Article
Chemistry, Multidisciplinary
Diana Silva-Brenes, Noemie Emmanuel, Vilmali Lopez Mejias, Jorge Duconge, Cornelis Vlaar, Torsten Stelzer, Jean-Christophe M. Monbaliu
Summary: This study demonstrates an improved synthesis method of Modafinil in a continuous flow reactor, achieving higher yield and purity with harmless by-products. The method also contributes to the development of an end-to-end pharmaceutical manufacturing system.
Article
Chemistry, Organic
Yuyan Zhao, Xu Jiang, Shihuan Zhou, Jin Tian, Piao Yang, Yanli Chen, Quan Zhang, Xianlin Xu, Yongzheng Chen, Jiawei Yang
Summary: In this study, a highly enantioselective and broad substrate scope methionine sulfoxide reductase B (MsrB) homologue, named liMsrB, was identified from Limnohabitans sp. 103DPR2. It showed good activity and enantioselectivity towards various sulfoxides. Chiral sulfoxides in the S configuration were efficiently prepared through kinetic resolution, with yields of approximately 50% and enantiomeric excess of 92-99% at a high initial substrate concentration of up to 90 mM (11.2 g L-1).
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Chemistry, Organic
Cheng-yi Chen, Zhichao Lu, Thomas Scattolin, Chengsheng Chen, Yonghong Gan, Mark McLaughlin
Summary: A concise, transition-metal and protection-free synthesis of adagrasib (MRTX849), a novel KRASG12C inhibitor drug, was achieved using two sequential SNAr reactions to introduce chiral building blocks to the tetrahydropyridopyrimidine core. Extensive reaction optimization led to a robust, transition-metal-free oxidation of the sulfide intermediate. The use of a suitable leaving group at the 4-OH position facilitated a facile SNAr displacement to introduce the chiral piperazine, resulting in a five-step, chromatography-free synthesis with improved efficiency.
Article
Chemistry, Multidisciplinary
Palasetty Chandu, Sourabh Biswas, Sumit Garai, Devarajulu Sureshkumar
Summary: In this study, we present an efficient method for the synthesis of poly-substituted sulfonated cyclopropane derivatives using sodium sulfinates. The method shows broad applicability, scalability, and compatibility with late-stage functionalization, with good tolerance towards diverse functional groups.
Article
Chemistry, Inorganic & Nuclear
Abdallah M. Elgorban, Najat Marraiki, Siddique Akber Ansari, Asad Syed
Summary: In this study, copper nanoparticles immobilized on magnetic Fe3O4 nanoparticles using Calendula extract as a reducing and stabilizing agent were successfully synthesized as a green catalyst for the efficient oxidation of organic sulfides to sulfoxides. The material exhibited superparamagnetic properties, allowing for easy magnetic separation and reuse for multiple cycles.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Jin Kyu Park, Sunwoo Lee
Summary: The oxidation of diaryl sulfides and aryl alkyl sulfides to sulfoxides and sulfones under electrochemical conditions was studied. Sulfoxides were selectively obtained in DMF with a constant current of 5 mA for 10 hours, while sulfones were the major products in MeOH with a constant current of 10 or 20 mA for 10 hours. The oxygen in both sulfoxides and sulfones is derived from water.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Rene Doeren, Jens Hartmann, Benjamin Leibauer, Martin Panthoefer, Mihail Mondeshki, Wolfgang Tremel
Summary: Selective oxidation of thioethers is an important reaction, and the use of reduced Magneli-type tungsten oxide WO3-x as a catalyst can efficiently achieve the oxidation of thioethers to sulfoxides with high selectivity. The WO3-x nanocatalysts exhibit excellent stability and recyclability, making them a robust redox-nanocatalyst for a wide range of applications.
