4.7 Article

Highly enantioselective organocatalytic Strecker reaction of cyclic N-acyl trifluoromethylketimines: synthesis of anti-HIV drug DPC 083

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 94, Pages 11552-11554

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc36307k

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Funding

  1. NSFC [20972110, 20902067, 21002068]

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A highly efficient, organocatalytic, enantioselective Strecker reaction of cyclic N-acyl ketimines was developed for the preparation of enantioenriched cyclic alpha-amino nitriles with a quaternary carbon stereocentre and anti-HIV drug DPC 083.

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