4.7 Article

Isothermal detection of RNA with restriction endonucleases

Journal

CHEMICAL COMMUNICATIONS
Volume 47, Issue 1, Pages 200-202

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02208j

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Funding

  1. University of Maryland
  2. NSF [CHE0746446]

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Herein, we demonstrate how to detect nucleic acids that do not contain restriction endonuclease recognition sites with restriction endonucleases. We show that the topology of DNA probes used in this detection strategy remarkably affects the efficiency of RNA/DNA detection.

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