Journal
CHEMICAL COMMUNICATIONS
Volume 48, Issue 40, Pages 4815-4817Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c2cc30622k
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Hirao Taro Foundation of the Konan University Association for Academic Research
- Grants-in-Aid for Scientific Research [24655161, 22655057] Funding Source: KAKEN
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In an equimolar ratio the human telomeric oligonucleotides d[AGGG(TTAGGG)(3)] and d[(CCCTAA)(3)CCCT] formed mixed structures of duplex and tetraplex in bis(2-ethylhexyl) sulfosuccinate reverse micelles; only the duplex was observed in aqueous buffer. This finding suggests that heterogeneous confined media in the cell nucleus might induce a significant fraction of the telomeric region of genomic DNA to adopt non-canonical tetraplex structure.
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