4.7 Article

Salt concentration-induced dehybridisation of DNA-gold nanoparticle conjugate assemblies for diagnostic applications

Journal

CHEMICAL COMMUNICATIONS
Volume 46, Issue 34, Pages 6382-6384

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c0cc01488e

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Funding

  1. Ministry of Education, Science and Technology [2009-0089572]
  2. Seoul RBD Program [ST090795]

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We present the cooperative dehybridisation of DNA-gold nanoparticle conjugate (DNA-AuNP) assemblies induced by reduced salt concentration ([salt]), which can be precisely controlled by various conditions. The detection of Ag(+) based upon the [salt]-induced dehybridisation of DNA-AuNP assemblies is five times more sensitive than that achieved under conventional thermal melting conditions.

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