Article
Chemistry, Medicinal
Marta De Angelis, Barbara De Filippis, Marwa Balaha, Letizia Giampietro, Mariya Timotey Miteva, Giovanna De Chiara, Anna Teresa Palamara, Lucia Nencioni, Adriano Mollica
Summary: This study optimized the structure of resveratrol (RSV) by synthesizing new RSV derivatives and evaluated their potential anti-influenza virus activity. The results showed that nitro-containing compounds strongly inhibited viral replication. Furthermore, these derivatives exerted their antiviral effects by interfering with cellular mechanisms such as viral nuclear-cytoplasmic traffic.
Article
Biochemistry & Molecular Biology
Cagla Begum Apaydin, Merve Tansuyu, Zafer Cesur, Lieve Naesens, Fusun Goktas
Summary: A series of novel N-(3-oxo-1-thia-4-azaspiro[4.5]decan-4-yl)carboxamides have been synthesized and evaluated as antiviral agents. Some analogues showed activity against H3N2 influenza virus, with compounds 3c and 3d exhibiting the most potent antiviral effects. These findings contribute to the understanding of spirothiazolidinone-based inhibitors of influenza virus membrane fusion.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Abdalla E. A. Hassan, Hend. A. A. Hegazy, Islam Zaki, Marwa. H. H. Hassan, Medhat Ramadan, Abdelfattah. Z. Z. Haikal, Jia Sheng, Reham A. I. Abou-Elkhair
Summary: Novel antiviral drugs were synthesized and evaluated, showing specific activity against influenza virus. The study suggests that further optimization of this compound can provide potent antiviral agents.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Medicinal
Lin Tang, Haiyan Yan, Weibin Wu, Dawei Chen, Zhenxiong Gao, Jinqiang Hou, Cunlong Zhang, Yuyang Jiang
Summary: A series of novel substituted polycyclic pyridone derivatives were synthesized and found to exhibit potent anti-influenza activity, including inhibiting the replication of influenza A virus at picomolar concentrations. These compounds showed low cytotoxicity and promising potential as anti-influenza drug candidates.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Chanakan Winyakul, Weerachai Phutdhawong, Poomipat Tamdee, Jitnapa Sirirak, Thongchai Taechowisan, Waya S. Phutdhawong
Summary: Novel N-substituted 2,5-Diketopiperazine derivatives were synthesized and evaluated for their antiviral activities against influenza virus. Several derivatives showed negative results in inhibiting viral propagation, and molecular docking study revealed their strong interaction with key amino acid residues.
Article
Biochemistry & Molecular Biology
Irina Smirnova, Anastasiya Petrova, Gul'nara Giniyatullina, Anna Smirnova, Alexandrina Volobueva, Julia Pavlyukova, Vladimir Zarubaev, Tran Van Loc, Thao Tran Thi Phoung, Vu Thi Bich Hau, Nguyen Thi Thu Thuy, Myint Myint Khine, Oxana Kazakova
Summary: A series of sixteen A-ring modified oleanonic acid derivatives were synthesized and screened for antiviral activity against influenza and dengue viruses. Two compounds showed high potency against both viruses.
Article
Biochemistry & Molecular Biology
Hisashi Takada, Naoki Takizawa, Shouta Shibasaki, Hiroki Asaba, Masayuki Igarashi, Masakatsu Shibasaki, Yoshiaki Takahashi
Summary: Through screening, a C-nucleoside antibiotic formycin A with strong anti-influenza virus activity was discovered. The modification of the C-7 position of the pyrazolopyrimidine ring and the sugar moiety greatly affected the activity.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Masaki Shoji, Tomoyuki Esumi, Narue Tanaka, Misa Takeuchi, Saki Yamaji, Mihiro Watanabe, Etsuhisa Takahashi, Hiroshi Kido, Masayuki Yamamoto, Takashi Kuzuhara
Summary: Cyclobakucihols A, B, C, and D were found to inhibit influenza A viral infection and growth, decrease the expression of viral mRNAs and proteins in infected cells, and reduce the expression of host cell immune response genes. Cyclobakuchiols A, B, and C induced the Nrf2 activation pathway, demonstrating their anti-influenza viral activity involving host cell oxidative stress response.
