Article
Biochemistry & Molecular Biology
Chih-Hsiang Hu, Remi Veneziano
Summary: This study developed a responsive controlled release system using DNA nanotechnology tools and strand displacement circuit, allowing precise control over the release of biomolecules. The system was successfully incorporated within a gelatin hydrogel and demonstrated the ability to release multiple model cargos with temporal specificity.
Review
Pharmacology & Pharmacy
Lidya Abune, Yong Wang
Summary: Affinity hydrogels offer the potential to stably retain and sustainably release proteins through a binding reaction, different from traditional hydrogels. Future research may focus on developing intelligent affinity hydrogels to mimic human tissue properties and release single or multiple proteins on demand in response to environmental stimuli.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Carter J. Teal, Marian H. Hettiaratchi, Margaret T. Ho, Arturo Ortin-Martinez, Ahil N. Ganesh, Andrew J. Pickering, Alex W. Golinski, Benjamin J. Hackel, Valerie A. Wallace, Molly S. Shoichet
Summary: By using directed evolution, specific affibody binding partners have been engineered to independently control the release rates of therapeutic proteins. In vivo testing on mice demonstrated the sustained activity of the controlled release, leading to improved efficacy.
ADVANCED MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Morgan Chandler, Brian Minevich, Brandon Roark, Mathias Viard, M. Brittany Johnson, Mehedi H. Rizvi, Thomas A. Deaton, Seraphim Kozlov, Martin Panigaj, Joseph B. Tracy, Yaroslava G. Yingling, Oleg Gang, Kirill A. Afonin
Summary: This research demonstrates the controlled assembly of 3D QD structures in cells using nucleic acids as programmable crosslinkers. The morphologies and functions of these structures were evaluated through various methods and experimental results, showcasing the potential therapeutic applications of QD assemblies in cells.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Matthew Stephens
Summary: Nucleic acid aptamers, refined from random sequences, have the ability to bind to various targets and possess advantages over protein-based therapeutics. Despite these advantages and the approval of several nucleic acid-based therapeutics, conventional biologics still dominate the field. Recent research has identified potential aptamers that could reshape medicine as diagnostic tools and treatments.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Anna-Lena Leistner, David Georg Kistner, Christian Fengler, Zbigniew L. Pianowski
Summary: A study found that a cyclic dipeptide containing azobenzene can form composite supramolecular hydrogels with alginate, which can be reversibly converted to fluid by external UV light. The gels can also encapsulate and release fluorescent cargo.
Article
Biochemical Research Methods
Esau Medina, Eric J. Yik, Piet Herdewijn, John C. Chaput
Summary: XNA polymerases have great potential in synthetic biology, but little is known about their biochemical properties. This study compared various evolved polymerases and found that mutations for XNA synthesis increased substrate tolerance but could affect protein folding stability. Additionally, reverse transcriptase activity on different XNA substrates varied among polymerases. These findings can help in the development of new polymerase variants with improved activity and specificity.
ACS SYNTHETIC BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Carme Fabrega, Anna Avino, Ramon Eritja
Summary: The article discusses the advancements in the therapeutic and diagnostic applications of nucleic acids over the past decade, including studies on siRNA modifications, novel conjugate designs, and the use of nanostructures for drug delivery. These interdisciplinary research efforts have expanded the applications of nucleic acids in various fields.
Article
Chemistry, Multidisciplinary
Richard L. Redman, Isaac J. Krauss
Summary: Carbohydrate binding proteins are important targets in medicine and biology, and multivalency plays a key role in high-affinity interactions. A novel platform for designing multivalent carbohydrate cluster ligands by directed evolution using serum-stable 2'-fluoro modified RNA backbones has been developed. This method was validated by selecting oligomannose glycan clusters that bind to broadly neutralizing HIV antibody 2G12 with affinities ranging from 13 to 36 nM from a large sequence pool.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Multidisciplinary
Conor Lanphere, Patrick M. Arnott, Sioned Fon Jones, Katarina Korlova, Stefan Howorka
Summary: A synthetic molecular gate constructed using DNA nanotechnology can be opened in response to a specific protein, allowing controlled release of enclosed cytotoxic drugs in delivery vesicles to effectively kill eukaryotic cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Physical
Jorieke Weiden, Maartje M. C. Bastings
Summary: DNA nanostructures have emerged as a versatile platform for controlled drug delivery, offering unparalleled control over structural and functional parameters. Recent applications in therapeutic drug delivery show promising alternatives to conventional nanomaterials, but further research is needed to understand biodistribution, final fate, and controlled drug release aspects.
