4.7 Article

A real-time colorimetric assay for label-free detection of microRNAs down to sub-femtomolar levels

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 43, Pages 4959-4961

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc41565a

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Funding

  1. A*STAR-ANR Program

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A real-time colorimetric assay utilizing gold nanoparticle networks and a duplex-specific nuclease (DSN) for label-free detection of microRNAs is proposed. Excellent sensitivity and selectivity were accomplished through the engagement of the DSN and a cumulative signal amplification process.

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