Article
Chemistry, Organic
Mengzhu Guo, Fengying Dong, Xiangcong Yin, Lubin Xu, Liang Wang, Shuai-Shuai Li
Summary: In this study, medicinally significant 3-monosubstituted tetrahydroquinolines and 1,2-dihydroquinolines were controllably constructed via a redox-neutral vinylogous cascade condensation/[1,5]-hydride transfer/cyclization process in ethanol, showcasing novel features such as green solvent and metal-free conditions. Additionally, the electrophilicity and nucleophilicity of alpha,alpha-dicyanoalkenes were effectively utilized as hydride acceptors and gamma-exclusive nucleophiles.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Biochemistry & Molecular Biology
Agnes B. Petersen, Seyed Hossein Mirbarati, Birte Svensson, Jens O. Duus, David Teze
Summary: Engineering glycoside hydrolases is an important approach for obtaining catalysts that can form glycosidic bonds. In this study, an engineered enzyme called TtOGA-D120N from the GH84 family was shown to be an efficient O-, N-, and S-glycoligase, capable of using various nucleophiles. The enzyme also catalyzes the formation and release of an activated intermediate, which allows for cascade synthesis in combination with transglycosylases or glycosynthases, as demonstrated by the synthesis of a specific human milk oligosaccharide lacto-N-triose II.
Article
Biochemistry & Molecular Biology
Erol C. Vatansever, Kai S. Yang, Zhi Zachary Geng, Yuchen Qiao, Pingwei Li, Shiqing Xu, Wenshe Ray Liu
Summary: Researchers have designed a PylRS mutant, oClFRS, which efficiently catalyzes the genetic incorporation of o-substituted phenylalanines and have elucidated its structure and function. The binding of o-ClF in the active site of oClFRS involves two halogen bonds, which are crucial for its activity.
JOURNAL OF MOLECULAR BIOLOGY
(2022)
Article
Chemistry, Physical
Sannapaneni Janardan, A. S. Vijai Anand, Pothini Suman, Mohsin Y. Lone, Prakash C. Jha, C. V. S. Brahmmananda Rao, Akella Sivaramakrishna
Summary: This study demonstrates the metal-free reduction of pentavalent tetracoordinate phosphine oxides to trivalent phosphines using inexpensive hydrosilanes in the presence of various activators. The reactivity of silanes as reducing agents is influenced by the oxophilic/electrophilic nature of the silicon atom. The presence of a hydrazide precursor with CH(3)SiHCl(2) has proven to be more effective in the reduction of phosphine oxides.
Article
Chemistry, Physical
Hua Tan, Xuecheng Li, Hao Ma, Xiaolin Yang, Tong Zhan, Wenyu Xie, Suhua Wang, Jiaping Zhu
Summary: In this study, N-doped carbon embedded Ni catalysts were prepared and used for the transfer hydrogenolysis of lignin model compounds. The results showed that the catalysts prepared under specific pyrolysis conditions exhibited higher activity and selectivity, and the selectivity could be further improved after acid treatment. Moreover, the catalyst demonstrated good yields and stability for the conversion of various lignin model compounds.
SUSTAINABLE ENERGY & FUELS
(2022)
Article
Chemistry, Multidisciplinary
Michel Stephan, Max Voelker, Matthias Schreyer, Peter Burger
Summary: The synthesis of new neutral square-planar pyridine di-imine rhodium and iridium complexes, along with their crystal and electronic structures, are reported. The focus is on the non-innocence/innocence of the PDI ligand and the oxidation states of the metal centers. Experimental and theoretical methods were used to analyze the dp-pp interaction between the metal centers and the p-donor ligands, revealing the partial multiple-bond character of the M-O,S bonds.
CHEMISTRY-SWITZERLAND
(2023)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)