Article
Chemistry, Multidisciplinary
Sajena Kanangat Saraswathi, Varsha Karunakaran, Kaustabh Kumar Maiti, Joshy Joseph
Summary: The study reports the synergistic self-assembly of two viologen-functionalized TPE molecules with CT-DNA, leading to DNA condensation through electrostatic and groove binding interactions, and confirms the DNA condensation abilities. Increasing the concentration of TPE-V results in the transformation of the TPE-V/CT-DNA complex from beads-on-a-string assembly to completely condensed structures.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Arlin Rodriguez, Dhanush Gandavadi, Johnsi Mathivanan, Tingjie Song, Bharath Raj Madhanagopal, Hannah Talbot, Jia Sheng, Xing Wang, Arun Richard Chandrasekaran
Summary: The programmable nature of DNA allows the construction of custom-designed static and dynamic nanostructures. However, the high concentrations of magnesium ions required for assembly restrict their applications. In this study, we investigate the assembly of DNA nanostructures in various ions and successfully assemble a majority of these structures in Ca2+, Ba2+, Na+, K+ and Li+. We also find that structures assembled in monovalent ions exhibit significantly higher nuclease resistance compared to those assembled in divalent ions.
Article
Chemistry, Multidisciplinary
Yuxiang Dong, Jiliang Liu, Xuanzhao Lu, Jialin Duan, Liqi Zhou, Lizhi Dai, Min Ji, Ningning Ma, Yong Wang, Peng Wang, Jun-Jie Zhu, Qianhao Min, Oleg Gang, Ye Tian
Summary: Self-assembly processes are important for fabricating complexly organized nanomaterials, but often limited in creating structures with multiscale order. In this study, a two-stage assembly strategy is introduced to successfully form complexly organized nanoparticle crystals.
Article
Chemistry, Multidisciplinary
Jiajia Zou, Ashley C. Stammers, Andrea Taladriz-Sender, Jamie M. Withers, Iain Christie, Marina Santana Vega, Badri L. Aekbote, William J. Peveler, David A. Rusling, Glenn A. Burley, Alasdair W. Clark
Summary: An orthogonal, noncovalent approach is presented for the assembly of higher-order DNA origami nanostructures. By incorporating perfluorinated tags into DNA origami tiles, their hierarchical assembly is controlled via fluorous-directed recognition. This integrated catch-and-latch approach combining fluorous effect with base-pairing specificity enables increased assembly efficiency and requires fewer DNA sequences, providing a cheap and efficient means for producing discrete superstructures in DNA nanotechnology.
Review
Biochemistry & Molecular Biology
Shuang Wang, Xiaolin Xie, Zhi Chen, Ningning Ma, Xue Zhang, Kai Li, Chao Teng, Yonggang Ke, Ye Tian
Summary: The DNA-grafted nanoparticle serves as a programmable atom equivalent for assembling three-dimensional superlattice with novel properties, allowing for the exploration of assembly strategies and mechanisms, as well as future applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Multidisciplinary
Nada Farag, Gianfranco Ercolani, Erica Del Grosso, Francesco Ricci
Summary: In this study, we demonstrate the use of DNA repair enzymes to control the assembly of DNA-based structures. By designing responsive nucleic acid modules and utilizing specific enzyme repair activity, we were able to achieve the self-assembly of DNA tiles into tubular structures. This approach is programmable, specific, and orthogonal, allowing for accurate prediction of tile distribution. Additionally, we show that BER-enzyme inhibitors can be used to control DNA-tile assembly in a specific and concentration-dependent manner.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Plant Sciences
John W. Mishler-Elmore, Yadi Zhou, Abhijit Sukul, Mercedes Oblak, Li Tan, Ahmed Faik, Michael A. Held
Summary: This review discusses the mechanisms and regulation of assembly of the extensin (EXT) network, including the secretion of EXT monomers and crosslinking processes, as well as the functions of non-crosslinking EXTs and the regulation of crosslinking status. It also explores the potential regulatory mechanism for controlling covalent crosslinking in response to injury and pathogen infection, and its relationship to the subcellular localization of crosslinking enzymes.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Alexander Hensley, William M. Jacobs, W. Benjamin Rogers
Summary: DNA-coated colloids can self-assemble into various crystal structures, and we have used microfluidics to quantify the kinetics of crystallization. Our study shows that classical theories can accurately predict nucleation and growth rates, and we have successfully designed large single crystals with specific structural coloration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Multidisciplinary
Jue Yin, Mo Xie, Junke Wang, Meirong Cui, Dan Zhu, Shao Su, Chunhai Fan, Jie Chao, Qian Li, Lianhui Wang
Summary: In this work, the authors report a simple and versatile one-pot strategy to fabricate DNA architectures with the assistance of spherical gold nanoparticles modified with thiolated oligonucleotide strands. The desired architectures are formed via the stochastic co-assembly of different modules.
