Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 6, Pages 1839-1841Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc02879g
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- Australian Research Council
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3-Chloro-Abu and 4-chloro-Nva are biosynthetically incorporated into E. coli peptidyl-Pro cis-trans isomerase B, as substitutes for Val and Leu, respectively. The extent of incorporation is up to similar to 90%, and substituted protein is catalytically active. By contrast, 4-chloro-Val is not an effective replacement for Ile.
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