Article
Environmental Sciences
Xinyi Wang, Runhui Yang, Jing Zhang, Xianggui Chen, Ying Feng, Yumin Niu, Bing Shao
Summary: The metabolic pathways of a typical fluorinated liquid-crystal monomer (LCM), EDPrB, were investigated in various species. A total of 20 species-dependent metabolites were identified, with dealkylation, H-abstraction, and hydroxylation reactions being the primary metabolic pathways. Toxicity predictions revealed that 17 metabolites were classified as toxic, and some exhibited developmental toxicity and mutagenicity in rats. The results highlight the importance of biotransformation and the need for further toxicological and monitoring studies to assess the ecological and human safety of LCMs.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Analytical
Michal Grabka, Krzysztof Jasek, Mateusz Pasternak
Summary: The study presents the application of PMFOS as a sensor coating in a SAW gas sensor, showing its enhanced ability to interact via acidic hydrogen bond formation. The PMFOS sensor exhibits superior humidity resistance compared to the PLF sensor, indicating its advantages in DMMP sensing in humid air.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Chemical
Qiang Chen, Siting Xia, Yujun Wang, Guangsheng Luo, Hongyong Shang, Kui Wang
Summary: The developed microreactor system allows for efficient continuous synthesis with high yields achieved in a shorter time. By coupling Gaussian software and CFD simulations, the reaction kinetics and yield can be predicted accurately without the need for experimental validation.
Article
Chemistry, Organic
Bhavna Yadav, Beeraiah Baire
Summary: This study reports an Ag(I)-promoted, highly diastereoselective cycloisomerization strategy for the synthesis of indole-derived compounds. The key features of this strategy are its 100% atom economy, access to diverse heterocycles, simple operation, and distinct reactivity of indole vs 7-azaindoles.
Article
Chemistry, Organic
Khagendra B. Hamal, Cyprian I. Pavlich, Graham J. Carlson, Yu Ching Wong, Fangzhou Zhao, Qing Zhang, Kevin K. Klausmeyer, Kevin G. Pinney
Summary: A concise synthesis of the HIF-2α inhibitor belzutifan was achieved by reproducing key components of previous synthetic approaches. Belzutifan, an orally bioavailable small-molecule inhibitor, has been approved by the FDA for the treatment of VHL disease-associated RCC. The synthesis proceeded in good overall yield with high diastereoselectivity, and diastereomeric mixtures were easily separated at different stages of the synthesis.
TETRAHEDRON LETTERS
(2023)
Article
Chemistry, Medicinal
Dongfeng Zhang, Peng Li, Yongxin Gao, Yaoyao Song, Yaqin Zhu, Hong Su, Beibei Yang, Li Li, Gang Li, Ningbo Gong, Yang Lu, Huanjie Shao, Chunrong Yu, Haihong Huang
Summary: Compound 3a-P1, a novel pan-inhibitor, has shown high efficacy in the treatment of chronic myeloid leukemia, especially against the most refractory T315I mutant, with good safety profiles in various assays. It exhibited potent antiproliferative activities and favorable pharmacokinetic properties, suggesting its potential as a promising drug candidate for overcoming imatinib-resistant T315I BCR-ABL mutation in CML treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Navnath S. Gavande, Pamela S. VanderVere-Carozza, Katherine S. Pawelczak, Tyler L. Vernon, Matthew R. Jordan, John J. Turchi
ACS MEDICINAL CHEMISTRY LETTERS
(2020)
Review
Chemistry, Multidisciplinary
Rasha Jwad, Daniel Weissberger, Luke Hunter
Article
Multidisciplinary Sciences
Mitchell S. Quinn, Klaas Nauta, Meredith J. T. Jordan, Joel M. Bowman, Paul L. Houston, Scott H. Kable
Review
Oncology
Isaac J. Powell, Sreenivasa R. Chinni, Sunil S. Reddy, Alexander Zaslavsky, Navnath Gavande
Summary: The study shows that pro-inflammatory cytokine and chemokine genes are more active in African American men and drive the aggressiveness and metastasis of prostate cancer. Further investigation into the biological pathways reveals how these genes impact tumor growth and spread.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Article
Chemistry, Organic
Aggie Lawer, Luke Hunter
Summary: The research found that stereoselective fluorination can influence the helical character of gamma-hexapeptides, stabilizing or disrupting their 9-helical conformation based on C-F stereochemistry and determining the handedness of the helix. These findings provide fundamental knowledge to expedite the future development of backbone-extended peptides for medicinal applications.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Gaurav Joshi, Manisha Sharma, Sourav Kalra, Navnath S. Gavande, Sandeep Singh, Raj Kumar
Summary: The study focuses on the design, synthesis, and anticancer activity of a series of novel xanthine oxidase inhibitors (XOIs). Among the synthesized compounds, 2b and 2m emerged as potent XO inhibitors, demonstrating significant potential for the treatment of XO-harboring tumors. The compounds induced apoptosis, halted cell cycle progression, elevated ROS levels, and altered mitochondrial membrane potential, suggesting promising therapeutic avenues for targeting XO in cancer treatment.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
A. Daryl Ariawan, Flora Mansour, Nicole Richardson, Mohan Bhadbhade, Junming Ho, Luke Hunter
Summary: In this study, new analogs of established but non-selective HDAC inhibitors were created by decorating the central linker chains with specific fluorine atoms to control molecular conformation. These fluorinated analogs were screened against 11 HDAC isoforms, revealing minor differences in isoform selectivity patterns.
