4.7 Article

Folding single-stranded DNA to form the smallest 3D DNA triangular prism

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 28, Pages 2906-2908

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c3cc39266j

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Funding

  1. University Grant Council of the Hong Kong government [RGC HKUST 603210]
  2. Hong Kong University of Science and Technology [RPC10SC12]
  3. China 985

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The smallest DNA 3D object, a triangular prism with only one turn on each edge, was constructed from a single-stranded DNA. We confirmed its structure using scanning tunneling microscopy. This work proves that single-stranded DNA can escape from kinetic traps to form stable topology.

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