Review
Chemistry, Analytical
Jiamu Cao, Rongji Zhang, Liang Chen, Dongbo Wang, Weiqi Wang, Endong Tan, Xianghe Meng, Huaxin Xiu, Lin Wang, Xinglian Yang, Zhoumin Yang, Qijun Yang, Liancheng Zhao
Summary: Responsive metal-based luminescence probes, with advantages of large Stokes shifts, long lifetimes, high photostabilities, and easy ligand addition, are considered better alternatives to organic ones. This paper reviews critical strategies of achieving response by different stimulus sources and presents the current challenges and future opportunities of responsive metal-based luminescence probes.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Andrew J. Carrod, Francesco Graglia, Louise Male, Cecile Le Duff, Peter Simpson, Mohamed Elsherif, Zubair Ahmed, Haider Butt, Guang-Xi Xu, Kenneth Kam-Wing Lo, Paolo Bertoncello, Zoe Pikramenou
Summary: Dual detection systems are beneficial for rapid and accurate data collection in sensing systems and in vitro testing. The newly introduced Ir-III complex with a boronic acid receptor site attached to a 2-phenylpyridine ligand serves as an ideal probe for sensitive detection of monosaccharide binding, showing potential for integration into devices.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Multidisciplinary Sciences
Brian E. Fratto, Emma L. Culver, Gabriel Davis, Robert Deans, John B. Goods, Sean Hwang, Nicole K. Keller, John A. Lawrence, Alexander R. Petty, Timothy M. Swager, Joseph J. Walish, Zhengguo Zhu, Jason R. Cox
Summary: This paper reports on a method that enables a smartphone to perform laboratory quality time-resolved analysis of luminescent samples. By making small modifications to the smartphone and utilizing existing image capture applications and analysis software, this approach demonstrates the analytical potential of smartphones in tasks such as authentication, encryption, packaging, compounds, and physical phenomena. This method highlights the power of repurposing existing technologies to expand the reach and inclusivity of scientific exploration, creating new avenues for data collection and analysis.
Article
Optics
Maryam Baker, Euan McLeod
Summary: Fluorescence and photoluminescence can be used for high contrast imaging through the use of specific probes, but bulky microscopes require mechanical scanning and stitching for high space-bandwidth product images. Lensfree imaging can achieve a high space-bandwidth product through computational reconstruction from diffraction patterns. In this study, a time-gated lensfree photoluminescent imaging system with high resolution was developed using europium chelate fluorophores and temporal filtering.
Article
Chemistry, Analytical
Yudong Zhou, Song Lu, Jiahuan Zhi, Ruihong Jiang, Jiahao Chen, Hanbing Zhong, Huifang Shi, Xing Ma, Zhongfu An
Summary: This study demonstrates the preparation of ultralong organic phosphorescent nanoparticles (PDBCz@PVP) with excellent phosphorescence properties, which show promise for biological imaging applications.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Peisen Zhang, Jianfeng Zeng, Yingying Li, Chen Yang, Junli Meng, Yi Hou, Mingyuan Gao
Summary: The study introduces an Fe3O4 nanoparticle-based MRI probe that can quantitatively map the heterogeneous distribution of the tumor-specific biomarker GSH in vivo.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Optics
Qisheng Deng, Yulei Liu, Zece Zhu, Xuewen Shu
Summary: In this study, we demonstrate the use of a smartphone for the detection of time-gated luminescence spectra. By using a mechanical chopper and an optical switch, we achieved synchronization and control of the excitation source. The proposed approach successfully detected the time-gated luminescence spectra of Eu(TTA)3 powder and Eu-tetracycline complex solutions with a high temporal resolution.
Article
Polymer Science
Soshi Wakako, Yumiko Hori, Tomokazu Kinoshita, Takao Saiki, Xinyi Qi, Koki Hasegawa, Yoshitane Imai, Tadashi Mori, Keiichi Nakagawa, Gaku Fukuhara
Summary: In this study, a series of pyrene-labeled alpha- and epsilon-poly-l-lysine conjugates were synthesized and showed promising performance in sensing, imaging, and drug delivery. The materials demonstrated diverse ratiometric responses to hydrostatic pressure and offered valuable insights into the development of smart hydrostatic-pressure-responsive polymer materials.
