Article
Chemistry, Multidisciplinary
Nitesh K. Nandwana, Bhawani, Vikki N. Shinde, Anil Kumar
Summary: A highly efficient copper-catalyzed three component, one-pot reaction has been developed for the synthesis of imidazo[1,2-c]quinazolines and benzimidazo[1,2-c]quinazolines. The reaction shows good tolerance to various functional groups and yields the desired products in moderate to good yields.
Article
Chemistry, Multidisciplinary
Prahallad Meher, Raj Kumar Samanta, Sourav Manna, Sandip Murarka
Summary: This study describes a photoredox-catalyzed arylative radical cascade reaction involving N-acryloyl-2-arylbenzoimidazoles and diaryliodonium triflates, leading to the formation of a diverse range of pharmaceutically important arylated-benzimidazo[2,1-a]isoquinolin-6(5H)-ones. Importantly, the synthesized benzimidazoisoquinolinones are easily manipulated for further synthesis, allowing efficient access to benzimidazole-fused polycyclic heterocycles.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Hai-Ling Wang, Qiu-Xiang Yu, Zhong-Hong Zhu, Xing-Lin Lu, Yun-Lan Li, Fu-Pei Liang, Hua-Hong Zou
Summary: We successfully achieved multiple condensation of o-vanillin derivatives using a rare earth metal catalyst and a one-pot in situ tandem reaction under mild solvothermal conditions, obtaining complex dimers and trimers with distinct single-molecule magnetic behaviors. This is the first realization of multiple acetal reactions catalyzed by coordination-directed catalysis under one-pot conditions, providing a new approach for the development of fast, facile, green, and efficient synthetic methods for complex compounds.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Jing Liu, Hong-Li Huang, Chen Wang, Yinghua Li, Huaqiang Li, Honggang Hu, Shipeng He, Hua Tang, Fei Gao
Summary: A visible-light-driven cascade radical cyclization process has been established for the synthesis of alpha-carbonyl alkyl-substituted benzimidazo[2,1-alpha]isoquinolin-6(5H)-ones. This protocol offers an efficient and practical method with outstanding yields, mild reaction conditions, and excellent functional group tolerance.
Article
Chemistry, Organic
Tengda Si, Hun Young Kim, Kyungsoo Oh
Summary: The nitroso group acts as a traceless directing group in C-H functionalization and is ultimately removed after the reaction. The ability of o-NQ catalysts to oxidize N-alkylanilines without solvents and stoichiometric amounts of oxidants provides a new opportunity for developing telescoped catalyst systems without the need to handle hazardous N-nitroso compounds.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Juntao Yang, Bingxian Liu, Junbiao Chang
Summary: A ruthenium(II)-catalyzed one-pot synthesis of highly substituted 1,2-dihydropyridines (DHPs) via a three component reaction system has been successfully developed. The reaction utilizes a simple Ru(II) catalyst without the need for specific ligands. The catalytic system shows excellent functional group compatibility with a wide range of starting materials. The obtained DHPs can be easily converted into tetrahydropyridines and azabicyclo[4.2.0]octa-4,7-dienes by subsequent reduction or [2 + 2] cycloaddition reaction.
Article
Chemistry, Applied
Alexis Truchon, Aurelien Dupeux, Sandra Olivero, Veronique Michelet
Summary: A gold-catalyzed orthogonal tandem reaction using HFIP as a Lewis acid has been developed to access carbocyclic ketone on naphthalene substrates. The yield of cyclic ketones ranged from 15% to 91% using a variety of acenaphthylene carbaldehydes. The mechanism involved a cyclization process followed by an [Au]-HFIP interaction for the final rearrangement. The gram-scale transformation and post-functionalization bromination were successfully carried out.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Multidisciplinary
Arindam Khatua, Pranay Shyamal, Souvik Pal, Ayan Mondal, Alakesh Bisai
Summary: A new synthesis method has been developed for the preparation of enantioenriched compounds with all-carbon quaternary stereogenic centers. The method has been successfully applied in the total synthesis of several important alkaloids.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Venkata Chandrasekhar Kommuri, Ajesh Vijayan, Lokesh Pawar, Athimoolam Arunachalampillai
Summary: A facile and effectual one-pot synthesis protocol has been developed for the construction of pyrido[1,2-a]benzimidazole and its derivatives. The reaction conditions were optimized to achieve good yields of novel functionalized regioselective benzimidazole compounds.
