4.7 Article

Combining two-directional synthesis and tandem reactions: new access to 3,5-disubstituted pyrrolizidines and first total synthesis of alkaloid cis-223B

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 16, Pages 2207-2209

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b900451c

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Funding

  1. EPSRC [EP/E055346]
  2. Engineering and Physical Sciences Research Council [EP/E055346/2] Funding Source: researchfish
  3. EPSRC [EP/E055346/2] Funding Source: UKRI

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Two new tandem reactions for the synthesis of 3,5-disubstituted pyrrolizidines and the first total synthesis of alkaloid cis-223B (in 7 steps and 43% overall yield), involving a double cross metathesis and double Michael addition as key steps, are presented.

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