Article
Biochemistry & Molecular Biology
Claudio Zippilli, Lorenzo Botta, Bruno Mattia Bizzarri, Lucia Nencioni, Marta De Angelis, Virginia Protto, Gianluca Giorgi, Maria Camilla Baratto, Rebecca Pogni, Raffaele Saladino
Summary: Novel belladine N-oxides active against influenza A virus were synthesized through a laccase-catalyzed oxidation reaction, showing high functional-group compatibility. These compounds exhibit inhibitory effects on the early stage of the virus replication life cycle.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Integrative & Complementary Medicine
Rongbo Luo, Chaoxiang Lv, Tiecheng Wang, Xiuwen Deng, Mingwei Sima, Jin Guo, Jing Qi, Weiyang Sun, Beilei Shen, Yuanguo Li, Donghui Yue, Yuwei Gao
Summary: Isoquercitrin shows significant anti-IAV and anti-IBV activity in vitro and in vivo, reducing virus replication and mortality in mouse lethal infection models. It also mitigates lung and multiple organ damage and blocks hyperproduction of cytokines induced by virus infection through inactivating NF-kappa B signaling. Intramuscular injection is a better drug delivery method for isoquercitrin.
Article
Chemistry, Multidisciplinary
Shuobin Liang, Xinyuan Ma, Man Li, Yanliang Yi, Qianqian Gao, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao
Summary: In this study, a series of heptavalent glycyrrhetinic acid derivatives based on beta-cyclodextrin scaffold were designed and synthesized using click chemistry. The synthesized compounds showed promising inhibitory activity against influenza virus infection, making them potential candidates for influenza entry inhibitors.
FRONTIERS IN CHEMISTRY
(2022)
Article
Immunology
Miao He, Zhihui Ren, Mohsan Ullah Goraya, Yinhong Lin, Jinghan Ye, Rui Li, Jianping Dai
Summary: Apigetrin, an active compound derived from Ixeris sonchifolia Hance, inhibits influenza A virus (IAV) infection by regulating TLR4 and autophagy signaling pathways. It reduces oxidative stress and cytokine storm induced by IAV.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Kai Ji, Guo-Ning Zhang, Jian-Yuan Zhao, Mei Zhu, Ming-Hua Wang, Ju-Xian Wang, Shan Cen, Yu-Cheng Wang, Wen-Yan Li
Summary: In this study, we designed and synthesized 18 substituted indole derivatives containing a triazole scaffold as novel anti-influenza A virus candidates using a bio-isosteric and scaffold-hopping strategy. Compound 7a showed the most potent anti-IAV activity and low cytotoxicity, with a high selectivity index.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Review
Biochemistry & Molecular Biology
Mariangela Agamennone, Marialuigia Fantacuzzi, Giovanni Vivenzio, Maria Carmina Scala, Pietro Campiglia, Fabiana Superti, Marina Sala
Summary: Influenza viruses are a major cause of high morbidity and mortality worldwide. Current approaches for fighting flu include seasonal vaccines and antiviral drugs, but they have limitations. Due to the highly mutative nature of influenza viruses, there is an urgent need for the development of new antiviral therapies, and peptide-based therapies show great promise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Qili Lu, Dipesh S. Harmalkar, Guofeng Quan, Haeun Kwon, Jungsook Cho, Yongseok Choi, Dongho Lee, Kyeong Lee
Summary: The study presents the total synthesis of the neuroprotective compound cudraisoflavone J from Cudrania tricuspidata, isolating two enantiomers using kinetic resolution. The absolute configuration of naturally occurring cudraisoflavone J was elucidated using a modified Mosher's method.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Multidisciplinary
Nagarathanam Yeerasamy, Ankan Ghosh, Jinming Li, Kazuhiro Watanabe, Jeffrey D. Serrill, Jane E. Ishmael, Kerry L. McPhail, Rich G. Carter
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Chemistry, Organic
Kazuhiro Watanabe, Jinming Li, Nagarathanam Veerasamy, Ankan Ghosh, Rich G. Carter
Article
Chemistry, Organic
Junji Sakurai, Takuya Kikuchi, Ohgi Takahashi, Kazuhiro Watanabe, Tadashi Katoh
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2011)
Article
Chemistry, Organic
Kazuhiro Watanabe, Hiroaki Shibata, Yu Imai, Tadashi Katoh
Article
Chemistry, Organic
Kazuhiro Watanabe, Tomohiro Sugizaki, Yumi Tozawa, Tadashi Katoh
Article
Polymer Science
Kazuhiro Watanabe, Kyoko Sugiyama, Sachiko Komatsu, Kentaro Yoshida, Tetsuya Ono, Tsutomu Fujimura, Yoshitomo Kashiwagi, Katsuhiko Sato
Article
Chemistry, Medicinal
Koichi Narita, Ryuhei Kimura, Hiroka Satoh, Kazuhiro Watanabe, Yuichi Yoshimura
Summary: The research achieved the concise syntheses of two alkylated hydroquinone natural products using a protecting-group-free method, employing alkenylboronic acid as a key reagent and reporting the synthesis of violaceoid C for the first time.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Electrochemistry
Sachiko Komatsu, Yusuke Sasano, Kyoko Sugiyama, Kazuhiro Watanabe, Masayuki Kumano, Kentaro Yoshida, Tetsuya Ono, Yoshiharu Iwabuchi, Tsutomu Fujimura, Katsuhiko Sato, Yoshitomo Kashiwagi
Summary: This study evaluated the catalytic activity of nitroxyl radicals in oxidizing alcohols, comparing the reactivity of different types of nitroxyl radicals.
