4.7 Article

Copper catalyzed oxidative coupling of amines with formamides: a new approach for the synthesis of unsymmetrical urea derivatives

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 59, Pages 6686-6688

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc42381f

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Funding

  1. Council of Scientific and Industrial Research (CSIR)
  2. University Grants Commission (UGC)
  3. CSIR, India [CSC-0125]

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Direct access to unsymmetrical urea derivatives via copper catalysed C-H/N-H coupling of formamides with amines has been developed at room temperature. This protocol is also applied to the synthesis of chiral urea derivatives.

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