Article
Biochemistry & Molecular Biology
Qinxiang Zheng, Feng Ding, Xiaojuan Hu, Jiayao Feng, Jianliang Shen, Xiaojun He
Summary: The study presents the successful development and application of a novel group IIIA ions fluorescent probe, NBD-hnap, which exhibits high sensitivity and selectivity, operating through an ESIPT-based fluorescent sensing mechanism, suitable for detecting Al(III), Ga(III), and In(III) in aqueous solutions.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Ruowei Tian, Taiyu Guo, Bin Yang, Wangbo Qu, Zhirong Geng, Zhilin Wang
Summary: Copper is essential for vital enzymes but toxic in excess. Recent research shows copper-dependent programmed death, called cuproptosis, which has potential in overcoming tumor resistance to traditional therapies. Lysosomes, central to cellular copper regulation, can be accurately targeted and monitored using the novel NIR fluorescent probe, CyCu. The fluctuation of lysosomal copper pools during cuproptosis indicates its potential as a new target for HCC treatment.
Article
Chemistry, Applied
Xiuxiu Dai, Zengqiang Liang, Yang Li, Jian Tao, Lingbo Qu, Linping Zhao, Ran Yang
Summary: A self-calibrating fluorescence sensing system was developed for the rapid detection of copper (II) ions in wine. Only yellow fluorescence is selectively quenched by the copper (II) ions, resulting in a change of fluorescence image from yellow to blue. The system showed good linearity with a detection limit of 46.5 nmol/L.
Article
Chemistry, Applied
Yin Chen, Zhiqing Long, Chengcheng Wang, Jingjing Zhu, Shasha Wang, Yan Liu, Peng Wei, Tao Yi
Summary: In this study, a near-infrared fluorescent probe was designed and synthesized for the high sensitivity and selective detection of Cu2+ in lysosomes, with the ability to respond to changes in Cu2+. This has significant implications for investigating the physiological functions of Cu2+ and related diseases.
Article
Chemistry, Multidisciplinary
Wen-Jing Shi, Jinrong Yang, Yong-Feng Wei, Xiao-Tong Li, Xu-Hui Yan, Yuxuan Wang, Huaxiang Leng, Liyao Zheng, Jin-wu Yan
Summary: Two novel meso-CF3 BODIPY-based fluorescent rotors were rationally prepared and found to sensitively respond to viscosity in living cells with a fluorescence turn-on effect, which can be attributed to the special restricted rotation of meso-CF3 group in viscous environments. Interestingly, a monostyryl probe with one cationic group exhibited good mitochondrial localization and aggregation-induced emission (AIE) property.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Applied
Pengli Guan, Shuman Shi, Tingshuo Zhang, Jie Chai, Binsheng Yang, Bin Liu
Summary: This article reports a double site fluorescent probe T that can distinguish cancer cells from normal cells using different fluorescence colors. This finding is valuable for tumor resection and other related research.
Article
Biochemistry & Molecular Biology
Qiuchen Liu, Chang Liu, Song He, Xianshun Zeng, Jian Zhang, Jin Gong
Summary: In this study, a lysosome-targeted near-infrared fluorescent probe, BCy-Cys, was synthesized by modifying the thioxanthene-benzothiozolium fluorophore for the detection of cysteine (Cys) from homocysteine (Hcy) and glutathione (GSH). BCy-Cys exhibited high selectivity and sensitivity for Cys detection over Hcy/GSH, with a low limit of detection at 0.31 μM. HRMS analysis confirmed the enhancement of intramolecular charge transfer (ICT) significantly increased the fluorescence intensity at 795 nm. Importantly, BCy-Cys could visualize both exogenous and endogenous lysosomal Cys, showing its potential application in complex organismal systems.
Article
Chemistry, Applied
Yongqiang Shi, Wenting Li, Xuping Feng, Lei Lin, Pengcheng Nie, Jiyong Shi, Xiaobo Zou, Yong He
Summary: A novel aptamer-modified Copper @ Gold nanoclusters based ratiometric fluorescent probe was developed for mercury ions determination in Porphyra, with a detection limit of 4.92 nM. Additionally, a homemade device for colorimetric determination of Hg2+ was designed, showing good portability and usefulness. The study suggests the considerable potential of these methods for evaluating Hg2+ levels in aquatic products.
