Article
Chemistry, Analytical
Asaad S. Mohamed, Osama M. Habib, Nouria A. Al-Awadi
Summary: Flash vacuum pyrolysis of various aryl propargyl ethers with different substituents was investigated, and mechanisms for some reactions were proposed.
JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
(2022)
Article
Chemistry, Multidisciplinary
Helgi Freyr Jonsson, Thomas Nordbo Solvi, Sondre Lomeland, Ann Christin Reiersolmoen, Anne Fiksdahl
Summary: Gold-catalyzed transformations of 1,3-diarylpropargyl alcohols with various aryl nucleophiles were studied. Selective synthetic methods were developed for the synthesis of 1,1,3-triarylallenes, diaryl-indenes, and tetraaryl-allyl target products. The reactions were influenced by the choice of gold catalysts, solvent, temperature, and the electronic and steric effects of the starting materials. High yields of triaryl-allenes and diaryl-indenes were obtained using gold(III) catalysis. Different product ratios were obtained by varying the aryl nucleophile and reaction temperature. Tetraaryl-allyl target products were formed through a sequential one-pot tandem process using appropriate propargyl substrates and two different aryl nucleophiles. Halo-arylation products were obtained in a one-pot manner in the presence of N-halosuccinimides.
Article
Chemistry, Physical
Luong Xuan Dien, Toru Murayama, Nguyen Tuan Hung, Quang Duc Truong, Huynh Dang Chinh, Masamichi Yoshimura, Masatake Haruta, Tamao Ishida
Summary: Gold nanoparticles supported on titania catalysts were prepared using the solid grinding method, and the catalytic activity was improved by treatment with potassium tert-butoxide. The catalyst exhibited high catalytic activity and stability for CO oxidation.
JOURNAL OF CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Sara Fernandez-Moyano, Guillermo Marcos-Ayuso, Marconi N. Penas-Defrutos, Camino Bartolome, Pablo Espinet
Summary: F-19 NMR monitoring reveals that heating trans-[Au(III)Rf(2)I(2)](-) solutions (Rf = C6F3Cl2-3,5) leads to the formation of cis-[AuRf(2)I(2)](-), [AuRf(3)I](-), and [AuRfI(3)](-) via kinetic competition between isomerization and Rf/I scrambling. The easy reductive elimination of Rf-I from [AuRfI(3)](-) (also forming [AuI2](-)) drives the system evolution, providing faster kinetics than any Rf-Rf couplings from the coexisting species, which hinders the desired thermodynamically preferred C-C coupling. A kinetic model is proposed, where I- dissociation triggers both isomerization and transmetalation steps, which is consistent with the experimental data. DFT calculations support that the lower bond strength of Au-III-I compared to other halides leads to a pathway switch, making C-I coupling kinetically preferred. Therefore, it is advisable to avoid C-I coupling in reactions seeking C-C coupling.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Saravanan Krishnan, Paresh N. Patel, Kalpattu K. Balasubramanian, Anju Chadha
Summary: The CpGNP catalyst, prepared by a simple and green method, can selectively reduce nitroarenes and substituted nitroarenes with different functional groups, yielding aryl amines useful for the preparation of pharmaceuticals, polymers, and agrochemicals in high yields under mild conditions. The catalyst exhibits high recyclability, robustness, and long-term stability without any loss in catalytic activity after storage for eight months.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Organic
Wenjing Pan, Chenchen Li, Haoyin Zhu, Fangfang Li, Tao Li, Wanxiang Zhao
Summary: The method described in the paper utilizes HPPh2 and (BuOK)-Bu-t for the demethylation, debenzylation, and deallylation of aryl ethers. It offers mild and metal-free reaction conditions, broad substrate scope, good functional group compatibility, and high chemical selectivity towards aryl ethers. Additionally, the approach can selectively deprotect the allyl or benzyl group, making it a versatile and practical method in organic synthesis.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jamie A. Cadge, John F. Bower, Christopher A. Russell
Summary: A combined theoretical and experimental investigation revealed an unusual mechanism of aryl iodide oxidative addition to gold complexes. The comparison between gold and palladium demonstrated significant differences in reaction rates and mechanisms, suggesting that gold could potentially facilitate a broad range of new or complementary transformations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Motohiro Yasui, Naoko Tahara, Hiroshi Matsubara, Norihiko Takeda, Masafumi Ueda
Summary: This study developed a sequential gold-catalyzed reaction for synthesizing 4-aryl-3-(2H)-isoxazolones with a hydroxy group. The method allows the introduction of an aryl and hydroxy group in a single procedure, exhibiting good chemoselectivity and tolerance towards reactive functional groups.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Physical
Xincheng Li, Ruiyi Wang, Jin Zhang, Jing Wang, Yunwei Wang, Zhanfeng Zheng
Summary: This study presents the design of an efficient photocatalyst, Ni2P/TiO2, for the selective hydrogenation of phenylacetylene to styrene. The catalyst exhibits excellent photocatalytic activity and selectivity, attributed to the isolation and electronic effect of P introduced in the catalyst.