INTERNATIONAL JOURNAL OF ELECTROCHEMICAL SCIENCE
(2021)
Article
Chemistry, Analytical
Ken-ichi Ohno, Katsuhiko Sato, Masayuki Kumano, Kazuhiro Watanabe, Tsutomu Fujimura
Summary: A novel method for electrochemical detection using sesamol was proposed in this paper, which was successfully applied to measure NO and OH radicals, demonstrating simplicity, sensitivity, and selectivity.
ANALYTICAL SCIENCES
(2021)
Article
Chemistry, Analytical
Kyoko Sugiyama, Kazuhiro Watanabe, Sachiko Komatsu, Kentaro Yoshida, Tetsuya Ono, Tsutomu Fujimura, Yoshitomo Kashiwagi, Katsuhiko Sato
Summary: A modified electrode was developed by immobilizing poly(azure A) on a glassy carbon electrode through electropolymerization, exhibiting redox response during CV and DPV. The redox reaction followed the Nernst equation and the peak potential shifted according to solution pH. The electrode, useful as a pH sensor, showed more distinct shifts in oxidation potential using DPV and could be repetitively used over 50 times in the pH range of 1 to 10.
ANALYTICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Koichi Narita, Keisuke Suganuma, Toshihiro Murata, Ryutaro Kondo, Hiroka Satoh, Kazuhiro Watanabe, Kenroh Sasaki, Noboru Inoue, Yuichi Yoshimura
Summary: Research on the synthesized 2,5-diphenyloxazole analogs showed that they exhibited trypanocidal activity against various trypanosome species, with some derivatives showing strong resistance against T. congolense, but also leading to cytotoxicity in cells.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Koichi Narita, Shotaro Yoshida, Hiroka Satoh, Kazuhiro Watanabe, Yuichi Yoshimura
Summary: In this study, the optically active form of the hexahydrobenzofurobenzopyran ring, found in naturally occurring bisabosquals, was synthesized for the first time. The synthetic route involved three key steps: induction of chirality, transfer of chirality, and stepwise construction of the hexahydrobenzofurobenzopyran skeleton. Both the racemic and optically active hexahydrobenzofurobenzopyrans were obtained using this synthetic route.
Article
Chemistry, Medicinal
Katsuhiko Sato, Kazuhiro Watanabe, Kyoko Sugiyama, Sachiko Komatsu, Tsutomu Fujimura
Summary: In this study, it was reported that p-acetamidophenylboronic acid can electrolytically cleave the carbon-boron bond to p-acetamidophenol under neutral pH conditions, which may be useful for the development of electrical controlled drug delivery systems.
CHEMICAL & PHARMACEUTICAL BULLETIN
(2021)
Meeting Abstract
Chemistry, Multidisciplinary
Nagarathanam Veerasamy, Kazuhiro Watanabe, Rich G. Carter
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Meeting Abstract
Chemistry, Multidisciplinary
Kazuhiro Watanabe, Nagarathanam Veerasamy, Rich G. Carter
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2014)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
