Journal
CHEMICAL COMMUNICATIONS
Volume 49, Issue 58, Pages 6558-6560Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc42854k
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Funding
- Welch Foundation [AX-1788]
- Max and Minnie Tomerlin Voelcker Fund
- San Antonio Life Sciences Institute (SALSI)
- University of Texas at San Antonio
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A novel stereospecific three-component reaction of aziridines and azetidines with arynes and acetonitrile has been developed. The reaction affords N-aryl gamma-aminobutyronitriles and delta-aminovaleronitriles that can be used as precursors and congeners of a number of bioactive compounds, such as pregabalin and lergotrile.
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