Article
Chemistry, Medicinal
Ahmed Abdelhameed, Mei Feng, April C. Joice, Emilia M. Zywot, Yiru Jin, Chris La Rosa, Xiaoping Liao, Heidi L. Meeds, Yena Kim, Junan Li, Craig A. McElroy, Michael Zhuo Wang, Karl A. Werbovetz
Summary: The development of new drugs is crucial for treating visceral leishmaniasis, and the hybridization approach of arylimidamides and antifungal azoles is promising. Some newly synthesized compounds exhibited better antileishmanial properties against intracellular Leishmania, especially when employing an imidazole ring as the terminal group.
ACS INFECTIOUS DISEASES
(2021)
Article
Chemistry, Physical
Zhifen Li, Ming Tian, Jingbo Ma, Siyu Xia, Xiannian Lv, Peng Xia, Xiaolong Xu, Yuke Jiang, Jigang Wang, Zhijie Li
Summary: Eight bis-chalcone conjugates with lysine linker were synthesized and evaluated for their antiproliferative potential. The derivatives showed good sensitivity against gastric cancer cells TMK1 and AGS, with compound 3a exhibiting the most potent activity. In vivo studies demonstrated that compound 3a effectively inhibited tumor growth in a xenograft model. The mechanism of action of 3a in tumor growth inhibition was further investigated, revealing a positive regulation of apoptotic signaling pathway.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Computer Science, Information Systems
Zinah N. Idan, Sadiq H. Abdulhussain, Basheera M. Mahmmod, Khaled A. Al-Utaibi, Syed Abdul Rahman Al-Hadad, Sadiq M. Sait
Summary: This paper presents a new method for fast video processing in shot boundary detection by selecting candidate segment and separable moments, achieving a balance between accuracy and speed. The proposed algorithm reduces computational cost and disturbance factors, and outperforms existing methods with improvements in frame percentage and transition accuracy percentage. Moreover, a comparative study shows over 38% improvement in computation time compared to state-of-the-art algorithms.
Review
Biology
Wei Xue, Xu-Kai Ma, Li Yang
Summary: The article discusses the diversity of RNA splicing in eukaryotic cells, including non-canonical splicing types such as back splicing and recursive splicing, and their widespread expression in various species. In addition, the characteristics of back splicing and recursive splicing during nascent RNA synthesis are also discussed.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Chemistry, Physical
Olusola John Dahunsi, Bomin Li, Siyuan Gao, Ke Lu, Fan Xia, Tao Xu, Yingwen Cheng
Summary: The study addresses the challenge of high reactivity in Na metal batteries by using a one-step-synthesized Na-Sn alloy anode, resulting in improved stability and capacity retention in cycling performance. The composite Na@Na15Sn4 anode enables stable cycling of symmetric cells and enhances the stability of full cells coupled with Na3V2(PO4)(3) cathodes over 300 cycles.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Chemistry, Medicinal
Tomohiro Kishimura, Takahito Tomori, Yoshiaki Masaki, Kohji Seio
Summary: A variety of 2'-O-alkylcarbamoyl-ethyl modified oligonucleotides were synthesized, showing improved duplex stability and resistance to 3'-exonuclease. These modifications have been proven useful for various biological applications.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Microbiology
Olivia C. Swann, Amalie B. Rasmussen, Thomas P. Peacock, Carol M. Sheppard, Wendy S. Barclay
Summary: To infect humans and cause a pandemic, avian influenza must adapt to use human versions of certain proteins. One critical host protein is ANP32. Understanding how ANP32 supports viral activity may help develop new antiviral strategies. Surprisingly, avian influenza can use human ANP32 for one step of replication, but needs avian ANP32 for another step.
Article
Neurosciences
Hannah R. Monday, Shivani C. Kharod, Young J. Yoon, Robert H. Singer, Pablo E. Castillo
Summary: Learning and memory rely on long-lasting, synapse-specific modifications. This study found that presynaptic FMRP and protein synthesis dynamically control presynaptic structure and function in the mature mammalian brain.
Article
Engineering, Chemical
Andoni Choya, Beatriz de Rivas, Jose Gutierrez-Ortiz, Ruben Lopez-Fonseca
Summary: The catalytic activity of cobalt oxide supported on six ceria supports synthesized by various synthesis methods was studied for complete methane oxidation. The results showed that the supports synthesized by direct calcination and precipitation with ammonia had the best textural and structural properties as well as the highest degree of oxidation. The cobalt deposited on the first two supports had a good dispersion and a higher number of Co3+ ions on their surface.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2022)
Article
Chemistry, Physical
Felipe M. Souza, Thays S. Lima, Paula Bohnstedt, Victor S. Pinheiro, Bruno L. Batista, Luanna S. Parreira, Fabio R. Simoes, Lucia Codognoto, Peter Hammer, Mauro C. Santos
Summary: Pd nanoparticles supported on multilayer graphene exhibited superior performance in the anode of an alkaline direct ethanol fuel cell, showing lower CO oxidation onset potential and better current density, facilitating the oxidation of intermediates.
Article
Engineering, Electrical & Electronic
Pawel Poczekajlo, Krzysztof Wawryn
Summary: In this article, a low sensitivity synthesis algorithm for implementing a non-separable N-D finite impulse response filter in FPGA is proposed. The algorithm utilizes a pipelined structure and orthogonal transfer functions to avoid complex multidimensional equation computation. Experimental results show that the filter has good performance.
IET SIGNAL PROCESSING
(2022)
Article
Chemistry, Multidisciplinary
Sung Won Kim, Yang Il Cho, Kyeong Eun Jung
Summary: This study presents a method to avoid high-pressure issues during oligonucleotide solid-phase synthesis by adding a pre-swelling step before detritylation, leading to improved purity and decreased impurities. The approach also has potential benefits in reducing reaction times, increasing product yield, and enhancing synthesis efficiency.
