Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 56, Pages 7495-7498Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc02826k
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- Universite de Rennes 1
- CNRS
- Rennes Metropole
- Region Bretagne
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The first catalytic enantioselective Prins cyclization is disclosed. The reaction is catalyzed by the combination of a chiral BINOL-derived bis-phosphoric acid and CuCl. The process consists of a tandem Prins/Friedel-Crafts cyclization that affords the hexahydro-1H-benzo[f]isochromenes products with three new contiguous stereogenic centers in high yields, and good enantio-and excellent diastereoselectivities.
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