Article
Chemistry, Multidisciplinary
Yan Zhang, Fanglin Gong, Yue Wu, Siyuan Hou, Lingjing Xue, Zhigui Su, Can Zhang
Summary: The study utilized poly-beta-cyclodextrin and dextran sulfate grafted with benzimidazole to self-assemble into a supramolecular nanoassembly to address cholesterol crystals in lysosomes. The nanoassembly can release cholesterol crystals in lysosomes, promoting cholesterol efflux and aiding in the regression of atherosclerosis.
Article
Chemistry, Applied
Hidenori Ochiai, Shunichi Kubota, Miwa Sasagawa, Taiki Mihara, Atsuhiro Yamashita, Tomohide Nakamata, Akira Nishiyama
Summary: The stereoinvertive deoxyamination involving Bose-Mitsunobuazidation and the Staudinger reaction was utilized for the synthesis of edoxaban under mild conditions in the presence of a neighboring group. The one-pot process enabled the access to key intermediates without isolating azide intermediates. Furthermore, changing the substituent on the neighboring group from the Boc group to a thiazole carbonyl unit significantly improved the efficiency of the Bose-Mitsunobu azidation.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2023)
Article
Immunology
Jinghua Lu, Matthew Spencer, Zhongcheng Zou, Maria Traver, Joseph Brzostowski, Peter D. Sun
Summary: Understanding the molecular mechanism of Fc gamma R and IgG antibody binding is crucial for therapeutic antibody engineering. This study reveals that the FG loop-Fc interaction and the pH-sensing function of the D2 domain are critical for high affinity binding. The findings provide insights into antigen delivery, emphasize the importance of Fc glycan in high affinity antibody binding, and have implications for future antibody engineering.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Alicia Bauduin, Marion Papin, Aurelie Chantome, Helene Couthon, Laure Deschamps, Jose Requejo-Isidro, Christophe Vandier, Paul-Alain Jaffres
Summary: Three bioactive pyrene-based fluorescent analogues of Ohmline were synthesized, with OP2 and OP3 readily integrating into liposomes. Among them, only OP2 was able to reduce SK3 currents and inhibit SK3-dependent cancer cell migration. OP2 also showed rapid integration into bio-membranes.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yun Qian, Jun Zhang, Rui Xu, Qiang Li, Qi Shen, Guofu Zhu
Summary: The study developed pH-sensitive nanoparticles for breast cancer therapy, achieving significant tumor inhibiting effect by combining exogenous chemotherapeutics with endogenous ROS and LMWH to hinder breast cancer metastasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Jiali Li, Xue Jiang, Lihuan Shang, Zhen Li, Conglian Yang, Yan Luo, Daoyu Hu, Yaqi Shen, Zhiping Zhang
Summary: The study successfully synthesized L-epigallocatechin gallate complexed Mn2+ nanoparticles with good biocompatibility, stability, pH sensitivity, and anti-tumor properties, potentially serving as an MRI contrast agent.
Article
Pharmacology & Pharmacy
Takashi Nakamura, Taisei Nakade, Koharu Yamada, Yusuke Sato, Hideyoshi Harashima
Summary: The development of CL1H6-LNP offers a promising approach for efficient gene silencing in NK-92 cells with low cytotoxicity. The results suggest that CL1H6-LNP has the potential for delivering siRNA to NK-92 cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Biochemistry & Molecular Biology
Anca-Dana Bendrea, Luminita Cianga, Gabriela-Liliana Ailiesei, Demet Goen Colak, Irina Popescu, Ioan Cianga
Summary: This paper reports the synthesis of a new oligo(2-methyl-2-oxazoline) (OMeOx)-containing thiophene macromonomer and its versatile functional properties. The self-assembled structures formed by this macromonomer in water showed concentration-dependent fluorescence emission and excitation-dependent luminescence. The behavior of this material resembles that of polypeptides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Biomedical
Siddhi Gupta, Deepak Kumar Mishra, Mehak Zahoor Khan, Varsha Saini, Devashish Mehta, Sandeep Kumar, Aditya Yadav, Madhurima Mitra, Parul Rani, Mukesh Singh, Chayan Kanti Nandi, Prasenjit Das, Vineet Ahuja, Vinay Kumar Nandicoori, Avinash Bajaj
