Article
Chemistry, Analytical
Fenying Wang, Shuqing Xiong, Tingting Wang, Yadan Hou, Qianjin Li
Summary: In this study, a simple method using phenylboronic acid-functionalized fluorescent molecules and principal component analysis (PCA) was used to discriminate different types of cis-diols. By combining fluorescence response data and quenching constants with molecular weight, successful differentiation and identification of different types of cis-diols were achieved.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Fenying Wang, Shuqing Xiong, Tingting Wang, Yadan Hou, Qianjin Li
Summary: In this study, the discrimination and identification of different types of cis-diols were successfully achieved by combining fluorescent boronate affinity molecules with principal component analysis. By optimizing the fluorescence response data and quenching constants, the specific recognition capability of boronic acids was greatly improved, providing a simple and intuitive method for distinguishing and identifying different types of cis-diols.
ANALYTICAL METHODS
(2023)
Article
Chemistry, Analytical
Yunchun Liu, Liyun Hua, Wanru Zhu, Chen Liu, Hongrui You, Hongqi Chen
Summary: UiO-66-NH2 nanocomposite was post-modified with 4-mercaptophenylboronic acid (MPBA) by in situ hybridization reaction to create the hybrid boronate affinity material UiO-NH2@P (TEPIC-co-MPBA), which exhibited high specific selectively. This material was utilized as a fluorescent probe for detecting cis-diol containing compounds in tea beverages, demonstrating good linearity and a low detection limit.
Article
Chemistry, Analytical
Zewei Yao, Mao Li, Yao Sun, Chaozhan Wang, Yinmao Wei
Summary: This study developed a restricted-access boronate affinity mesoporous adsorbent with high binding capacities for small cis-diol-containing molecules. The adsorbent selectively extracts cis-diols from biosamples while excluding proteins completely. The adsorbent was successfully used in analyzing nucleosides and cis-diol drugs in human serum, simplifying the analysis process.
Article
Biochemical Research Methods
Zhian Sun, Yao Sun, Jiwei Shen, Chaozhan Wang, Yinmao Wei
Summary: A new analytical method has been proposed in this study, which can simultaneously enrich and determine the concentrations of multiple substances in a single extraction process. This method is simple to operate, consumes less samples, and has high sensitivity and accuracy.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemical Research Methods
Hainan Zeng, Xue Yu, Junfen Wan, Xuejun Cao
Summary: This research successfully synthesized a molecularly imprinted polymer (MIP) based on boronate affinity for tylosin, with high adsorption capacity, fast pH-responsiveness, and high selectivity for tylosin. The MIP method has great application potential in the separation and purification of diol-containing macrolide antibiotics.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Chemistry, Inorganic & Nuclear
Jakub P. Sek, Sabina Kaczmarczyk, Katarzyna Gunka, Agata Kowalczyk, Krzysztof M. Borys, Artur Kasprzak, Anna M. Nowick
Summary: In this research, polyamidoamine dendrimers and polyethyleneimine polymers doped with phenylboronic derivatives were used as molecular receptors for voltammetric glucose detection, with wide linearity range and low detection limits. Interference tests showed that fructose had a significant impact on the oxidation signal of ferrocene units, specifically in systems with low boron content, forming complexes with glucose in a 1:1 stoichiometric ratio. The developed electrochemical sensors showed high accuracy and reliability for real-life sample analysis.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Analytical
Daojin Li, Sihan Dong
Summary: Traditional boronate affinity materials for cis-diol-containing biomolecules suffer from low binding affinity and require a basic binding pH, while 6-aminopyridine-3-boronic acid functionalized magnetic nanoparticles show high binding affinity and a low binding pH. This new material allows for selective extraction of cis-diol-containing biomolecules from samples with low concentrations under neutral or acidic conditions, demonstrating practical applications for enrichment in real samples.
ANALYTICAL METHODS
(2021)
Article
Materials Science, Multidisciplinary
Dan Wang, Yun Qu, Fenying Wang, Qianjin Li, Qianyong Cao
Summary: Boronate affinity materials (BAMs) have important applications in separation, sensing, imaging, diagnostics, and drug delivery. This study investigated the effects of polymerization solvents and crosslinker types on the binding selectivity of PBA-functionalized polymers. It was found that PBA-MBAA particles synthesized in DMSO displayed ultrahigh selectivity to cis-diol containing molecules. This study provides a new method for producing highly selective BAMs.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Analytical
Pengcheng Wu, Jiaren Song, Wanchao Zuo, Jiaying Zhu, Xiangming Meng, Jun Yang, Xinmei Liu, Hui Jiang, Donghui Zhang, Jianjun Dai, Yanmin Ju
Summary: A boronate affinity-based lateral flow immunoassay (LFIA) without the need for capture antibodies was developed for the detection of glycoproteins. The LFIA labels, 4-MPBA-AuNPs, showed excellent binding capability and cost advantages compared to capture antibodies. The developed LFIA achieved a lower limit of detection for carcinoembryonic antigen (CEA) and demonstrated high accuracy in detecting CEA-positive samples in a nonlaboratory environment. Thus, this diagnostic platform provides an effective tool for point-of-care glycoprotein detection.