BULLETIN OF THE KOREAN CHEMICAL SOCIETY
(2021)
Article
Nanoscience & Nanotechnology
Hassan H. Fakih, Johans J. Fakhoury, Danny Bousmail, Hanadi F. Sleiman
ACS APPLIED MATERIALS & INTERFACES
(2019)
Article
Biochemistry & Molecular Biology
Elise Malek-Adamian, Johans Fakhoury, Amy E. Arnold, Saul Martinez-Montero, Molly S. Shoichet, Masad J. Damha
NUCLEIC ACID THERAPEUTICS
(2019)
Article
Multidisciplinary Sciences
Kathrin Hoelz, Angelina Pavlic, Jory Lietard, Mark M. Somoza
SCIENTIFIC REPORTS
(2019)
Article
Chemistry, Multidisciplinary
Erika Schaudy, Mark M. Somoza, Jory Lietard
CHEMISTRY-A EUROPEAN JOURNAL
(2020)
Article
Multidisciplinary Sciences
Philipp L. Antkowiak, Jory Lietard, Mohammad Zalbagi Darestani, Mark M. Somoza, Wendelin J. Stark, Reinhard Heckel, Robert N. Grass
NATURE COMMUNICATIONS
(2020)
Article
Biochemistry & Molecular Biology
Jory Lietard, Adrien Leger, Yaniv Erlich, Norah Sadowski, Winston Timp, Mark M. Somoza
Summary: Nucleic acid microarrays are essential for supplying large oligonucleotide libraries, but understanding of error sources and extent remains limited. Deletion rate is influenced by photolysis yield, synthetic failures stem from coupling cycles, and optical imperfections can also contribute to errors. Precisely quantifying error types can help optimize fabrication parameters and array design.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biochemical Research Methods
Erika Schaudy, Jory Lietard, Mark M. Somoza
Summary: The untemplated activity of terminal deoxynucleotidyl transferase (TdT) is influenced by the nature of the initiating strands, including their length, chemistry, and nucleotide composition. Experimental results show that TdT is also catalytically active on a non-nucleosidic substrate, hexaethylene glycol. These findings provide new insights into constraints and strategies for de novo synthesis of DNA using TdT.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Microbiology
Max Kolton, David J. Weston, Xavier Mayali, Peter K. Weber, Karis J. McFarlane, Jennifer Pett-Ridge, Mark M. Somoza, Jory Lietard, Jennifer B. Glass, Erik A. Lilleskov, A. Jonathan Shaw, Susannah Tringe, Paul J. Hanson, Joel E. Kostka
Summary: The microbiome of Sphagnum mosses in North America shows remarkable consistency, with nitrogen-fixing methanotrophs playing a key role in the coupling of carbon and nitrogen cycles.
Article
Chemistry, Multidisciplinary
Jory Lietard, Dominik Ameur, Mark M. Somoza
Summary: Fluorescein's fluorescence intensity is strongly influenced by its chemical environment, particularly in nucleic acids. This study comprehensively investigates how DNA sequences affect fluorescence intensity and identifies complex changes in fluorescence intensity depending on sequence contexts involving proximity to nucleobases.
Article
Multidisciplinary Sciences
Tadija Kekic, Jory Lietard
Summary: Fluorescence is an ideal tool to observe and manipulate nucleic acids and study their complex biophysical properties. This study comprehensively maps the sequence-dependence of Cy3 and Cy5 dyes in DNA, revealing that G-rich motifs dominate the high fluorescence range.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Erika Schaudy, Jory Lietard
Summary: DNA microarrays are useful tools to study nucleic acid interactions. A novel enzymatic approach is described here to synthesize high-density DNA microarrays with chemical modifications. The method involves photocrosslinking a DNA primer to a standard microarray, extension with a DNA polymerase, and template strand removal with T7 exonuclease. This method allows for the production of surface-bound natural and non-natural DNA oligonucleotides, facilitating the preparation of combinatorial, chemically modified aptamer libraries.
Article
Chemistry, Analytical
Arya Das, Santra Santhosh, Maya Giridhar, Juergen Behr, Timm Michel, Erika Schaudy, Gisela Ibanez-Redin, Jory Lietard, Mark M. Somoza
Summary: This article describes the common use of glass substrates in biomolecular arrays and the modification of glass surfaces using silane chemistry. The study finds that the use of dipodal silanes greatly enhances the stability of arrays compared to standard monopodal silanes, resulting in improved signal and signal-to-noise ratios.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tadija Kekic, Jory Lietard
Summary: Nucleic acid microarray photolithography allows for control of density, throughput, and positioning in DNA synthesis, and introduces an additional layer of control through hybridization affinity. This approach enables the production of a large palette of colors and can be seen as a miniaturized DNA-based painting technique.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Tadija Kekic, Jory Lietard
Summary: This study examines the assembly of 256 shades of green Cy3 fluorescence using the sequence-dependence of the fluorescence properties in commonly used nucleic acid labeling dyes. Microarrays of labeled nucleic acids are synthesized using photolithography, allowing accurate replication of 8-bit monochrome graphics by mapping color to fluorescence intensity and sequence.
Article
Microbiology
Max Kolton, David J. Weston, Xavier Mayali, Peter K. Weber, Karis J. McFarlane, Jennifer Pett-Ridge, Mark M. Somoza, Jory Lietard, Jennifer B. Glass, Erik A. Lilleskov, A. Jonathan Shaw, Susannah Tringe, Paul J. Hanson, Joel E. Kostka
Summary: The study reveals that diazotrophic methanotrophs play a crucial role in the core Sphagnum microbiome, coupling the carbon and nitrogen cycles in nutrient-poor peatlands.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