Summary: This study presents a fluorescent probe, P4, that can specifically detect mycobacterium species with high sensitivity and specificity. Unlike other enzyme-dependent probes, P4 probe can detect mycobacteria even in fixed mouse and human tissue. Therefore, P4 probe has potential applications in the diagnosis and prognosis of tuberculosis.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Biophysics
Hongyan Zhang, Ji Li, Rong Yuan, Yufen Li, Yue Zhang, Xiaoyun Hu, Jiqiang Qu, Yu Chen, Zheran Wang, Mingyu Xia, Dongkai Wang
Summary: A valid strategy for delivering natural drug Hol has been proposed, using a non-toxic degradable pH-sensitive polymer and Folate-DSPE-PEG2000 outer layer to efficiently inhibit the migration and invasion of breast cancer cells while targeting tumor sites. This drug delivery system demonstrated marked anti-tumor and lung metastasis suppression effects in mice models, with elevated apoptosis levels and repression of metalloproteinase expression.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Sarigama Rajesh, Sheeana Gangadoo, Han Nguyen, Jiali Zhai, Chaitali Dekiwadia, Calum J. Drummond, James Chapman, Vi Khanh Truong, Nhiem Tran
Summary: This study presents a novel approach using pH-sensitive lipid nanoparticles to deliver fluconazole and effectively inhibit the growth of resistant Cryptococcus neoformans. The nanoparticles change their structure and charge in response to the acidic environment, facilitating their interaction with the fungal cell wall. This targeted antifungal therapy represents a significant advancement in combating fungal antimicrobial resistance.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Sarigama Rajesh, Sheeana Gangadoo, Han Nguyen, Jiali Zhai, Chaitali Dekiwadia, Calum J. Drummond, James Chapman, Vi Khanh Truong, Nhiem Tran
Summary: This study presents a novel approach to improve the delivery of antifungal agent and combat the resistance of Cryptococcus neoformans. By encapsulating the agent in pH-sensitive lipid nanoparticles, the growth of resistant C. neoformans is inhibited. The nanoparticles exhibit different structures and charges at neutral and acidic pH, facilitating interaction with the fungal cell wall and leading to a significant decrease in the minimum inhibitory concentration of the agent. Microscopic observations support these findings, showing distortion and efflux of cytoplasmic molecules in fungal cells exposed to the nanoparticles. This represents a significant advancement in targeted antifungal therapy for combating resistance.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Polymer Science
Muhammad Akhlaq, Abul Kalam Azad, Inam Ullah, Asif Nawaz, Muhammad Safdar, Tanima Bhattacharya, A. B. M. Helal Uddin, Syed Atif Abbas, Allan Mathews, Sukalyan Kumar Kundu, Mireia Mallandrich Miret, H. C. Ananda Murthy, H. P. Nagaswarupa
Summary: The study aimed to develop and assess Gel/PVA hydrogels as a pH-sensitive matrix for delivering methotrexate to the colon. Various evaluations and analyses confirmed the potential application of these hydrogels as drug delivery systems for controlled release of methotrexate to the colon.
Article
Polymer Science
Fereshteh Arjmand, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani
Summary: A novel compound, 1,2-bis[(E)-4-(allyloxy)benzylidene]hydrazine, prepared via allyloxylation reaction, serves as a pH-labile crosslinker for drug carrier synthesis. The pH-responsive carriers enabled active delivery of anticancer drugs in cancerous tissues, showing excellent cumulative drug release, particularly at pH = 1.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Polymer Science
Qin Zhang, Xinying Yang, Yifang Wu, Chang Liu, Hongmei Xia, Xiaoman Cheng, Yongfeng Cheng, Ying Xia, Yu Wang
Summary: The aim of this study was to prepare and evaluate kaempferol-loaded carbopol polymer hydrogel, investigate its antioxidant activity, and compare drug release under different pH conditions.
Review
Chemistry, Multidisciplinary
Dan He, Yawen Li, Fuwen Zhao, Yuze Lin
Summary: High trap density in organic solar cells leads to localized charge carriers and reduced carrier lifetime, limiting device efficiency. This feature article summarizes the recent advances of trap suppression by material design and device engineering.
