Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 95, Pages 14946-14948Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02578d
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Funding
- KAKENHI [23651231, 25104506, 22000006, 24689003, 24659042, 20117003, 23249004]
- Astellas Foundation for Research on Metabolic Disorders
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Acrolein, a cytotoxic alpha,beta-unsaturated aldehyde and disease biomarker, was determined in plasma by means of a novel tethering strategy using Michael addition of the compound to a fluorescent dye, followed by immobilization of the product on microbeads via the aldehyde moiety. Elevation of blood acrolein was detected in mice treated with an anticancer agent cyclophosphamide, which releases acrolein upon activation. This method should be suitable for high-throughput diagnostic and clinical application.
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