Article
Chemistry, Analytical
Cheng-Yu Li, Jun-Xian Liu, Liu Yuheng, Jia-Ling Gao, Ya-Ling Chen, Jing-Wei He, Meng-Kun Xin, Da Liu, Bei Zheng, Xiaoming Sun
Summary: The recently developed DNA motor-based fluorescent biosensors offer a promising choice for bioimaging due to their design flexibility and signal amplification capacity. However, the uncontrollable initiation and the need for exogenous driving forces are major drawbacks. To overcome these obstacles, this study proposes two rewarding solutions involving light-controlled target recognition and self-driven walking pattern. The results demonstrate commendable sensitivity and specificity of the sensing approach, making it a powerful imaging platform with potential diagnostic ability for cancer care.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Deshu Kong, Bo Song, Jingli Yuan
Summary: The development of bioanalytical methods for selective and accurate detection of H2S is crucial for understanding its functions in biological systems. Researchers have developed a Golgi-targetable luminescent probe that can accurately determine H2S in aqueous solution and living cells using the RM-TGL technique.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Vasilii S. Kolmogorov, Alexander S. Erofeev, Emily Woodcock, Yuri M. Efremov, Aleksei P. Iakovlev, Nikita A. Savin, Anna V. Alova, Svetlana V. Lavrushkina, Igor I. Kireev, Alexandra O. Prelovskaya, Elena V. Sviderskaya, Denis Scaini, Natalia L. Klyachko, Peter S. Timashev, Yasufumi Takahashi, Sergey V. Salikhov, Yuri N. Parkhomenko, Alexander G. Majouga, Christopher R. W. Edwards, Pavel Novak, Yuri E. Korchev, Petr V. Gorelkin
Summary: A high-resolution estimation method for mechanical properties and the possibility of qualitative and quantitative analysis of living cells have been demonstrated in this study. Forces applied using a nanopipette are much smaller than those using atomic force microscopy, with no detectable effect on live cells.
Article
Chemistry, Analytical
Hirohisa Iwaki, Mako Kamiya, Minoru Kawatani, Ryosuke Kojima, Tatsuya Yamasoba, Yasuteru Urano
Summary: This study presents two activatable fluorescence probes for detecting basic carboxypeptidase activity in living cells, which can be used for visualizing cancer tissues. 5ArgAF-FDA showed a stronger intracellular fluorescence increase compared to 5LysAF-FDA, and can differentiate cell lines with varying levels of basic carboxypeptidase activity.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Yiliang Chen, Wei Yan, Duojing Guo, Yu Li, Ji Li, Hao Liu, Lirong Wei, Na Yu, Biao Wang, Ying Zheng, Maofeng Jing, Jing Zhao, Yonghao Ye
Summary: A highly efficient fluorescent probe was developed for selective and quantitative detection of ethylene in living biological systems. The probe showed great potential for elucidating the spatiotemporal regulation of ethylene biosynthesis and signal transduction in different cells and plants.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Engineering, Chemical
Dharshana Nalatamby, Florence Gibouin, Javier Ordonez-Hernandez, Julien Renaudeau, Geirald Clisson, Norberto Farfan, Pierre Lidon, Yaocihuatl Medina-Gonzalez
Summary: Viscosity plays a determinant role in various industrial fluid processes and is especially important at the micro- and nanoscale. This study focuses on the use of fluorescent molecular rotors to quantitatively measure viscosity in confined and complex microfluidic flows. The technique is validated in controlled situations and then applied to passive micromixers to characterize and quantify mixing efficiency. This methodology provides a new approach for viscosity characterization in heterogeneous and complex systems.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Guiqiang Fei, Shaoqi Li, Yuxia Liu, Jared B. Carney, Tao Chen, Yulin Li, Xiaoyong Gao, Ji Chen, Pu Chen, Yanfeng Yue, Kai Bao, Bo Tang, Guang Chen
Summary: This review discusses the factors influencing mechanically responsive fluorescent materials, including the modulation of aliphatic chains, donor-acceptor structure, substituent adjustment, and position isomerism. By controlling these factors, the desired optical properties can be achieved, providing a significant reference for developing novel, high contrast, and recyclable mechanical response luminous materials.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Markus Pietsch, Kaido Viht, Alexander Schnitzler, Ramesh Ekambaram, Michaela Steinkrueger, Erki Enkvist, Christian Nienberg, Anna Nickelsen, Miriam Lauwers, Joachim Jose, Asko Uri, Karsten Niefind
BIOORGANIC CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Olivier Etebe Nonga, Darja Lavogina, Taavi Ivan, Kaido Viht, Erki Enkvist, Asko Uri
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2020)
Article
Optics
Ines G. Tavares, Erki Enkvist, Joosep Kaimre, Asko Uri, Fernando B. Dias
Summary: This work investigates the intramolecular energy transfer between two thiophene donors and a perylene bisimide acceptor, demonstrating the transfer of energy from the thiophene donor's excited triplet state to the perylene bisimide acceptor's singlet state. The designed organic luminophore, ARC-1467, shows delayed fluorescence of perylene bisimide upon excitation of the donor unit, indicating the occurrence of energy transfer from the triplet state of the donor unit to the perylene bisimide acceptor.
