Journal
CHEMICAL COMMUNICATIONS
Volume 47, Issue 48, Pages 12837-12839Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c1cc15829e
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Funding
- Danish Council for Independent Research
- Aarhus University
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An efficient synthesis of the macrolactone core of the rakicidins is described. The rakicidins are cytotoxic lipopeptides with interesting cancer cell selectivities including HIF-1-independent hypoxia-selective cytotoxicity and anti-invasive activity. Access to the core may now allow establishment of preliminary SAR and exploration of routes to several members of rakicidins.
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