4.7 Article

Small neutral molecular carriers for selective carboxylate transport

Journal

CHEMICAL COMMUNICATIONS
Volume 49, Issue 3, Pages 246-248

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc37468d

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Funding

  1. EPSRC
  2. EPSRC [EP/J009687/1] Funding Source: UKRI
  3. Engineering and Physical Sciences Research Council [EP/J009687/1] Funding Source: researchfish

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A series of neutral thiourea receptors were found to mediate the antiport of chloride with a range of biologically relevant carboxylate anions across phospholipid bilayers. Simple structural modification of the carriers resulted in a change in the lactate/pyruvate transport selectivity.

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