JOURNAL OF LUMINESCENCE
(2021)
Article
Obstetrics & Gynecology
Darja Lavogina, Artjom Stepanjuk, Maire Peters, Kulli Samuel, Sergo Kasvandik, Masuma Khatun, Riikka K. Arffman, Erki Enkvist, Kaido Viht, Sergei Kopanchuk, Freddy Lattekivi, Agne Velthut-Meikas, Asko Uri, Terhi T. Piltonen, Ago Rinken, Andres Salumets
Summary: The study identified elevated ROCK activity in response to combined progesterone and 8-Br-cAMP treatment during in vitro decidualization, leading to increased ROCK2 mRNA and protein levels as well as phosphorylation of its downstream target Cofilin-1. This research highlighted the importance of ROCK as a novel target in decidualization and the need for further investigation, especially in the context of subfertility and infertility related to decidualization.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Olivier E. Nonga, Darja Lavogina, Erki Enkvist, Katrin Kestav, Apirat Chaikuad, Sarah E. Dixon-Clarke, Alex N. Bullock, Sergei Kopanchuk, Taavi Ivan, Ramesh Ekambaram, Kaido Viht, Stefan Knapp, Asko Uri
Summary: The X-ray crystallographic study of PIM-1 protein kinase complexes with three inhibitors revealed simplified chemical structures with reduced polar groups and chiral centers, which showed low-nanomolar potency and high selectivity towards PIM kinases. The developed inhibitors were functionalized with biotin or fluorescent dye Cy5 for detection in biochemical solutions and complex biological samples. Utilizing a PIM-2 selective detection antibody, a sandwich assay was able to detect as low as 44 pg of active recombinant PIM-2.
Article
Chemistry, Medicinal
Tanel Sormus, Darja Lavogina, Anu Teearu, Erki Enkvist, Asko Uri, Kaido Viht
Summary: This study reports the development of the first covalent bisubstrate PK inhibitor that reacts with a distant cysteine residue outside the ATP-binding site. The synthesized inhibitors demonstrated PKA-selectivity and targeting capability in cells.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Darja Lavogina, Naila Nasirova, Tanel Sormus, Taavo Tahtjarv, Erki Enkvist, Kaido Viht, Toiv Haljasorg, Koit Herodes, Jana Jaal, Asko Uri
Summary: In this research, we designed a series of ARCs and their fluorescent derivatives to investigate their interactions with members of the protein arginine methyltransferase (PRMT) family. Our results showed that ARCs and arginine-rich peptides could serve as high-affinity ligands for PRMT1, and the equilibrium dissociation constant values were dependent on the number of arginine residues within the compounds.
JOURNAL OF PEPTIDE SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Tanel Sormus, Darja Lavogina, Erki Enkvist, Asko Uri, Kaido Viht
Summary: Bivalent ligands, such as bisubstrate inhibitors, can simultaneously target two binding sites of a biomolecule and their ability to bind to the biological target can be modulated by an external trigger. This study constructed deactivatable bisubstrate inhibitors of basophilic protein kinases by conjugating pharmacophores via linkers that can be cleaved in response to external stimuli. The inhibitors exhibited high affinity and inhibitory potency towards cAMP-dependent PK (PKAc alpha), which could be reduced by specific external stimuli. These deactivatable inhibitors are valuable tools for the inhibition or capture of pharmacologically important enzymes.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
