4.7 Article

Synthesis and preliminary biological evaluations of [F-18]-1-deoxy-1-fluoro-scyllo-inositol

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 37, Pages 5527-5529

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b913317h

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A novel PET radiotracer, [F-18]-1-deoxy-1-fluoro-scyllo-inositol, was synthesized via a one-pot reaction in 16 +/- 3% uncorrected radiochemical yield within 80 minutes; although this compound revealed low brain penetration it shows promise in rodent tumour models for breast cancer imaging.

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