Article
Chemistry, Physical
Seongwook Park, Seunghwan Byun, Huijeoung Ryu, Hyungwoo Hahm, Junseong Lee, Sukwon Hong
Summary: Novel ruthenium catalysts bearing azobenzene groups were developed for olefin metathesis reactions, demonstrating an on-off switching ability in ring-closing metathesis reactions depending on UV irradiation. Various types of olefin metathesis reactions, such as ring-opening metathesis, cross-metathesis, and ethenolysis, exhibited photoswitching phenomena. The reversible feature of photoswitching was confirmed by observing the photoisomerization of azobenzene-bearing cyclic(alkyl)(amino)carbene ligands and the corresponding ruthenium catalysts using UV-vis spectroscopy.
Article
Chemistry, Physical
Felix Ziegler, Hamzeh Kraus, Mathis J. Benedikter, Dongren Wang, Johanna R. Bruckner, Michal Nowakowski, Kilian Weisser, Helena Solodenko, Guido Schmitz, Matthias Bauer, Niels Hansen, Michael R. Buchmeiser
Summary: By utilizing cationic molybdenum imido alkylidene N-heterocyclic carbene (NHC) complexes confined in tailored ordered mesoporous silica, high macrocyclization selectivities up to 98% and high substrate concentrations up to 0.1 M can be achieved. Molecular dynamics simulations reveal that high conversions are a result of the proximity between the surface-bound catalyst and surface-located substrates, leading to increased reaction efficiency.
Article
Chemistry, Physical
Samantha K. Cormier, Deryn E. Fogg
Summary: Ruthenium-promoted ring-opening metathesis polymerization (ROMP) can produce amine-functionalized polymers with antimicrobial, adhesive, and self-healing properties. However, the degradation of intermediates formed in metathesis of terminal olefins is a challenge. This study explores the relevance of these decomposition pathways to ROMP using the third-generation Grubbs catalyst.
Article
Chemistry, Physical
Samantha K. Cormier, Deryn E. Fogg
Summary: Ruthenium-promoted ring-opening metathesis polymerization (ROMP) provides potential routes for amine-functionalized polymers, but the presence of amines leads to degradation of the intermediates formed in metathesis reactions. This study examines the relevance of these degradation pathways to ROMP using the third-generation Grubbs catalyst. Primary alkylamines rapidly inhibit polymerization through fast adduct formation and nucleophilic attack, while bulkier, Bronsted-basic amines are less aggressive. The addition of HCl limits degradation and enables successful ROMP of otherwise challenging monomers.
Article
Chemistry, Organic
Tuong Anh To, Binh Khanh Mai, Thanh Vinh Nguyen
Summary: This article reports a new Bronsted acid-catalyzed carbonyl-olefin metathesis reaction using nitromethane as a solvent, which can promote intramolecular ring-closing reactions.
Article
Chemistry, Multidisciplinary
Kosuke Ono, Satoru Onodera, Hidetoshi Kawai
Summary: A novel synthetic strategy using boroxine formation for large macrocyclic molecules has been developed. This strategy utilizes the boroxine moiety as a covalent template to produce macrocyclic compounds through reactions with alkenyl chains. This method eliminates the need for template molecules and simplifies the synthetic procedure.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Michael Duss, Miguel A. Soto, Brian O. Patrick, Mark J. MacLachlan
Summary: In this study, the polymerization/oligomerization of unstrained macrocycles was achieved using a supramolecular approach, leading selectively to cyclic products by inhibiting the ring-closing reaction back to the monomer. This proof-of-concept enables ring-expansion polymerization of unstrained macrocycles leading to cyclic polymers with molecular weights up to 6700 Da.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Editorial Material
Chemistry, Multidisciplinary
Leah N. N. Appelhans
Summary: Plasmonic heating by nanoparticles has been utilized to enhance various chemical reactions. Now, thermoplasmonic activation has been extended to latent ruthenium catalysts for olefin metathesis triggered by visible and infrared light.