Article
Chemistry, Physical
Devaraj Sabarinathan, Arumugam Selva Sharma, Akwasi Akomeah Agyekum, Marimuthu Murugavelu, Poorna Chandrika Sabapathy, Shujat Ali, Hamada Hassan, Huanhuan Li, Quansheng Chen
Summary: This work presents a single-step reduction method for the synthesis of highly stable water-soluble copper nanoclusters (CuNCs) using Thunnus albacares fish protein (FP) as a capping and reducing agent at ambient conditions. The physicochemical properties of the prepared CuNCs were characterized, and the FP-CuNCs exhibited high photo stability and excellent fluorescent properties under different ionic strength and pH. The fluorescence of FP-CuNCs was utilized for the detection of Fe3+ ions in aqueous conditions with a low limit of detection. The practical applicability of the detection probe was demonstrated in environmental sample analysis.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Stephen M. Butler, Maria Hountondji, Stuart N. Berry, Jian Tan, Laurence Macia, Katrina A. Jolliffe
Summary: A macrocyclic fluorescent probe has been developed for the detection of citrate, which exhibits a turn-on in fluorescence upon binding through hydrogen-bonding interactions in aqueous solutions. The probe shows minimal interference from other biologically relevant dicarboxylate species. The utility of this probe has been demonstrated through staining of murine splenocytes and flow cytometry analysis, enabling the identification of different basal levels of citrate in immune cell subsets.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Analytical
Shaoqing Li, Gufeng Li, Hongyu Shi, Min Yang, Wei Tan, Hongbin Wang, Wenrong Yang
Summary: Blue fluorescent tryptophan-coated silver nanoclusters (Trp-Ag NCs) with excellent photoluminescence properties were prepared for Cu2+ detection and bioimaging.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Huihui Mei, Xin Gu, Minghui Wang, Jiajia Chen, Xindi Yang, Xuejun Liu, Kuoxi Xu
Summary: A new pH fluorescent probe based on reversible structural changes was developed, providing three reversible pH response modes within a wide pH range. It is suitable for monitoring pH and fluorescence imaging in living cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Shijun Chen, Xiaodong Ma, Lin Wang, Yuanyuan Wu, Yaping Wang, Wenkang Fan, Shicong Hou
Summary: In this study, a feasible design strategy using intramolecular photoinduced electron transfer (PET) process was proposed to obtain a pH-sensitive beta-gal activable fluorescent probe (MLC). The probe selectively reacted with beta-gal and produced strong fluorescence at low pH. The probe demonstrated high selectivity, lower cytotoxicity, lysosomal localization, and fast response time, making it a potentially powerful tool in cancer prevention and treatment.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Xiaodan Zeng, Song Gao, Cheng Jiang, Qingxia Duan, Mingshuo Ma, Zhigang Liu, Jie Chen
Summary: A new rhodol-derived fluorescent probe 1 with high selectivity and sensitivity for Cu2+ detection was designed and synthesized. It can detect Cu2+ concentration in water samples and cell imaging experiments, showing potential for application in real environmental detection.
Article
Chemistry, Organic
Stephen M. Butler, Maria Hountondji, Stuart N. Berry, Jian Tan, Laurence Macia, Katrina A. Jolliffe
Summary: We introduce a macrocyclic fluorescent probe for the detection of citrate, which exhibits a turn-on fluorescence response upon binding and is minimally affected by other biologically relevant dicarboxylate species. The utility of this probe has been demonstrated through staining murine splenocytes and identifying different basal levels of citrate in immune cell subsets using flow cytometry analysis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Chunxia Chen, Shihai Yan, Shuang Qiu, Zhirong Geng, Zhilin Wang
Summary: The study demonstrated that FG4592 promotes the proliferation and migration of BMSCs, accelerating fracture healing. Additionally, HIF-1 alpha plays a crucial role in this process.
Article
Pharmacology & Pharmacy
Liu Shun, Wang Yi-xuan, Wang Hai-dan, Geng Zhi-rong, Yan Shi-hai
Summary: This study established a method to detect seven effective components in SKTM simultaneously using UHPLC-MS/MS, which was validated to have good repeatability and accuracy. This method may provide a new reliable approach for quality control of SKTM.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Chemistry, Analytical
Taiyu Guo, Xinyue Chen, Wangbo Qu, Bin Yang, Ruowei Tian, Zhirong Geng, Zhilin Wang
Summary: A novel fluorescent probe, CySI, was developed to simultaneously distinguish cysteine and homocysteine with excellent selectivity and fast response. This probe could visualize exogenous Cys and Hcy in cells and monitor endogenous Cys fluctuations independently in mitochondria through the red emission channel.
ANALYTICAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Chunxia Chen, Shihai Yan, Zhirong Geng, Zhilin Wang
Summary: The HIF-1 alpha PHD inhibitor IOX2 improves the proliferation and migration of BMSCs by upregulating intracellular Ca2+ and decreasing ROS, thus promoting fracture healing.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Plant Sciences
Shihai Yan, Jiayin Chang, Xuehui Hao, Jiang Liu, Xiying Tan, Zhirong Geng, Zhilin Wang
Summary: The study found that berberine can alleviate the occurrence of colitis-associated colorectal tumors by altering the composition of intestinal flora. Berberine increases beneficial bacteria and levels of short-chain fatty acids, reducing inflammation and the risk of cancer.
