Article
Chemistry, Analytical
Liang-Yong Yang, Xiong-Wei Xu, Yan Lin, Chen-Liu Ye, Wei-Qiang Liu, Zhou-Jie Liu, Guang-Xian Zhong, Yan-Fang Xu, Xin-Hua Lin, Jin-Yuan Chen
Summary: This study developed a nucleic acid template-dominated click chemistry-mediated ligation chain reaction (cc-eLCR) for efficient and specific nucleic acid amplification. The cc-eLCR method, which utilized nM-level DNA probes and an electrochemical platform, successfully detected low-level nucleic acid targets with single-base resolution. Moreover, the cc-eLCR assay was also applied to detect target molecules in cell extracts, showing its potential in medical diagnosis and biomedical research.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Yibiao Liu, Zhen Huang, Qing Xu, Lingyan Zhang, Qiong Liu, Tailin Xu
Summary: Alzheimer's disease, as a prevalent type of dementia, is becoming one of the most expensive and lethal diseases of this century. Although there are no efficient therapies, early diagnosis and intervention are crucial for clinical works. Researchers have developed a portable electrochemical micro-workstation platform that can simultaneously detect multiple Alzheimer's disease biomarkers in serum, providing a promising strategy for early diagnosis and personal healthcare.
Article
Chemistry, Analytical
Yi-Kuang Yen, Guang-Wei Huang, Ragurethinam Shanmugam
Summary: In this study, a graphene electrochemical sensor based on laser graphene polymer material was developed to detect cancer proteins. The sensor produced stable power and had the advantages of consistency, conductivity, and flexibility. By modifying laser-scribed graphene electrodes (LSG), the sensor showed good sensitivity and specificity for cancer detection. The sensor was able to detect specific cancer proteins in both phosphate buffer saline (PBS) and serum environments.
Article
Chemistry, Analytical
Wancun Zhang, Kangbo Liu, Pin Zhang, Weyland Cheng, Yaodong Zhang, Linfei Li, Zhidan Yu, Mengmeng Chen, Lin Chen, Lifeng Li, Xianwei Zhang
Summary: The developed all-in-one approach enables rapid, facile, specific, and sensitive quantification of SNPs. By combining LDR and MB probes, this method demonstrates high specificity and detection sensitivity, suitable for in vitro and clinical samples.
Article
Biophysics
Hanjun Chen, Ying Liu, Shaoqiong Feng, Yu Cao, Tingting Wu, Zhihong Liu
Summary: A cotton thread-based multi-channel photothermal biosensor was developed for simultaneous detection of multiple breast cancer-related miRNAs. The biosensor exhibited excellent specificity and sensitivity, with detection limits of 37 pM for miRNA-10b, 38 pM for miRNA-27a, and 38 pM for miRNA-let-7a. The biosensor also showed great potential in clinical diagnosis.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Weicheng Shi, Yao Gong, Decai Zhang, Tiantian Yang, Ming Yi, Jingyi Tan, Shijia Ding, Wei Cheng
Summary: In this study, a strategy based on rolling circle amplification and CRISPR/Cas14a was developed for highly specific detection of BRAF V600E mutation in fine-needle biopsy samples. The method showed outstanding specificity and discrimination ability, and was successfully applied in clinical samples. This approach provides a novel method for the diagnosis and treatment of cancer.
ANALYTICAL METHODS
(2022)
Article
Chemistry, Analytical
Zhuping Shen, Shengnan Ni, Wenchao Yang, Wanping Sun, Guangfu Yang, Guozhen Liu
Summary: This study presents a molecular beacon aptamer-functionalized electrochemical sensing platform for simultaneous and real-time monitoring of three cytokines. The platform successfully achieved simultaneous quantification of VEGF, IFN-γ, and TNF-α, with promising results in human serum and artificial sweat. It provides a reliable electrochemical sensing platform for simultaneous monitoring of multiple analytes in real time.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Chemistry, Analytical
Na Wang, Jing Wang, Xiaoqing Zhao, Hou Chen, Hui Xu, Liangjiu Bai, Wenxiang Wang, Huawei Yang, Donglei Wei, Baiqing Yuan
Summary: A novel sandwich-type electrochemical immuno sensor has been developed for simultaneous determination of three tumor markers utilizing graphene oxide and PSMA. The sensor demonstrated a linear response and high sensitivity for the detection of prostate specific antigen, human α-fetoprotein, and carbohydrate antigen 125, offering a simple and sensitive method for early cancer identification.
