Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 86, Pages 13023-13025Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc06516f
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Funding
- National Science Foundation
- Division Of Human Resource Development
- Direct For Education and Human Resources [1311318] Funding Source: National Science Foundation
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The pacidamycin and muraymycin uridyl peptide antibiotics show some structural resemblance to an Arg-Trp-x-x-Trp sequence motif for protein-protein interaction between bacteriophage phi X174 protein E and E. coli translocase MraY. Members of the UPA class, and a synthetic uridine-peptide analogue, were found to show reduced levels of inhibition to F288L or E287A mutant MraY enzymes, implying that the UPAs interact at this extracellular site as part of the enzyme inhibition mechanism.
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