4.7 Article

Asymmetric [3+2] annulation of allenes with maleimides catalyzed by dipeptide-derived phosphines: facile creation of functionalized bicyclic cyclopentenes containing two tertiary stereogenic centers

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 7, Pages 970-972

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc16904e

Keywords

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Funding

  1. Shanghai Municipal Committee of Science and Technology [08dj1400100-2]
  2. National Basic Research Program of China (973) [2010CB833302]
  3. Fundamental Research Funds for the Central Universities
  4. National Natural Science Foundation of China [21072206, 20872162, 20672127, 20732008, 20821002, 20702013]

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D-Threonine-L-tert-leucine-derived bifunctional phosphine, Cat. 11, catalyzed highly enantioselective [3+2] annulation of maleimides with allenes has been disclosed, allowing the synthesis of optically active functionalized bicyclic cyclopentenes containing two tertiary stereogenic centers in good to high yields along with good to high enantioselectivities.

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