Article
Chemistry, Multidisciplinary
Katarina Gvozden, Sanja Novak Ratajczak, Alberto G. Orellana, Emmanuel Kentzinger, Ulrich Rucker, Jan K. G. Dhont, Cristiano De Michele, Emmanuel Stiakakis
Summary: Stiff DNA fragments can self-assemble into various smectic mesophases in concentrated aqueous solutions by selectively screening blunt-end DNA stacking interactions. The strength of attractions can be controlled to stabilize different phases, demonstrating the potential for precise tuning of DNA blunt-ends as monovalent attractive patches in the assembly of nonconventional DNA-based liquid crystal phases.
Article
Multidisciplinary Sciences
Daichi Hayakawa, Thomas E. Videbaek, Douglas M. Hall, Huang Fang, Christian Sigl, Elija Feigl, Hendrik Dietz, Seth Fraden, Michael F. Hagan, Gregory M. Grason, W. Benjamin Rogers
Summary: This article explores new design principles for making self-limiting architectures using self-assembly. The authors use DNA origami to create triangular subunits with specific interactions and binding angles, and study their assembly into tubules with a self-limited width. They demonstrate that the tubules can reach significant lengths and that their width can be controlled through geometric programming. They also find that the width and chirality of the tubules can be manipulated by increasing the number of subunit species. These findings provide insights into the role of assembly complexity and geometry in self-limiting assembly and have potential applications in other self-limiting architectures.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Engineering, Biomedical
Jinpeng Han, Yuchen Cui, Zi Gu, Dayong Yang
Summary: The study developed a nanocarrier system that can efficiently release drugs in cells while minimizing side effects, utilizing polyphenol-DNA nanocomplexes. Through programmable assembly and disassembly processes, this method achieves precise release of multiple genes and drugs in cells.
Review
Chemistry, Multidisciplinary
Jason S. Kahn, Oleg Gang
Summary: Nanoparticles with unique properties have a wide range of potential applications, and DNA nanotechnology allows for programmable assembly to control particle organization in 1D, 2D, and 3D structures, enabling the creation of designer nanomaterials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Joshua A. Johnson, Vasiliki Kolliopoulos, Carlos E. Castro
Summary: Simultaneous self-assembly of two distinct DNA origami nanostructures folded with the same scaffold strand was achieved in a single pot by adjusting concentrations of competing strands. The relative yields were correlated well with folding kinetics of individual structures, facilitating efficient fabrication of multi-structure systems and materials.
CHEMICAL COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Anjali Bindu Ramesan, Sandeepa Kulala Vittala, Joshy Joseph
Summary: This study reports a novel approach utilizing non-covalent interactions for mutually assisted assembly of a fullerene derivative and DNA structures, resulting in ordered fullerene-DNA nanosheets. Different lengths of DNA and oligonucleotides show varying degrees of crystallinity and ordered arrangements when interacting with fullerene. Furthermore, a cyanine modified DNA demonstrated addressable assembly with efficient fluorescence quenching.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)