Article
Oncology
Pamela S. VanderVere-Carozza, Navnath S. Gavande, Shadia I. Jalal, Karen E. Pollok, Elmira Ekinci, Joshua Heyza, Steve M. Patrick, Andi Masters, John J. Turchi, Katherine S. Pawelczak
Summary: RPA plays important roles in lung cancer as a negative prognostic biomarker and as a predictive marker for chemotherapy response. Second-generation RPA inhibitors show increased cellular permeability and exhibit anticancer activity. Chemical RPA inhibition enhances the activity of various cancer therapeutics.
FRONTIERS IN ONCOLOGY
(2022)
Review
Pharmacology & Pharmacy
Disha Iyengar, Katyayani Tatiparti, Navnath S. Gavande, Samaresh Sau, Arun K. Iyer
Summary: Pancreatic cancer has a low 5-year survival rate due to a lack of early detection and screening options. However, the use of nanoparticle drug delivery systems can improve chemotherapy efficacy without increasing toxicity risks. This has significant implications for the survival rates and prognosis of patients with pancreatic cancer.
DRUG DISCOVERY TODAY
(2022)
Review
Oncology
Jeremy M. Kelm, Amirreza Samarbakhsh, Athira Pillai, Pamela S. VanderVere-Carozza, Hariprasad Aruri, Deepti S. Pandey, Katherine S. Pawelczak, John J. Turchi, Navnath S. Gavande
Summary: This review highlights the recent advances in the development of inhibitors targeting non-PIKKs mediators of DNA repair pathways. These inhibitors have the potential to impact cancer treatment by affecting the efficacy of DNA-damaging drugs and IR, as well as inducing synthetic lethality in HDR-deficient cancer subtypes. Furthermore, these inhibitors may also have applications in precision genome editing.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
Keiran N. Rowell, Scott H. Kable, Meredith J. T. Jordan
Summary: Carbonyls are abundant in the atmosphere and play a crucial role in atmospheric photochemistry. Experimental and theoretical studies suggest that concerted triple fragmentation and H-2 loss pathways in saturated aldehydes have direct implications for global H-2 production, while tautomerisation affects the atmospheric production of organic acids.
ATMOSPHERIC CHEMISTRY AND PHYSICS
(2022)
Article
Chemistry, Organic
Yuvixza Lizarme-Salas, Tsz Tin Yu, Caspar de Bruin-Dickason, Naresh Kumar, Luke Hunter
Summary: In this study, novel QS inhibitor candidates were synthesized with fluorine atoms positioned stereospecifically on the lipidic tail, resulting in molecules biased into conformations pre-organized for binding to the QS receptor. The presence of fluorine significantly increased the QS inhibitory potency.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Navnath S. Gavande, Pamela S. VanderVere-Carozza, Katherine S. Pawelczak, Pamela Mendoza-Munoz, Tyler L. Vernon, Leslyn A. Hanakahi, Matthew Summerlin, Joseph R. Dynlacht, Annabelle H. Farmer, Catherine R. Sears, Nawar Al Nasrallah, Joy Garrett, John J. Turchi
NUCLEIC ACIDS RESEARCH
(2020)
Article
Chemistry, Organic
Yuvixza Lizarme-Salas, Alexandra Daryl Ariawan, Ranjala Ratnayake, Hendrik Luesch, Angela Finch, Luke Hunter
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2020)
Article
Chemistry, Organic
Suo Chen, Yao Ruan, Ji-Liang Lu, Luke Hunter, Xiang-Guo Hu
ORGANIC & BIOMOLECULAR CHEMISTRY
(2020)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