CATALYSIS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Leiduan Hao, Anika Auni, Guodong Ding, Xiaoyu Li, Haiping Xu, Tao Li, Qiang Zhang
Summary: In this study, a new type of catalyst Cu-ZnO-ZrO2 was used for the hydroxylation reaction of aromatic iodides under mild conditions without the need for additional organic ligands or protection of an inert atmosphere. The catalyst is easily prepared, scalable, and highly efficient for a wide range of substrates, showing great potential for mass production with only 1.24 mol% Cu loading.
Article
Chemistry, Multidisciplinary
Kang Xia, Takafumi Yatabe, Kentaro Yonesato, Tomohiro Yabe, Soichi Kikkawa, Seiji Yamazoe, Ayako Nakata, Kazuya Yamaguchi, Kosuke Suzuki
Summary: A feasible method was developed for preparing supported anionic gold nanoparticle catalysts using multivacant lacunary polyoxometalates, confirming the strong electronic interaction between gold nanoparticles and the polyoxometalates, allowing for sequential modulation of the electronic states of the catalysts. The catalyst prepared using [SiW9O34](10-) showed superior catalytic performance and stability compared to supported gold nanoparticle catalysts without this modification.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
R. Camposeco, R. Zanella
Summary: The effect of gold nanoparticles supported on V2O5/TiO2 nanomaterials prepared by different routes and its activity in the CO oxidation at low temperature were studied. The sol-gel Au-V2O5/TiO2 material exhibited higher catalytic activity, especially after thermal treatment, compared to other materials such as Au-V2O5/NT nanotubes, Au-V2O5/P25 Evonik, V2O5/TiO2 nanomaterials, and Au/TiO2 catalyst. The improved catalytic activity can be attributed to the interaction between vanadium species and TiO2, facilitated by the presence of gold species, which allows for high vanadium oxidation states and charge transfer effects.
