Article
Chemistry, Inorganic & Nuclear
Ina Hierlmeier, Amaury Guillou, Daniel F. Earley, Anthony Linden, Jason P. Holland, Mark D. Bartholomae
Summary: In this study, we synthesized and investigated the coordination chemistry of novel copper(II) and zinc(II) complexes using two heterocyclic triazacyclononane(tacn)-based chelators (HNODThia and NODThia-AcNHEt). The modified chelator HNODThia was used to develop a PSMA-based bioconjugate (NODThia-PSMA) and a photoactivatable azamacrocyclic analogue (NODThia-PEG ( 3 ) -ArN ( 3 )) for copper-64 radiopharmaceuticals. The metal-binding chelates showed rapid radiolabeling, stability in human plasma, and successful photoconjugation to albumin and antibodies. These findings have significant implications for the development of stable Cu-64-based radiopharmaceuticals and the future application of Cu-67 in targeted radioimmunotherapy.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Santosh Kumar Sahu, Prabhupada Choudhury, Pradyota Kumar Behera, Tanmayee Bisoyi, Rashmi Ranjan Sahu, Abinash Bisoyi, Koteswara Rao Gorantla, Bhabani S. Mallik, Manoj Mohapatra, Laxmidhar Rout
Summary: The study presents a new protocol for Sonogashira cross-coupling reaction using the cheap and commercially available CuSeO3·2H2O catalyst, resulting in high yields of products under mild conditions without the need for ligands. This marks the first use of an oxygen-bridged copper-based bimetallic catalyst for C-sp-C-sp2 Sonogashira cross-coupling reactions under mild conditions, demonstrating a palladium-free reaction up to a limit of 0.2 ppm.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Ipek Atik
Summary: In this study, a YOLOv5-based Cross convolution with BottleneckCSP (CB-YOLOv5) model is proposed for drone detection. The model utilizes Bottleneck CSP and cross convolution module to enhance accuracy and inference speed, and its effectiveness is validated through comparison with other techniques.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2023)
Article
Chemistry, Medicinal
Helen Damerow, Bjoern Waengler, Ralf Schirrmacher, Gert Fricker, Carmen Waengler
Summary: Different chelators can be used to introduce [Ga-68]Ga3+ into receptor-specific peptidic carriers for radiotracer imaging, and the choice of chelating agent significantly affects the in vivo pharmacokinetics of the radiopeptides. A backbone-functionalized variant of the chelator CB-DO2A, CB-DO2A-GA, was developed as a valuable alternative to established chelating agents for Ga-68-radiolabeling of peptides. It was found that CB-DO2A-GA required harsher reaction conditions for Ga-68-incorporation compared to DOTA, NODA-GA, and DOTA-GA.
Article
Polymer Science
Niccolo Braidi, Mirko Buffagni, Valentina Buzzoni, Franco Ghelfi, Francesca Parenti, Maria Letizia Focarete, Chiara Gualandi, Elena Bedogni, Luisa Bonifaci, Gianfranco Cavalca, Angelo Ferrando, Aldo Longo, Ida Morandini, Nicolo Pettenuzzo
Summary: An anomalous polystyrene gel was obtained during the copper-catalyzed activators regenerated by electron transfer atom transfer radical polymerization (ARGET ATRP) of styrene at 60-70 degrees C, using ascorbic acid/Na2CO3 as the reducing system and EtOAc/EtOH as the solvent mixture. The phenomenon of anomalous PS branching is closely related to reaction conditions such as temperature and the use of a bifunctional initiator, and the intensity of branching/cross-linking can be influenced by the presence of Cu-II or the chain polymerization rate.
