Journal
CHEMICAL COMMUNICATIONS
Volume 50, Issue 12, Pages 1481-1484Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc48223e
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Funding
- National Natural Science Foundation of China [21227008, 21275086]
- National Basic Research Program of China [2010CB732404]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)
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The surface plasmon resonance (SPR) and quartz crystal microbalance (QCM) aptasensors combined with rolling circle amplification and bio-bar- coded AuNP enhancement have been applied to detect the human alpha-thrombin for the first time. The assay platform exhibited excellent selectivity and sensitivity with detection limit as low as 0.78 aM.
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