4.7 Article

Synthesis of the ABH rings of ecteinascidin 597 using a connective Pummerer-type cyclisation

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 38, Pages 10821-10823

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc13992d

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Funding

  1. EPSRC
  2. GSK
  3. University of Medicine and Pharmacy
  4. Ho Chi Minh City
  5. University of Manchester
  6. Engineering and Physical Sciences Research Council [EP/G015287/1] Funding Source: researchfish
  7. EPSRC [EP/G015287/1] Funding Source: UKRI

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A connective Pummerer-type cyclisation involving a cysteine derivative and an N-benzyl glyoxamide 3 has been applied in an asymmetric synthesis of the protected ABH rings 2 of the antitumour and antimicrobial natural product ecteinascidin 597.

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