Article
Environmental Sciences
Roberto Camposeco, Rodolfo Zanella
Summary: This work demonstrates the versatility of a TiO2-Al2O3 mixed oxide with highly dispersed gold nanoparticles for the CO oxidation reaction at room temperature. The addition of Al2O3 in TiO2 improves the textural properties and stability of the catalyst, while gold nanoparticles interact with the support through charge transfer. These findings contribute to the understanding and development of gold catalysts supported on mixed oxide catalysts.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Jie Li, Shiyi Wang, Huayin Li, Yuan Tan, Yunjie Ding
Summary: In this study, Zn-Mg-Al mixed oxides with supported gold nanoclusters were prepared for the direct oxidative esterification of aldehyde and alcohol. The presence of small amounts of Zn2+ ions enhanced the interaction between gold and the support, reducing the particle size of gold. The Au-25/Zn0.05MgAl-400 catalyst showed the best performance in the oxidative esterification reaction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Physical
Mi Yoo, Eunji Kang, Hyuk Choi, Hyunwoo Ha, Hanseul Choi, Jin-Seok Choi, Kug-Seung Lee, Richard Celestre, David A. Shapiro, Jeong Young Park, Chunjoong Kim, Young-Sang Yu, Hyun You Kim
Summary: The study addresses controversies surrounding single-atom catalysts and provides insights on how to enhance their activity and stability through interface control methods. The results demonstrate a novel strategy for improving the catalytic properties of Pt-SAs and monitoring their performance through the chemical state of interfaces, enabling sustainable use of Pt in heterogeneous catalysts.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Chemistry, Organic
Michael G. Kallitsakis, Dimitris I. Ioannou, Michael A. Terzidis, George E. Kostakis, Ioannis N. Lykakis
Article
Chemistry, Organic
Dimitris I. Ioannou, Dimitra K. Gioftsidou, Vasiliki E. Tsina, Michael G. Kallitsakis, Antonios G. Hatzidimitriou, Michael A. Terzidis, Panagiotis A. Angaridis, Ioannis N. Lykakis
Summary: A new study reports an efficient catalytic protocol using methylhydrazine as a reducing agent and tris(N-heterocyclic thioamidate) Co(III) complex as a catalyst to selectively reduce nitroarenes to arylamines with high yields and chemoselectivity. Preliminary investigations suggest a cooperative action of methylhydrazine and the catalyst through a coordination activation pathway, leading to the formation of a reduced cobalt species responsible for the catalytic transformation.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Marina A. Tzani, Catherine Gabriel, Ioannis N. Lykakis
Article
Chemistry, Organic
Dimitrios Andreou, Nsikak B. Essien, Cristina Pubill-Ulldemolins, Michael A. Terzidis, Athanasios N. Papadopoulos, George E. Kostakis, Ioannis N. Lykakis
Summary: A copper-mediated method was developed for the synthesis of seven-membered-ring fused pyrroles, allowing for the tolerance of various functional groups in the derivatives and exhibiting high antioxidant activity in selected examples. These rare 7-mrFPs can now be accessed on a millimolar scale.
Article
Chemistry, Organic
Marina A. Tzani, Stella Fountoulaki, Ioannis N. Lykakis
Summary: In this study, we investigated the catalytic efficacy of silicotungstic acid as a polyoxometalate towards the synthesis of trans-DACPs. Our results demonstrate that this method offers a highly efficient and versatile approach for the synthesis of trans-DACPs with excellent yields.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Marina A. Tzani, Dimitra K. Gioftsidou, Michael G. Kallitsakis, Nikolaos V. Pliatsios, Natasa P. Kalogiouri, Panagiotis A. Angaridis, Ioannis N. Lykakis, Michael A. Terzidis
Summary: This review explores the mechanisms and applications of chemiluminescence, including both direct and indirect production modes. It discusses the characteristics of chemical reactions and CL mechanisms, summarizes methods to enhance CL efficiency, and examines the role of CL in the development of therapeutic platforms.
Article
Chemistry, Multidisciplinary
Vassiliki Daikopoulou, Euaggelia Skliri, Eirini D. Koutsouroubi, Gerasimos S. Armatas, Ioannis N. Lykakis
Summary: This study reports the synthesis and catalytic application of mesoporous Au-loaded Mn3O4 nanoparticle assemblies with different Au contents for the selective oxidation of anilines into nitroarenes. The results show that Au/Mn3O4 MNAs containing 0.5 wt % Au exhibit the best catalytic performance among different catalysts, leading to high yields and selectivity of the corresponding nitroarenes.
Article
Biochemistry & Molecular Biology
Domna Iordanidou, Michael G. Kallitsakis, Marina A. Tzani, Dimitris I. Ioannou, Tryfon Zarganes-Tzitzikas, Constantinos G. Neochoritis, Alexander Domling, Michael A. Terzidis, Ioannis N. Lykakis
Summary: This study reported the synthesis of 3,4-dihydroquinoxalin-2-ones through the selective reduction reaction catalyzed by supported gold nanoparticles. The reaction proceeded through heterogeneous transfer hydrogenation and intramolecular C-N transamidation, resulting in good functional-group tolerance and high yields.