DALTON TRANSACTIONS
(2021)
Article
Polymer Science
Paul Morandi, Yohann Catel, Jorg Angermann, Pascal Fassler, Jean-Jacques Robin, Sophie Monge
Summary: In this study, novel polymer materials containing a new oxidizing agent were synthesized for the formulation of odorless self-cure and dual-cure dental materials.
Article
Chemistry, Multidisciplinary
Xu Zhang, Rui Zhou, Zhengyuan Qi, Liping Chen, Lei Yu
Summary: Selective oxidation of sulphides to produce sulfoxides or sulphones is a key technique in industry. In this paper, it was found that the reaction could be catalyzed by a PhSe(O)OH/Al(NO3)(3) system in ethanol using H2O2 as the oxidant. The selectivity of the reaction could be controlled by adjusting the amount of H2O2, offering a potentially applicable method for large scale productions. The synergistic effect of Se, Al3+ and nitrate played a crucial role in the reaction.
REACTION CHEMISTRY & ENGINEERING
(2022)
Article
Chemistry, Multidisciplinary
Pawan Kumar, Anuradha Vijay Jagtap, Sharad Gupta, Chathakudath P. Vinod
Summary: In this study, an efficient La2CuO4 perovskite catalyst was used for one-step oxidation of benzene to phenol under mild conditions, showing high efficiency and selectivity. The adjustment of reaction conditions was crucial for optimizing selectivity of the product.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Physical
Indah Raya, Usama S. Altimari, Baraa G. Alami, Seelam Srikanth, M. Abdulfadhil Gatea, Rosario Mireya Romero-Parra, Luis Andres Barboza-Arenas, Yasser Fakri Mustafa
Summary: This paper presents a highly effective approach to producing derivatives of aromatic sulfoxides. The method uses environmentally friendly reaction conditions and improves synthesis efficiency. The unique utilization of sodium bromide (NaBr) reagent allows for the electro-oxidation of sulphides to sulfones, successfully transforming sulfoxides from sulphides to biologically relevant substrates. With electricity as the terminal oxidant, this environmentally friendly sulfoxidation strategy demonstrates high efficiency, excellent functional group compatibility, a broad substrate scope, and mild conditions for producing sulfoxides in moderate to excellent yields.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Organic
Xiaobo Xu, Leyu Yan, Shengqiang Wang, Panpan Wang, A-Xiu Yang, Xiaolong Li, Hao Lu, Zhong-Yan Cao
Summary: A practical and mild method for the switchable synthesis of sulfoxides or sulfones via selective oxidation of sulfides using cheap NFSI as the oxidant has been developed. These transformations were achieved by varying the NFSI loading with H2O as the green solvent and oxygen source without any additives, showcasing good functional group tolerance.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Organic
Arash Ghorbani-Choghamarani, Zahra Taherinia
Summary: This article discusses the application of greener methods in the synthesis of sulfoxides and the study on sulfinylation reaction methods. Various compounds have been synthesized through different pathways, providing new insights into the preparation of sulfoxides.
Article
Chemistry, Multidisciplinary
Bo Wu, Min Huang, Xing Yu, Jin Liu, Tiejun Lin, Liangshu Zhong
Summary: Selective oxidation of methane to oxygenates using low-cost and environment-friendly molecular oxygen (O-2) under mild reaction conditions is a promising strategy but still remains a grand challenge. In this concept, the recent progresses for selective oxidation of methane to oxygenates using O-2 based on tandem catalysis by coupling with in situ generation of hydrogen peroxide were summarized. The remaining challenges and future perspectives for selective oxidation of methane to oxygenates via tandem catalysis were also proposed.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Hu Zhang, Shengnan Yue, Xiujing Zou, Xueguang Wang, Xingli Zou, Xionggang Lu
Summary: A titanium dioxide-supported chromium oxide catalyst (CrOx/TiO2) was developed for the first time to achieve complete conversion of HAIBN with a high yield of AIBN (94.8%) using hydrogen peroxide as the oxidant.
CHEMICAL COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)