4.7 Article

Metallo-toeholds: controlling DNA strand displacement driven by Hg(II) ions

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 85, Pages 9953-9955

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc45373a

Keywords

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Funding

  1. National Natural Science Foundation of China [20934004, 91127046]
  2. National Basic Research Program of China (NBRPC) [2012CB821500, 2010CB934500]

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Toehold-mediated strand displacement is a powerful tool that permits programmable control over DNA hybridization. Here, we developed a mechanism for strand displacement driven by Hg2+ ions, in which the insertion of thymine-thymine mismatched base pairs on the toeholds provides additional control through variation of the concentration of Hg2+ ions.

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