Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 12, Pages 1169-1171Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc38742e
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) [20310140, 23310153]
- Grants-in-Aid for Scientific Research [10J05423, 24102528, 23310153] Funding Source: KAKEN
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The anthraquinone-sialic acid hybrids designed effectively degraded not only non-drug-resistant neuraminidase but also drug-resistant neuraminidase, which is an important target of anti-influenza therapy. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions. Moreover, the hybrids efficiently inhibited neuraminidase activities upon photo-irradiation.
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