4.7 Article

Copper-catalyzed three-component coupling of arynes, terminal alkynes and activated alkenes

Journal

CHEMICAL COMMUNICATIONS
Volume -, Issue 40, Pages 5013-5015

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/b809409h

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Funding

  1. National Science Council of Republic of China [NSC-96-2113-M-007-020-MY3]

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The three-component coupling of benzynes with terminal alkynes and activated alkenes in the presence of CuI, PCy3 and CsF in a 1 : 1 mixture of CH3CN and THF at 50 degrees C for 5 h gave 1-alkyl-2-alkynylbenzenes in good to moderate yields.

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