Article
Chemistry, Multidisciplinary
Pengfei Li, Shuxin Xu, Yanjie Han, Hui He, Zhen Liu
Summary: A machine learning-empowered mass spectrometry platform was developed for accurate profiling and quantification of cis-diol metabolites associated with liver cancer. The platform improved the detection coverage and demonstrated higher sensitivity and specificity in diagnosing liver cancer compared to protein biomarker-based methods.
Article
Chemistry, Analytical
Ziyi Wang, Ting Zou, Shitao Feng, Fengshou Wu, Juan Zhang
Summary: A boronic acid-functionalized magnetic porphyrin-based covalent organic framework (COF) was synthesized for the selective enrichment and detection of nucleosides. The COF was grown on Fe3O4-NH2 nanospheres and boronic acid was introduced via Suzuki-Miyaura cross-coupling reaction. The prepared COF showed a core-shell structure and had high affinity for cis-diol-containing nucleosides.
ANALYTICA CHIMICA ACTA
(2023)
Article
Engineering, Chemical
Shucheng Liu, Zhi Hu, Xuan Zhang, Nana Tang, Hongxiang Ou, Jianming Pan
Summary: A new kind of porous block imprinted copolymers with abundant boronic acid recognizing sites were synthesized for specific separation of ovalbumin. The copolymers exhibited high adsorption capacity, fast kinetics, and excellent selective adsorption performance, making them a promising option for glycoproteins enrichment from complex samples.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Biochemical Research Methods
Shitao Feng, An Zhang, Fengshou Wu, Xiaogang Luo, Juan Zhang
Summary: Boronic acid grafted Zr-MOF (BA-Zr-MOF) was constructed using a simple pre-installation strategy and showed excellent selectivity for cis -diol-containing compounds. A method based on BA-Zr-MOF for analysis of nucleosides was established, which demonstrated high adsorption capacity and low detection limits. The reliability of the method was confirmed through urine sample analysis.
JOURNAL OF CHROMATOGRAPHY A
(2022)
Article
Chemistry, Physical
Yao Zhu, Zhiyuan Pan, Jian Rong, Kaili Mao, Dongya Yang, Tao Zhang, Jicheng Xu, Fengxian Qiu, Jianming Pan
Summary: A boronate affinity adsorbent based on surface molecular imprinted polymers (MIPs) was prepared for rapid recognition and selective separation of shikimic acid. The MIPs material showed high adsorption capacity and superior selectivity, making it a promising material for specific capture of shikimic acid with enhanced reusability.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Review
Chemistry, Analytical
Hengye Li, Hui He, Zhen Liu
Summary: Molecules containing cis-diols are of great biological significance but face challenges in analysis due to their low abundance and complex biosamples. Boronate affinity materials (BAMs) have pH-controlled, covalent, and reversible binding properties, making them highly suitable for specific capture, recognition, labeling, and assay of cis-diol containing molecules. Recent efforts to improve the performance of BAMs have led to various promising applications in bioanalysis.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Haifeng Lu, Shuxin Xu, Zhanchen Guo, Menghuan Zhao, Zhen Liu
Summary: The study introduces a novel protein delivery strategy using sialic acid-imprinted biodegradable silica nanoparticles, showing targeted cancer therapy potential by effectively encapsulating cytotoxic protein RNase A. The nanovectors exhibited specific tumor-targeting ability and enhanced cell cytotoxicity, providing a promising platform for biomacromolecule delivery in cancer therapy.
Article
Chemistry, Multidisciplinary
Pengfei Li, Jilei Pang, Shuxin Xu, Hui He, Yanyan Ma, Zhen Liu
Summary: Researchers have developed a dual-modal ratiometric immunoassay based on MIPs for precise diagnosis of hepatocellular carcinoma (HCC). This assay exhibits improved precision compared to traditional ELISA, providing a glycoform-resolved method for HCC diagnosis and a new paradigm for developing antibody mimics via molecular imprinting.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Shuxin Xu, Hui He, Zhen Iiu
Summary: The development of biomimetic affinity materials has significant value in both scientific research and practical applications. By using boronic acid chemistry, a series of boronate affinity materials (BAMs) with desired binding properties have been developed. MIPs and aptamers based on BAMs have been designed and prepared for targeting vital biomolecules. These affinity reagents, combined with advanced analytical techniques, have enabled the construction of promising analytical methods for challenging applications, such as targeted proteomics analysis, single cell analysis, and disease diagnostics. Additionally, the targeting capability of nanoscale MIPs has provided a unique approach for the development of innovative nanotherapeutics for cancer treatment.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Materials Science, Biomaterials
Xinpei He, Qi Luo, Zhanchen Guo, Ying Li, Zhen Liu
Summary: This study presents a new strategy for the rational design and preparation of molecularly imprinted mesoporous silica nanoparticles that can mimic the functions of enzymes. This strategy enhances the effective collision probability of substrates and enables continuous product amplification through thermal cycling. As a result, the reaction speed is significantly improved and sequence specificity is enhanced.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Multidisciplinary Sciences
Rongrong Xing, Zhanchen Guo, Haifeng Lu, Qi Zhang, Zhen Liu
Summary: Molecularly imprinted polymers (MIPs) are important antibody mimics, but the current molecular imprinting technology faces a compromise between affinity and specificity. This study presents a new strategy called molecular imprinting and cladding (MIC), which improves the affinity and specificity of MIPs by generating a chemically inert cladding layer. The proposed strategy and method were successfully applied to engineer protein binders and demonstrated potential applications in disease diagnosis and nanomedicine.