Review
Chemistry, Physical
Jonathan Farhi, Ioannis N. Lykakis, George E. Kostakis
Summary: This study summarizes the multicomponent reaction of aldehydes, amines, and alkynes, known as A(3) coupling, and discusses the application and impact of metal-based catalytic systems in this transformation. By classifying substrates, synthetic methods, and various variables, a valuable database is created.
Article
Oncology
Ioanna Tremi, Sophia Havaki, Sofia Georgitsopoulou, Georgia Terzoudi, Ioannis N. Lykakis, George Iliakis, Vasilios Georgakilas, Vassilis G. Gorgoulis, Alexandros G. Georgakilas
Summary: In this study, gold nanoparticles were found to act as radiation sensitizers, significantly reducing the colony-forming ability of cancer cells and causing higher levels of DNA damage. The nanoparticles also affected cell cycle distribution and cellular senescence. Different cell lines and types of gold nanoparticles may alter the level of radiosensitization.
Article
Chemistry, Organic
Aleksander R. Bena, Evangelos G. Bakalbassis, Michail M. Sigalas, Ioannis N. Lykakis
Summary: We report a one-pot strategy for the synthesis of 3-carboxyl and 3-ketopyridines using readily available alkynes and propargylamine. The protocol is conducted in aqueous media and open-air conditions, and offers a broad substrate scope. Various aryl- and alkyl-substituted pyridines were successfully synthesized, including the natural product core 4-aza-fluorenone. Mechanistic studies support a domino hydroamination/pericyclic reaction pathway.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Andriani G. G. Chaidali, Ioannis N. N. Lykakis
Summary: A facile green synthetic protocol for the synthesis of several substituted N-(pyridin-2-yl)imidates was reported. The method involved the in situ formation of alpha-iminonitriles under the Lewis acid catalysis and subsequent conversion into the desired imidates using Cs2CO3 in alcoholic media. The synthetic protocol was also scalable and successfully applied for the synthesis of N-heterocycles.
Article
Chemistry, Multidisciplinary
Marina A. Tzani, Ioannis N. Lykakis
Summary: We investigated the efficient synthesis method of a series of trans-N,N-4,5-substituted-diaminocyclopent-2-enones (trans-DACPs) from furfural and anilines through Gold(III) chloride (HAuCl4) mediation. The protocol only required a low amount of catalysts (1.5 mol%), open air conditions, no additives, and short reaction times, resulting in good to high yields of the desired trans-DACPs. The method was also applicable to secondary amines, providing the corresponding 4,5-diamino-cyclopent-2-enones in good yields. To the best of our knowledge, this is the first gold-mediated paradigm as an efficient catalyst for the formation of the cyclopentenones core-bearing C-N bonds under mild reaction conditions.
CHEMISTRY-SWITZERLAND
(2023)
Review
Chemistry, Organic
Andriani G. Chaidali, Ioannis N. Lykakis
Summary: This review presents recent synthetic approaches and diverse applications of imidates, which are used as intermediates in organic transformations and have potential catalytic effects in the synthesis of N-heterocycles, natural products, and metal complexes. Various organic compounds, including nitriles, isocyanides, and amides, can be easily converted to imidates through simple and flexible processes. The review provides a categorized and summarized exploration of the recent synthetic routes and applications of imidates in organic transformations.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Michael G. Kallitsakis, Dimitra K. Gioftsidou, Marina A. Tzani, Panagiotis A. Angaridis, Michael A. Terzidis, Ioannis N. Lykakis
Summary: The newly developed photocatalyst [Cu(Xantphos)(neoc)]BF4 can effectively oxygenate cycloalkenes into allylic hydroperoxides or alcohols with high yields and chemoselectivity. This methodology has been successfully applied to the synthesis of various bioactive compounds and perfumery ingredients, showcasing fast and clean reaction processes.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