Article
Chemistry, Applied
Zhen Yao, Ji Yang, Zhenli Luo, Jianhan Ye, Jiahong Han, Xin Zhang, Lijin Xu, Peng Wang, Qian Shi
Summary: This study presents a tandem one-pot regioselective synthesis method under visible-light photocatalysis, providing a straightforward approach for the synthesis of C4-difluoroalkylated phthalazin-1(2H)-ones with broad substrate scope and wide functional group tolerance.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Physical
Fengqian Zhao, Jian-Xing Xu, Fu-Peng Wu, Xiao-Feng Wu
Summary: This communication describes a copper-catalyzed selectivity-reversed borocarbonylation. In the presence of CuOAc/BuPAd2 catalytic system, a series of unactivated terminal alkenes were transformed into β-boryl ketones in moderate yields, using sterically hindered alkyl bromides as the electrophiles.
JOURNAL OF CATALYSIS
(2023)
Article
Chemistry, Organic
Jorge Saavedra-Olavarria, Patricio Hermosilla-Ibanez, Iriux Almodovar, Edwin G. Perez
Summary: A strategy for synthesizing vinyl sulfones and beta-chlorosulfones under fast-heating conditions using inexpensive reagents and a catalytic system has been reported. The reaction involves atom transfer radical addition (ATRA) and E2 elimination, allowing for the quick and easy generation of a wide range of vinyl sulfones and beta-chlorosulfones.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Estefania Capel, Javier Luis-Barrera, Ana Sorazu, Uxue Uria, Liher Prieto, Efraim Reyes, Luisa Carrillo, Jose L. Vicario
Summary: A transannular approach has been developed for the construction of pyrrolo[1,2-b]isoquinolinones starting from benzofused nine-membered enelactams. The reaction has a wide scope and can produce a variety of tricyclic products in good overall yield regardless of the substitution pattern in the initial lactam substrate. Furthermore, this method can be used for the total synthesis of certain biologically active compounds.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Jiangjie Zhang, Jun Ying, Xiao-Feng Wu
Summary: A novel palladium-catalyzed tandem cyclization and carbonylation reaction was developed for the synthesis of indeno[1,2-b]indol-10(5H)-one derivatives. The reaction proceeded smoothly with high yields using formic acid as the CO source. This method can also be applied for the modification of various bioactive molecules.
JOURNAL OF CATALYSIS
(2023)
Article
Chemistry, Physical
Yong Tang, Ciduo Wang, Hanqing Xie, Yuelin Xu, Chunyu Wang, Chuang Du, Zhi Wang, Lei Wang
Summary: A lipase-catalyzed method was developed for the synthesis of spirooxindole frameworks, achieving moderate to good yields and excellent functional group tolerance. The reaction mechanism was also speculated in this study.
Article
Nanoscience & Nanotechnology
Shuai Wu, Feng He, Guoxin Xie, Zhengliang Bian, Yilong Ren, Xinyuan Liu, Haijun Yang, Dan Guo, Lin Zhang, Shizhu Wen, Jianbin Luo
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Multidisciplinary
Youshan Li, Zhenbang Lou, Hongyun Li, Haijun Yang, Yufen Zhao, Hua Fu
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2020)
Article
Engineering, Environmental
Ouchen Cai, Yuanxiao Xiong, Haijun Yang, Jinyong Liu, Hui Wang
FRONTIERS OF ENVIRONMENTAL SCIENCE & ENGINEERING
(2020)
Article
Chemistry, Organic
Ningning Man, Zhenbang Lou, Yuming Li, Haijun Yang, Yufen Zhao, Hua Fu
Article
Chemistry, Multidisciplinary
Ningning Man, Yuming Li, Jiyang Jie, Hongyun Li, Haijun Yang, Yufen Zhao, Hua Fu
Summary: The chiral phosphoric acid-catalyzed couplings of C-alkynyl N,N'-di-(tert-butoxycarbonyl)-aminals with beta-naphthols produced chiral propargylamines with moderate to high yields and high to excellent enantioselectivity. Sequential chiral phosphoric acid-catalyzed formation of N-(tert-butoxycarbonyl)-imines and 1,2-addition of beta-naphthols to the N-Boc-imines were key steps in the reactions. Additionally, chiral 1,2-dihydronaphtho[2,1-b]furans and naphtho[2,1-b]furans were successfully prepared by further adding AgOAc and 2,6-lutidine or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) to the resulting chiral propargylamines solution.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Organic
Yuming Li, Jiyang Jie, Hongyun Li, Haijun Yang, Hua Fu
Summary: A novel palladium-catalyzed [4 + 1] cycloaddition reaction has been developed for the synthesis of spirotetrahydrofuran oxindoles. This method utilizes diphenyl 2-oxoindolin-3-yl phosphates and 2-methylidenetrimethylene carbonate as reactants to provide the desired compounds in good to excellent yields at room temperature, offering a new strategy for the construction of spirooxindole derivatives with unique three-dimensional structures.