Article
Multidisciplinary Sciences
Shi-Hai Yan, Li-Mu Hu, Xue-Hui Hao, Jiang Liu, Xi-Ying Tan, Zhi-Rong Geng, Jing Ma, Zhi-Lin Wang
Summary: This study revealed the direct binding target protein of berberine in colorectal cancer cells, which is pyruvate kinase isozyme type M2 (PKM2). Berberine inhibits the progression of colorectal cancer through hydrophobic interaction and pi-pi interaction, and it also inhibits the reprogramming of glucose metabolism.
Article
Chemistry, Applied
Taiyu Guo, Ruowei Tian, Wangbo Qu, Bin Yang, Zhirong Geng, Zhilin Wang
Summary: A mitochondria-targeted turn-on fluorescent sensor, CySH, with near-infrared absorption and emission wavelengths, was developed for the selective determination of copper, showing high selectivity and excellent anti-interference ability.
Article
Biochemistry & Molecular Biology
Tianxiang Li, Zhirong Geng, Ju Zhang, Lu Xu, Xiaoli Zhu
Summary: This study demonstrates the protective effects of pentapeptide bursopentin (BP5) against endotoxemia-induced acute lung injury. BP5 effectively alleviates lung injury by reducing oxidative stress and excessive inflammatory response through activation of the Nrf2 pathway. This mechanism involves the regulation of Keap1-Nrf2 interaction and Akt/GSK3 beta/Fyn pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Spectroscopy
Wangbo Qu, Taiyu Guo, Bin Yang, Ruowei Tian, Shuang Qiu, Xinyue Chen, Zhirong Geng, Zhilin Wang
Summary: DFSN is a fluorescent probe with AIE and ESIPT, which can efficiently track hypochlorous acid in vivo. The probe has good selectivity and sensitivity, and can detect hypochlorous acid with the naked eye.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Wangbo Qu, Bin Yang, Taiyu Guo, Ruowei Tian, Shuang Qiu, Xinyue Chen, Zhirong Geng, Zhilin Wang
Summary: In this study, a dual-response mitochondria-targeted fluorescent probe HBTN was developed for the quantitative detection of viscosity and HOCl. The probe showed promising results in both in vitro and in vivo experiments, providing a practical tool for monitoring viscosity and HOCl.
Editorial Material
Pharmacology & Pharmacy
Qiuwang Zhang, Shihai Yan, Dongdong Sun, Zhirong Geng, Peixiang Zhang
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Analytical
Bin Yang, Ruowei Tian, Taiyu Guo, Wangbo Qu, Jiao Lu, Yong Li, Zhou Wu, Shihai Yan, Zhirong Geng, Zhilin Wang
Summary: This study reports the latest progress in using tetraphenylethylene (TPE) fluorophores as a tool for detecting intracellular adenosine triphosphate (ATP). Six different ATP probes were synthesized, and probes with dual positive charge sites showed better selectivity and sensitivity. Among them, P2, with a D-π-A structure, 1,4-bis(bromomethyl)benzene linker, and dual positive charge recognition sites, exhibited higher sensitivity and selectivity in ATP detection. This research has important application value in monitoring the fluctuations of mitochondrial ATP levels.
ANALYTICAL CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Hong Huang, Junyao Xu, Siqi Zhang, Jing Zhao, Shun Liu, Lei Tian, Haidan Wang, Zhirong Geng, Shihai Yan
Summary: This study used network pharmacology combined with UHPLC-MS/MS, molecular docking, and in vivo validation to investigate the active components and therapeutic mechanisms of SKTMG in the treatment of heart failure. The results identified 192 active compounds and 307 potential consensus targets for SKTMG, and discovered 10 core target genes related to the MAPK signal pathway. Additionally, SKTMG components were found to bind to specific targets and inhibit phosphorylation, leading to improved CHF in rats.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Hai-Li Yang, Li-Fei Bai, Zhi-Rong Geng, Hao Chen, Le-Tian Xu, Yang-Cun Xie, Dong-Jin Wang, Hong-Wei Gu, Xiao-Ming Wang
Summary: As an excellent fluorescent nanomaterial, carbon quantum dots (CQDs) possess various properties that make them suitable for biomedical applications. This review provides an overview of the synthesis methods, optical properties, and biomedical applications of CQDs, including detection, imaging, and drug delivery. The review also discusses the challenges and future prospects of CQDs in the biomedical sector.
MATERIALS TODAY ADVANCES
(2023)
Article
Chemistry, Applied
Bin Yang, Wangbo Qu, Taiyu Guo, Ruowei Tian, Shuang Qiu, Xinyue Chen, Zhirong Geng, Zhilin Wang
Summary: A tetraphenylethylene fluorophore based on D-pi-A structure was used to design and synthesize the TPE-PyFP probe for selective detection of ATP. TPE-Py-FP showed a turn-on response after adding ATP and had a wide linear range and low limit of detection. The detection mechanism was mainly the electrostatic interaction between the positively charged sites of TPE-Py-FP and the negatively charged triphosphate structure of ATP.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