MACROMOLECULAR RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Mohammad Ali Nasseri, Mansoore Shahabi, G. Seyyedeh Ameneh Alavi, Ali Allahresani
Summary: A novel Fe3O4@SiO2@Cyt-Ni/Cu nanocomposite catalyst was synthesized and showed efficient performance for Sonogashira and C-N cross-coupling reactions. The catalyst was characterized by various techniques and the geometry optimization and relative energies of the designed bimetallic complexes were theoretically determined. The catalyst exhibited good activity in coupling reactions and could be easily recovered and reused multiple times with minimal loss of catalytic activity.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jessie R. Nedrow, Joseph D. Latoche, Kathryn E. Day, Jalpa Modi, Tanushree Ganguly, Dexing Zeng, Brenda F. Kurland, Clifford E. Berkman, Carolyn J. Anderson
MOLECULAR IMAGING AND BIOLOGY
(2016)
Article
Medicine, Research & Experimental
Wissam Beaino, Jessie R. Nedrow, Carolyn J. Anderson
MOLECULAR PHARMACEUTICS
(2015)
Article
Oncology
Su-Hyeong Kim, Eun-Ryeong Hahm, Julie A. Arlotti, Suman K. Samanta, Michelle B. Moura, Stephen H. Thorne, Yongli Shuai, Carolyn J. Anderson, Alexander G. White, Anna Lokshin, Joomin Lee, Shivendra V. Singh
BREAST CANCER RESEARCH AND TREATMENT
(2016)
Article
Chemistry, Inorganic & Nuclear
Yongkang Gai, Lingyi Sun, Wenqi Hui, Qin Ouyang, Carolyn J. Anderson, Guangya Xiang, Xiang Ma, Dexing Zeng
INORGANIC CHEMISTRY
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Deepti Soodgupta, Haiying Zhou, Wissam Beaino, Lan Lu, Michael Rettig, Mark Snee, James Skeath, John F. DiPersio, Walter J. Akers, Richard Laforest, Carolyn J. Anderson, Michael H. Tomasson, Monica Shokeen
JOURNAL OF NUCLEAR MEDICINE
(2016)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhengxin Cai, Neale Scott Mason, Carolyn J. Anderson, Wilson Barry Edwards
NUCLEAR MEDICINE AND BIOLOGY
(2016)
Review
Multidisciplinary Sciences
Carolyn J. Anderson, Jason S. Lewis
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2017)
Article
Medicine, Research & Experimental
Cindy J. Choy, Xiaoxi Ling, Jonathan J. Geruntho, Sophia K. Beyer, Joseph D. Latoche, Beatrice Langton-Webster, Carolyn J. Anderson, Clifford E. Berkman
Article
Oncology
Masahiro Kikuchi, David A. Clump, Raghvendra M. Srivastava, Lingyi Sun, Dexing Zeng, Julio A. Diaz-Perez, Carolyn J. Anderson, W. Barry Edwards, Robert L. Ferris
Article
Biochemical Research Methods
Emre Demirci, Rafay Ahmed, Meltem Ocak, Joseph Latoche, April Radelet, Nicole DeBlasio, N. Scott Mason, Carolyn J. Anderson, James M. Mountz
Article
Multidisciplinary Sciences
Lixiong Dai, Chloe M. Jones, Wesley Ting Kwok Chan, Tiffany A. Pham, Xiaoxi Ling, Eric M. Gale, Nicholas J. Rotile, William Chi-Shing Tai, Carolyn J. Anderson, Peter Caravan, Ga-Lai Law
NATURE COMMUNICATIONS
(2018)
Article
Acoustics
Qiyang Chen, Jaesok Yu, Lyudmila Lukashova, Joseph D. Latoche, Jianhui Zhu, Linda Lavery, Konstantinos Verdelis, Carolyn J. Anderson, Kang Kim
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2020)
Article
Hematology
Lydia A. Perkins, Lea Nyiranshuti, Lynda Little-Ihrig, Joseph D. Latoche, Kathryn E. Day, Qin Zhu, Sina Tavakoli, Prithu Sundd, Enrico M. Novelli, Carolyn J. Anderson
Article
Radiology, Nuclear Medicine & Medical Imaging
Michael C. Bellavia, Ravi B. Patel, Carolyn J. Anderson
Summary: Immune checkpoint inhibitors (ICIs) have revolutionized cancer care, but many patients with poorly immunogenic tumors fail to benefit. External beam radiotherapy (EBRT) has been shown to synergize with ICI to prompt remarkable tumor regression and even eradication, but is not suitable for widely disseminated disease. Targeted radiopharmaceutical therapy (TRT) selectively delivers radiation to both the primary tumor and the metastatic sites, and has shown promising results, leading to regulatory approval of certain agents.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Feyisola P. Olatunji, Michael Pun, Jacob W. Herman, Oscar Romero, Mitchell Maniatopoulos, Joseph D. Latoche, Robert A. Parise, Jianxia Guo, Jan H. Beumer, Carolyn J. Anderson, Clifford E. Berkman
Summary: This study reports on the synthesis, pharmacokinetics, and efficacy of two small-molecule-drug conjugates targeting prostate-specific membrane antigen, showing potential for delivering chemotherapy drugs to prostate cancer tumors with minimal toxicity.
MOLECULAR CANCER THERAPEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