Article
Chemistry, Analytical
Yanyan Ma, Zhanchen Guo, Chuanwen Fan, Jingran Chen, Shuxin Xu, Zhen Liu
Summary: This study developed aptamers that can target ABCG2 and reverse multidrug resistance, showing great potential in cancer diagnosis and treatment. The aptamers can specifically bind to human colorectal cancer stem cells and effectively reverse drug resistance in liver cancer cells.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Zhanchen Guo, Qi Luo, Zhen Liu
Summary: This study reports a new approach, reverse microemulsion template docking surface imprinting, for the rational design and engineering of nanozymes with free substrate access. The method successfully prepared nanozymes with enhanced catalytic activity and good sequence selectivity.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Analytical
Zhanchen Guo, Menghuan Zhao, Zhen Liu
Summary: A new method for preparing high-affinity nanoscale binders targeting gangliosides is proposed. The prepared nanoparticles exhibit high affinity and specificity towards gangliosides and show potential in biomedical applications such as cell and tissue imaging.
Review
Chemistry, Analytical
Yanrong Wen, Dan Xie, Zhen Liu
Summary: Single cell analysis is a unique window to examine the mechanisms and heterogeneity of molecular biology. Monitoring changes in biomolecules in living cells is crucial for understanding cell signaling dynamics and cellular physiology. Technical advances have provided a basis for exploring the complexities of biological processes and gaining new insights into complex biological systems.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Haifeng Lu, Shuxin Xu, Ge Ge, Zhanchen Guo, Menghuan Zhao, Zhen Liu
Summary: This study presents Cu2+-encapsulated and GalNAc-imprinted biodegradable silica nanoparticles for enhancing chemodynamic therapy (CDT). The nanoparticles specifically target tumor cells and release Cu2+/Cu+ to promote GSH depletion and generate hydroxyl radicals, leading to apoptosis of tumor cells. In vitro and in vivo experiments demonstrate excellent cytotoxicity against tumor cells and high efficacy of tumor inhibition.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Analytical
Dan Xie, Yanrong Wen, Jingran Chen, Haifeng Lu, Hui He, Zhen Liu
Summary: This study developed a new method called plasmonic affinity sandwich assay for the detection of Q-modified tRNAs in single living cells. The method combines plasmon-enhanced Raman scattering detection, base pairing affinity in-cell microextraction, and a set of specific nanotags for the selective recognition of individual Q modifications. This method provides a promising tool for the exploration of the roles and mechanisms of Q-modified tRNAs.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Shuxin Xu, Menghuan Zhao, Zikuan Gu, Haifeng Lu, Zhen Liu
Summary: This study reports the construction of polySia-targeting nanomissiles via molecular imprinting for the photothermal therapy of neuroblastoma. The nanomissiles specifically recognize polySia and target neuroblastoma cells with overexpressed polySia, showing promising potential for targeted therapy of neuroblastoma.
Article
Chemistry, Multidisciplinary
Zikuan Gu, Shuxin Xu, Zhanchen Guo, Zhen Liu
Summary: This study presents a molecularly imprinted polymer-based PD-1 nano inhibitor, which effectively blocks the PD-1/PD-L1 signaling pathway with good specificity and high affinity. The inhibitor can reactivate T cells and reverse the chemoresistance of tumor cells, providing a promising option for cancer immunotherapy.
Article
Chemistry, Multidisciplinary
Jilei Pang, Pengfei Li, Hui He, Shuxin Xu, Zhen Liu
Summary: Accurate analysis of protein biomarkers' glycosylation status is important for precise and early diagnosis of cancer. This study presents a triple MIP-based plasmonic immunosandwich assay (triMIP-PISA) that can detect AFP and AFP-L3 simultaneously in serum, distinguishing hepatocellular carcinoma patients from healthy individuals.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