Article
Biochemistry & Molecular Biology
Sneha Gopalan, Yuqing Wang, Nicholas W. Harper, Manuel Garber, Thomas G. Fazzio
Summary: Multi-CUT&Tag allows simultaneous mapping of multiple proteins in the same cells using antibody-specific barcodes, revealing co-localization sites of histone marks and RNA Polymerase II, active and repressed genes, and candidate cis-regulatory elements. This technology aids in identifying distinct cell types and characterizing their chromatin architecture.
Article
Chemistry, Applied
Maosai Zhang, Wenchuan Guo
Summary: A sensitive and simple analytical method combining Fe3O4@SiO2-based extraction with direct electrochemical detection was successfully applied to individually and simultaneously analyze heavy metal ions (including Cd2+, Pb2+, Cu2+, and Hg2+). The method exhibited good sensitivity with detection limits in the nanomolar range, and achieved recoveries ranging from 96.0% to 104.3% in milk samples. This approach shows great potential for quantitative analysis of multiple heavy metal ions in milk.
Review
Electrochemistry
Tugba Ozer, Charles S. Henry
Summary: This review explores the use of electrochemical sensor arrays in various chemical/biological sensing applications, highlighting the importance of multi-electrode arrays for detecting multiple targets in a single assay. Various electrochemical techniques and electrode modifications have been utilized to enhance performance. The review specifically focuses on recent developments in sensor arrays based on microfluidic and paper-based devices, as well as their integration with portable potentiostats and wireless data acquisition technology for simultaneous analysis of multiple targets.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2021)
Article
Multidisciplinary Sciences
Gaolian Xu, Hao Yang, Jiani Qiu, Julien Reboud, Linqing Zhen, Wei Ren, Hong Xu, Jonathan M. M. Cooper, Hongchen Gu
Summary: The authors propose a method called STEM-PCR for rapid and facile detection of specific nucleic acid modifications. This method utilizes a simple and widely accessible PCR-based workflow, and exhibits sensitivity 20 times greater than current gold-standard techniques by using a bisulfite-free process. They successfully demonstrate the clinical applicability of this method by detecting methylation of SEPTIN9 and SFRP2 genes, which are key biomarkers in tumor prognosis and diagnosis.
NATURE COMMUNICATIONS
(2023)
Article
Biophysics
Xuejiao Liu, Yuanliang Li, Li He, Yongjun Feng, Huangying Tan, Xu Chen, Wensheng Yang
Summary: An ultrasensitive and antifouling label-free electrochemical immunosensor was developed for simultaneous analysis of NETs biomarkers CgA and CgB. The sensor platform exhibited excellent antifouling ability and could efficiently work in complex biological systems. It accurately detected CgA and CgB levels in clinical serum.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Chemistry, Physical
Rikitha S. Fernandes, Nilanjan Dey
Summary: A colorimetric probe based on anthraimidazoledione has been developed for detecting heavy metal pollutants in acetonitrile medium. Different metal ions induce redshifts and fluorescence quenching, and the colorimetric responses depend on various factors. In mixed aqueous environment, only Co2+ ion causes colorimetric change.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Multidisciplinary Sciences
Tina Roostaei, Hans-Ulrich Klein, Yiyi Ma, Daniel Felsky, Pia Kivisakk, Sarah M. Connor, Alexandra Kroshilina, Christina Yung, Belinda J. Kaskow, Xiaorong Shao, Brooke Rhead, Jose M. Ordovas, Devin M. Absher, Donna K. Arnett, Jia Liu, Nikolaos Patsopoulos, Lisa F. Barcellos, Howard L. Weiner, Philip L. De Jager
Summary: By establishing a genome-wide map of DNA methylation quantitative trait loci in CD4(+) T-cells from multiple sclerosis patients, this study identified key loci where the same haplotype influences both multiple sclerosis susceptibility and local DNA methylation. Additionally, the study revealed distant methylation effects of multiple sclerosis susceptibility loci, shedding light on new gene targets for investigating predisposition to the disease. Integration of functional data with GWAS loci helped interpret genetic variants associated with multiple sclerosis.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)