4.7 Article

Phosphoric acid functionalized mesoporous organo-silica (EPO) as the adsorbent for in situ enrichment and isotope labeling of endogenous phosphopeptides

Journal

CHEMICAL COMMUNICATIONS
Volume 48, Issue 7, Pages 961-963

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc15222j

Keywords

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Funding

  1. National Natural Sciences Foundation of China [20735004, 20875089]
  2. NSFC [21021004]
  3. National Key Special Program on Infection diseases [2008ZX10002-017, 2008ZX10002-020]
  4. MOST [2009IM031800, 2010IM030500]

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Ti4+-EPO nanoparticles were adopted as the adsorbent for in situ solid phase enrichment and isotope labeling of endogenous phosphopeptides, which has great potential application in high-throughput analyses of biological samples for screening and discovery of disease-specific biomarkers.

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