Review
Chemistry, Multidisciplinary
Anna Kajetanowicz, Karol Grela
Summary: This paper introduces a novel subclass of chelating-benzylidene ruthenium catalysts that can be activated by electron-withdrawing groups, providing a highly tunable platform for target-oriented synthesis, medicinal chemistry, fine-chemicals preparation, and materials chemistry. The paper also offers suggestions for end-users on minimizing catalyst loading, controlling selectivity, and optimizing the olefin metathesis reaction based on examples provided.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Adrian Sytniczuk, Mariusz Milewski, Michal Dabrowski, Karol Grela, Anna Kajetanowicz
Summary: A set of macrocyclic unsaturated musk compounds were obtained through a high-concentration RCM process, achieved by forming oligomers and then undergoing backbiting metathesis reaction. The process exhibited high selectivity and yielded pure macrocyclic musk products. The reaction conditions were user-friendly and environmentally friendly, using commercially available catalyst and bio-sourced oleic acid substrates.
Review
Chemistry, Applied
Kamal M. Dawood, Kotohiro Nomura
Summary: This review article summarizes the effects of different catalysts on Z-selective olefin metathesis reactions and the essential roles of ligand modifications in achieving stereospecific reactions.
ADVANCED SYNTHESIS & CATALYSIS
(2021)
Article
Chemistry, Multidisciplinary
Henrik Gulyas, Shigetaka Hayano, Adam Madarasz, Imre Papai, Mark Szabo, Agota Bucsai, Eddy Martin, Jordi Benet-Buchholz
Summary: By tuning the electron donor capacity of ligands, air-stable solid adducts of tungsten and molybdenum alkylidenes can be prepared, which can spontaneously release active catalysts in solution.
COMMUNICATIONS CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Stefan Czarnocki, Louis Monsigny, Michal Sienkiewicz, Anna Kajetanowicz, Karol Grela
Summary: A modular and flexible strategy for synthesizing N-heterocyclic carbene (NHC) ligands bearing Bronsted base tags has been proposed and used to prepare two tagged NHC ligands with different acid residues. These tagged NHC ligands serve as an attractive starting point for the synthesis of olefin metathesis ruthenium catalysts with non-dissociating ligands. The impact of the Bronsted base tags on the activity of the obtained olefin metathesis catalysts has been investigated.
Article
Biochemistry & Molecular Biology
Ervin Kovacs, Bence Balterer, Nguyen Anh Duc, Gyorgyi Szarka, Michael C. Owen, Attila Domjan, Bela Ivan
Summary: A large number of organic solvents contaminate the environment on a daily basis worldwide. This study demonstrates that benzotrifluoride can be used as a suitable solvent for olefin metathesis reactions, providing high yields and similar or even higher reaction rates compared to dichloromethane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Pushparaj Loganathan, Renjith S. Pillai, G. Abigail Jennifer, Elumalai Varathan, M. Kesavan, Swaminathan Shanmugan
Summary: The development of multifunctional catalysts for one-pot tandem reactions is of significant importance in the chemical industry. In this study, a homogenous bifunctional acid-base catalyst, Al-POSS-NH2, was synthesized and successfully used for one-pot tandem reactions. The catalyst showed high efficiency and reusability, with the advantage of easy separation from the reaction mixture. The study suggests that bifunctional POSS could facilitate the development of environmentally friendly and economically feasible catalysts for multistep reactions.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Shee Chee Ong, Alessia Belgi, Bianca van Lierop, Carlie Delaine, Sofianos Andrikopoulos, Christopher A. MacRaild, Raymond S. Norton, Naomi L. Haworth, Andrea J. Robinson, Briony E. Forbes
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Article
Biochemical Research Methods
Bo Zhang, Giancarlo Pascali, Naomi Wyatt, Lidia Matesic, Mitchell A. Klenner, Tiffany R. Sia, Adam J. Guastella, Massimiliano Massi, Andrea J. Robinson, Benjamin H. Fraser
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
(2018)
Article
Chemistry, Multidisciplinary
Bo Zhang, Benjamin H. Fraser, Mitchell A. Klenner, Zhen Chen, Steven H. Liang, Massimiliano Massi, Andrea J. Robinson, Giancarlo Pascali
CHEMISTRY-A EUROPEAN JOURNAL
(2019)
Article
Chemistry, Multidisciplinary
Kandala Laxman, B. Pradeep K. Reddy, Andrea Robinson, Rohit Srivastava, Mangalampalli Ravikanth
