY B
(2023)
Article
Chemistry, Physical
Shoko Uemoto, Taro Toyota, Luca Chiari, Tomonori Nomoto, Masanori Fujinami
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2017)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)