CHEMICAL COMMUNICATIONS
(2024)
Review
Chemistry, Multidisciplinary
Olivier Monfort, Arshitha Madhusudhan, Martin Motola
Summary: This article presents the advantages of coupling photocatalysis and Fenton-based processes for environmental remediation and discusses their synergy. It critically examines the simultaneous triggering of these two processes and provides insights into research approaches. The study aims to enhance understanding of this complex process and highlight the potential integration of new catalysts in current wastewater treatment technology.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Manideepa Dhar, Chittaranjan Mishra, Avijit Das, Uttam Manna
Summary: An approach of 'polymerization of monomers in its aggregated form' has been introduced to tailor the water wettability of fibrous and porous substrates, achieving hydrophobicity to superhydrophobicity transition, as well as patterned wettability. This facile chemical method provides a durable coating with adjustable and patterned wettability for various potential applications.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Saswat Ranjan Bhoi, Chhanda Debnath, Shikha Gandhi
Summary: In this article, a novel catalytic reaction using Pd(0) and Bronsted acid is reported for the synthesis of biologically important imidazolidinone-fused N-heterocycles through redox-neutral intramolecular N-allylation of indoles and pyrroles with alkynes. This atom-economical method is applicable to a wide range of substrates and eliminates the need for leaving groups or oxidizing agents commonly used in traditional allylation reactions.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Longkun Chen, Mingshuai Zhang, Meichen Liu, Zhuoyuan Liu, Yuetong Qiu, Zhilai Zhang, Fuchao Yu, Jiuzhong Huang
Summary: In this study, an efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as the sole coupling partner was demonstrated. Fused benzodiazepine skeletons were obtained in excellent yields, providing an improved approach to dual C-H unsymmetrical functionalization.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Alice Kennett, Sven Epple, Gabriella van der Valk, Irene Georgiou, Evelyne Gout, Romain R. Vives, Angela J. Russell
Summary: This study presents the design and synthesis of sulfated disaccharide inhibitors based on IdoA(2S)-GlcNS(6S), which showed potent inhibition of Sulf-2. The results suggest that IdoA(2S)-GlcNS(6S) is the shortest fragment size required for effective inhibition of Sulfs, and a trisulfated disaccharide is identified as the minimal fragment size of heparan sulfate for effective endosulfatase inhibition.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Mauro Garbini, Andrea Brunetti, Riccardo Pedrazzani, Magda Monari, Massimo Marcaccio, Giulio Bertuzzi, Marco Bandini
Summary: The self-adaptability of galvanostatic electrolysis was found to be helpful in a multistage chemo- and diastereoselective electrochemically promoted cyclodimerization of chalcones. Through a series of reductive events, densely functionalized cyclopentanes with five contiguous stereocenters were obtained (25 examples, yields up to 95%, dr values up to >20:1). Further experimental and electrochemical investigations indicated the crucial role of dynamic kinetic resolution of the aldol intermediate in the reaction mechanism.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Dhananjay S. Nipate, Neha Meena, Prakash N. Swami, Krishnan Rangan, Anil Kumar
Summary: In this study, the synthesis of functionalized benzo[a]phenazines and indazolo[2,3-a]quinolines was achieved through Rh(III)-catalyzed oxidative annulation of 2-arylquinoxalines and 2-aryl-2H-indazoles with allyl alcohols. The method showed a wide substrate scope, excellent functional group tolerance, good to high yields of annulated products, and the capability for scaled-up synthesis. A tentative mechanism of the annulation reaction was proposed based on a preliminary mechanistic investigation.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Ruonan Zhang, Abudukadi Tudi, Xia Yang, Xuping Wang, Zhihua Yang, Shujuan Han, Shilie Pan
Summary: A new lead tellurium borate material with a unique fundamental building block [B4O10] was synthesized and found to exhibit high birefringence. The structure-property relationship was discussed using first-principles calculations.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Amresh Kumar Singh, Baishali Thakurta, Anupam Giri, Monalisa Pal
Summary: This study introduces three key concepts for the quick synthesis of large-scale high-quality 2D materials films and their utilization in device fabrication.
CHEMICAL COMMUNICATIONS
(2024)
Article
Chemistry, Multidisciplinary
Reina Hagiwara, Shun Nishimura, Kosuke Okeyoshi
Summary: A copolymer-conjugated nanocatalytic system has been developed to improve electron transfer and enhance photoinduced H2 generation.
CHEMICAL COMMUNICATIONS
(2024)