Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 89, Pages 11014-11016Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc34015a
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A propargyl containing guanosine phosphoramidite was synthesized and incorporated into siRNA, enabling click-ligation with an azido fluorophore onto the nucleobase sugar edge. Duplex stability was not affected by labeling at this new site, which allowed deconvolution of the effects of label, structure and attachment site on RNAi activity.
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