4.7 Article

CuBr for KA2 reaction: en route to propargylic amines bearing a quaternary carbon center

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 79, Pages 8976-8978

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc45301d

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Funding

  1. National Basic Research Program of China [2011CB808700]
  2. National Natural Science Foundation of China [21232006]

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A highly efficient CuBr-catalyzed coupling of ketones, amines and alkynes (KA(2)) forming propargylic amines bearing a quaternary carbon center with the broadest scope so far has been developed.

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