4.7 Article

Auto-tandem catalysis: synthesis of 4H-pyrido[1,2-a]pyrimidin-4-ones via copper-catalyzed aza-Michael addition-aerobic dehydrogenation-intramolecular amidation

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 17, Pages 1729-1731

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc38131e

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Funding

  1. National Natural Science Foundation of China [21032001, 21272085]

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A copper-catalyzed domino synthesis of 4H-pyrido[1,2-a]pyrimidin4-ones has been developed from 1,4-enediones and 2-aminoheterocycles with air as the oxidant.

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