Article
Chemistry, Multidisciplinary
Huaqiang Cao, Cheng Wang, Baojun Li, Tianyu Chen, Peng Han, Yan Zhang, Haijun Yang, Qunyang Li, Anthony K. Cheetham
Summary: This study reports a method for synthesizing graphene by reacting hexabromobenzene with Na metal followed by annealing. The obtained graphene has predominately few-layer and single-layer structures and exhibits exciting properties and potential applications. Additionally, the method also demonstrates high catalytic activity and electronic conductivity.
Article
Chemistry, Multidisciplinary
Zhifang Liu, Huaipeng Wang, Huaqiang Cao, Dan Xie, Chun Li, Haijun Yang, Wenqing Yao, Anthony K. Cheetham
Summary: Intercalation of ions significantly enhances the mechanical properties of black phosphorus, leading to the generation of high-strength phosphorene films, which demonstrate the potential for practical applications of black phosphorus devices.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yulan Tian, Huaqiang Cao, Haijun Yang, Wenqing Yao, Jiaou Wang, Zirui Qiao, Anthony K. Cheetham
Summary: In this study, kinetic studies were conducted on spin catalysis reactions using electron spin resonance spectroscopy. Graphene belts synthesized by radical coupling method were used as catalysts. The results showed that sigma-type free radical species played a dominant role in the catalytic activity through spin-spin interaction. The spin catalysis mechanism was found to be applicable in both the oxygen reduction reaction and organic synthesis. The graphene belt spin catalyst demonstrated excellent performance with high ORR half-wave potential and long-term stability, as well as high conversion and yield in benzylamine coupling with molecular oxygen to generate imine.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Can Liu, Xianjin Zhu, Yong Liu, Haijun Yang, Hua Fu
Summary: Achieving site-selectivity and chemoselectivity is challenging for substrates with multi-reactive sites in organic reactions. In this study, four different reactions were explored using model substrates with six reactive sites. By varying the reaction conditions, different bases were found to control the site-selectivity and chemoselectivity of the reactions. This strategy of "one substrate - multiple reactions - multiple products" reduces cost, increases product diversity, and provides more opportunities for pharmaceutical screening.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Yuming Li, Jiyang Jie, Weixin Xiao, Haijun Yang, Hua Fu
Summary: A palladium-catalyzed [3 + 3] annulation reaction was developed for the synthesis of pyrido[2,3-b]indole derivatives. The convenient and practical method provides diverse derivatives for the screening of biological and pharmacological molecules.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Multidisciplinary
Xi Yuan, Xudong Wu, Fei Peng, Haijun Yang, Changjin Zhu, Hua Fu
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Xianjin Zhu, Can Liu, Yong Liu, Haijun Yang, Hua Fu
CHEMICAL COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Xianjin Zhu, Yong Liu, Can Liu, Haijun Yang, Hua Fu
Article
Chemistry, Organic
Fei Peng, Hua Tian, Pengxiang Zhang, Haijun Yang, Hua Fu
ORGANIC & BIOMOLECULAR CHEMISTRY
(2019)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)
