Selective trihydroxyazepane NagZ inhibitors increase sensitivity of Pseudomonas aeruginosa to β-lactams

The Development of Selective Inhibitors of NagZ: Increased Susceptibility of Gram-Negative Bacteria to β-Lactams

(2013) Keith A. Stubbs et al.   CHEMBIOCHEM

Fortifying the wall: synthesis, regulation and degradation of bacterial peptidoglycan

(2013) Solmaz Sobhanifar et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Active Site Plasticity within the Glycoside Hydrolase NagZ Underlies a Dynamic Mechanism of Substrate Distortion

(2012) John-Paul Bacik et al.   CHEMISTRY & BIOLOGY

Developing inhibitors of glycan processing enzymes as tools for enabling glycobiology

(2012) Tracey M Gloster et al.   Nature Chemical Biology

Access to l- and d-Iminosugar C-Glycosides from a d-gluco-Derived 6-Azidolactol Exploiting a Ring Isomerization/Alkylation Strategy

(2012) Martine Mondon et al.   ORGANIC LETTERS

Inhibitors for Bacterial Cell-Wall Recycling

(2012) Takao Yamaguchi et al.   ACS Medicinal Chemistry Letters

Binding of 3,4,5,6-Tetrahydroxyazepanes to the Acid-β-glucosidase Active Site: Implications for Pharmacological Chaperone Design for Gaucher Disease

(2011) Susan D. Orwig et al.   BIOCHEMISTRY

Development of GlcNAc-Inspired Iminocyclitiols as Potent and SelectiveN-Acetyl-β-Hexosaminidase Inhibitors

(2010) Ching-Wen Ho et al.   ACS Chemical Biology

NagZ Inactivation Prevents and Reverts  -Lactam Resistance, Driven by AmpD and PBP 4 Mutations, in Pseudomonas aeruginosa

(2010) L. Zamorano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Structural and Kinetic Analysis ofBacillus subtilis N-Acetylglucosaminidase Reveals a Unique Asp-His Dyad Mechanism

(2010) Silke Litzinger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing the Reaction Coordinate of an O-GlcNAc Hydrolase

(2010) Yuan He et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and synthesis of acetamido tri- and tetra-hydroxyazepanes: Potent and selective β-N-acetylhexosaminidase inhibitors

(2009) Hongqing Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular Basis for Inhibition of GH84 Glycoside Hydrolases by Substituted Azepanes: Conformational Flexibility Enables Probing of Substrate Distortion

(2009) Filipa Marcelo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Insight into a strategy for attenuating AmpC-mediated β-lactam resistance: Structural basis for selective inhibition of the glycoside hydrolase NagZ

(2009) Misty D. Balcewich et al.   PROTEIN SCIENCE

β-Lactam Resistance Response Triggered by Inactivation of a Nonessential Penicillin-Binding Protein

(2009) Bartolomé Moya et al.   PLoS Pathogens

The Carbohydrate-Active EnZymes database (CAZy): an expert resource for Glycogenomics

(2008) B. L. Cantarel et al.   NUCLEIC ACIDS RESEARCH