CURRENT OPINION IN COLLOID & INTERFACE SCIENCE
(2021)
Article
Chemistry, Multidisciplinary
Tuan Trinh, Ian Andrew Paul Thompson, Finley Clark, Jacob M. Remington, Michael Eisenstein, Jianing Li, Hyongsok Tom Soh
Summary: In this study, a design of intramolecular triplex photoswitch based on single-stranded DNA was reported, which enables rapid and reversible switching between folded and unfolded states through isomerization of internal azobenzene modifications. Molecular dynamics simulations revealed the contribution of individual azobenzenes to the stabilization or destabilization of the triplex depending on their photoisomerization state.
Review
Biotechnology & Applied Microbiology
Yanghui Xing, Buhui Zeng, Wang Yang
Summary: Light responsive hydrogels are an important drug delivery system that can accurately control drug release by incorporating photosensitive moieties into their structures. Advances in photosensitizers have enabled the use of different light sources, and hydrogels with photosensitizers have improved therapeutic effects. Existing light responsive drug delivery systems have been applied in chemotherapy, immunotherapy, photodynamic therapy, gene therapy, and other fields.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhichu Xiang, Jian Zhao, Deyu Yi, Zhenghan Di, Lele Li
Summary: The study introduces a protease-activatable aptamer system for molecular sensing and imaging in a tumor-specific manner. By utilizing a PNA-peptide-PNA triblock copolymer to lock the structure-switching activity of the aptamer, protease-mediated cleavage of the peptide substrate can reduce binding affinity and recover the biosensing function. This work demonstrates the potential of bridging the gap between functional DNA and peptides for precise biomedical applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Biophysics
Xiaoyu Xie, Ruifang Ke, Chen Cheng, Yi-Hui Wang, Zhen Song, Chang-Dong Zhang, Huai-Song Wang
Summary: The enrichment and detection of circulating free nucleic acids in biological samples have gained significant attention for disease diagnosis or prognostic evaluation. Nanoscale metal-organic frameworks (NMOFs) have been used for aptamer-based nucleic acid sensing, showing promising platforms for nucleic acid extraction and fluorescent sensing.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Biochemical Research Methods
Jing Zhou, Mark R. Battig, Yong Wang
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2010)
Article
Biochemistry & Molecular Biology
Erin Richards, Shihui Li, Niancao Chen, Mark R. Battig, Yong Wang
Article
Engineering, Biomedical
Boonchoy Soontornworajit, Jing Zhou, Matthew P. Snipes, Mark R. Battig, Yong Wang
Article
Engineering, Biomedical
Mark R. Battig, Yike Huang, Niancao Chen, Yong Wang
Article
Chemistry, Multidisciplinary
Zhaoyang Zhang, Niancao Chen, Shihui Li, Mark R. Battig, Yong Wang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Article
Chemistry, Multidisciplinary
Mark R. Battig, Boonchoy Soontornworajit, Yong Wang
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Article
Chemistry, Multidisciplinary
Niancao Chen, Shihui Li, Mark R. Battig, Yong Wang
Article
Medicine, Research & Experimental
Sarah E. Sheppard, Michael E. March, Christoph Seiler, Leticia S. Matsuoka, Sophia E. Kim, Charlly Kao, Adam I. Rubin, Mark R. Battig, Nahla Khalek, Erica Schindewolf, Nora O'Connor, Erin Pinto, Jessica R. C. Priestley, Victoria R. Sanders, Rojeen Niazi, Arupa Ganguly, Cuiping Hou, Diana Slater, Ilona J. Frieden, Thy Huynh, Joseph T. Shieh, Ian D. Krantz, Jessenia C. Guerrero, Lea F. Surrey, David M. Biko, Pablo Laje, Leslie Castelo-Soccio, Taizo A. Nakano, Kristen Snyder, Christopher L. Smith, Dong Li, Yoav Dori, Hakon Hakonarson
Summary: Central conducting lymphatic anomaly (CCLA), a debilitating and potentially life-threatening disease, can be caused by congenital maldevelopment of the lymphatics. Through studying individuals with CCLA and microcystic lymphatic malformation, researchers identified pathogenic KRAS variants, which activate the RAS/MAPK pathway. Using cell and animal models, they found that MEK inhibition could effectively reduce lymphatic dysplasia and edema. These findings suggest that MEK inhibition should be further investigated as a targeted therapy for CCLA caused by activating KRAS pathogenic variants.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
