A rapid, site-selective and efficient route to the dual modification of DARPins

Location Matters: Site of Conjugation Modulates Stability and Pharmacokinetics of Antibody Drug Conjugates

(2013) Pavel Strop et al.   CHEMISTRY & BIOLOGY

Catalyst-Free and Site-Specific One-Pot Dual-Labeling of a Protein Directed by Two Genetically Incorporated Noncanonical Amino Acids

(2012) Bo Wu et al.   CHEMBIOCHEM

Macromolecular Ligands for Gadolinium MRI Contrast Agents

(2012) Yang Li et al.   MACROMOLECULES

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

A “Tag-and-Modify” Approach to Site-Selective Protein Modification

(2011) Justin M. Chalker et al.   ACCOUNTS OF CHEMICAL RESEARCH

One-Pot Dual-Labeling of a Protein by Two Chemoselective Reactions

(2011) Long Yi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Facile Double-Functionalization of Designed Ankyrin Repeat Proteins using Click and Thiol Chemistries

(2011) Manuel Simon et al.   BIOCONJUGATE CHEMISTRY

Bromopyridazinedione-mediated protein and peptide bioconjugation

(2011) Vijay Chudasama et al.   CHEMICAL COMMUNICATIONS

Bispecific Designed Ankyrin Repeat Proteins (DARPins) Targeting Epidermal Growth Factor Receptor Inhibit A431 Cell Proliferation and Receptor Recycling

(2011) Ykelien L. Boersma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Choosing an effective protein bioconjugation strategy

(2011) Nicholas Stephanopoulos et al.   Nature Chemical Biology

Structural Determinants for Improved Stability of Designed Ankyrin Repeat Proteins with a Redesigned C-Capping Module

(2010) Michaela A. Kramer et al.   JOURNAL OF MOLECULAR BIOLOGY

Encoding multiple unnatural amino acids via evolution of a quadruplet-decoding ribosome

(2010) Heinz Neumann et al.   NATURE

A series of PDB related databases for everyday needs

(2010) R. P. Joosten et al.   NUCLEIC ACIDS RESEARCH

Electrophilic Affibodies Forming Covalent Bonds to Protein Targets

(2009) Lotta Holm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

DARPins as Bispecific Receptor Antagonists Analyzed for Immunoglobulin E Receptor Blockage

(2009) Alexander Eggel et al.   JOURNAL OF MOLECULAR BIOLOGY

Site-Specific N- and C-Terminal Labeling of a Single Polypeptide Using Sortases of Different Specificity

(2009) John M. Antos et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Site-Specific Two-Color Protein Labeling for FRET Studies Using Split Inteins

(2009) Jin-Yi Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibody-Drug Conjugates for Cancer Therapy

(2008) Paul J. Carter et al.   CANCER JOURNAL

Folding and Unfolding Mechanism of Highly Stable Full-Consensus Ankyrin Repeat Proteins

(2007) Svava K. Wetzel et al.   JOURNAL OF MOLECULAR BIOLOGY

Characterization and Further Stabilization of Designed Ankyrin Repeat Proteins by Combining Molecular Dynamics Simulations and Experiments

(2007) Gianluca Interlandi et al.   JOURNAL OF MOLECULAR BIOLOGY