4.7 Article

Ultrasensitive nucleic acid detection using confocal laser scanning microscope with high crystalline silver dendrites

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 46, Pages 8818-8820

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc03280h

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Funding

  1. National Natural Science Foundation of China [20735003, 20890020]
  2. 973 Projects [2009CB930100, 2010CB933600]

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A new kind of silver micro-dendrites with no surfactants protected has been synthesized for the separation and detection of DNA merely by earth gravity as the density of silver is larger than that of water. Through this approach, the DNA of human T-lymphotropic virus type I (HTLV-I) can be detected down to 10 pM with the detection range from 10 pM to 100 nM.

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