Article
Chemistry, Medicinal
Gopal R. Sama, Hongbin Liu, Simon Mountford, Phillip Thompson, Andrea Robinson, Anthony E. Dear
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2020)
Article
Chemistry, Medicinal
Kandala Laxman, B. Pradeep K. Reddy, Andrea Robinson, Rohit Srivastava, Mangalampalli Ravikanth
Review
Food Science & Technology
Adam C. Kennedy, Alessia Belgi, Benjamin W. Husselbee, David Spanswick, Raymond S. Norton, Andrea J. Robinson
Article
Materials Science, Multidisciplinary
Kandala Laxman, B. Pradeep K. Reddy, Sumit K. Mishra, Andrea Robinson, Abhijit De, Rohit Srivastava, Mangalampalli Ravikanth
NPG ASIA MATERIALS
(2020)
Article
Cardiac & Cardiovascular Systems
HongBin Liu, Gopal R. Sama, Andrea Robinson, Simon Mountford, Philip E. Thompson, Andrew Rodda, John Forsythe, Patrick J. Mornane, Paul Pasic, Helmut Thissen, Melissa Byrne, David M. Kaye, Anthony E. Dear
Summary: PTX-coated drug eluting balloon catheters (DEBc) used for neointimal hyperplasia (NIH) management have safety concerns. A novel DEBc, Lumi-Solve, coated with UV 365 nm-activated caged metacept-3 (c-MCT-3), showed potential for targeted delivery of bioactive HDACi, supporting direct application to NIH management, warranting further in vivo studies.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2021)
Article
Chemistry, Medicinal
Alessia Belgi, James Burnley, Christopher A. MacRaild, Sandeep Chhabra, Khaled A. Elnahriry, Samuel D. Robinson, Simon G. Gooding, Han-Shen Tae, Peter Bartels, Mahsa Sadeghi, Fei-Yue Zhao, Haifeng Wei, David Spanswick, David J. Adams, Raymond S. Norton, Andrea J. Robinson
Summary: This study successfully modified the disulfide framework of alpha-conotoxin to generate a potent GABA(B) receptor agonist, which can inhibit Ca(v)2.2 channels to treat neuropathic pain and exhibit dose-dependent reversal of mechanical allodynia in a behavioral rat model. The findings support the hypothesis that analgesia can be achieved by activating GABA(B)Rs in DRG sensory neurons.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Martin G. Banwell, Brett D. Schwartz, Alex C. Bissember, Tony Herlt, Anthony C. Willis, Michael G. Gardiner, Jayamini Illesinghe, Andrea J. Robinson
Summary: Different forms of 2-amino-3-(8-hydroxyquinolin-3-yl)-propanoic acid were prepared from o-methoxyacetanilide through a series of reactions. The structure, including absolute configuration, of one form was confirmed through single-crystal X-ray analysis of the corresponding HBr mono salt.
ASIAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Yudhi D. Kurniawan, Kellie L. Tuck, Sergio Castillon, Andrea J. Robinson
Summary: This paper describes a convergent synthesis of the C-3-C-8 fragment of zaragozic acids, involving key reactions such as desilylation-aldol reaction, rearrangement induced by regioselective reductive cleavage, BAIB/TEMPO-Pinnick oxidation, esterification, silylation, and hydrogenolysis.
TETRAHEDRON LETTERS
(2021)
Article
Microbiology
Megan J. Allman, Aidan J. Slack, Nigel P. Abello, Ya-Hsun Lin, Scott L. O'Neill, Andrea J. Robinson, Heather A. Flores, D. Albert Joubert
Summary: This study tested a more environmentally friendly approach to mosquito rearing and release by encapsulating diet and egg mixtures and utilizing waste containers. The results showed that different types of waste containers maintained the health and reproductive capacity of mosquitoes, making this method culturally and economically feasible for implementation in Pacific Islands.
Article
Chemistry, Multidisciplinary
Amy L. Thomson, Ellen C. Gleeson, Alessia Belgi, W. Roy Jackson, Ekaterina I. Izgorodina, Andrea J. Robinson
Summary: Ru-Alkylidene catalysed olefin metathesis can generate metabolically stable peptidomimetics with defined geometry of cystine bridge. By in situ and reversible oxidation of thiol and thioether functionality to disulfides and S-oxides, respectively, the deleterious coordinative bonding between sulfur-containing functionality found in cysteine and methionine residues and the catalyst can be negated, facilitating high yielding ring-closing and cross metathesis of bioorthogonally protected peptides.
CHEMICAL COMMUNICATIONS
(2023)
Article
Nanoscience & Nanotechnology
Kandala Laxman, B. Pradeep K. Reddy, Sumit K. Mishra, Maddala Bala Gopal, Andrea Robinson, Abhijit De, Rohit Srivastava, Mangalampalli Ravikanth
ACS APPLIED MATERIALS & INTERFACES
(2020)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
