4.7 Article

Label-free and sensitive thrombin sensing on a molecularly grafted aptamer on graphene

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 5, Pages 738-740

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc15429j

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Funding

  1. Jiangsu Higher Education Institutions
  2. National Natural Science Foundations of China [20875047]
  3. MOE Key Laboratory of Analytical Chemistry for Life Science [KLACLS07006]

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A unique nanocomposite was constructed by grafting an aptamer on graphene and used as a label-free biosensor for thrombin sensing, showing good selectivity, a low detection limit of 0.45 fM and high sensitivity, with a linear response up to 100 fM.

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