Article
Oncology
Mengkai Yang, Tao Zhang, Yangfeng Zhang, Xiaojun Ma, Jing Han, Ke Zeng, Yafei Jiang, Zongyi Wang, Zhuoying Wang, Jing Xu, Yingqi Hua, Zhengdong Cai, Wei Sun
Summary: The study revealed that MYLK4 promotes the growth and metastasis of osteosarcoma by activating the EGFR signaling pathway. Additionally, the combination of MYLK4 and EGFR inhibitors showed synergistic effects on the growth and metastasis of OS in vitro and in vivo.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biology
Yongjian Huang, Jana Ognjenovic, Deepti Karandur, Kate Miller, Alan Merk, Sriram Subramaniam, John Kuriyan
Summary: Research has shown that the EGFR receptor can adopt different conformations of the extracellular module when binding to different ligands, with implications for intracellular signaling pathways.
Article
Multidisciplinary Sciences
Brendan Sullivan, Taylor Light, Vinh Vu, Adrian Kapustka, Kalina Hristova, Deborah Leckband
Summary: This study reveals a force-transduction mechanism that connects mechanical perturbations of E-cadherin to the activation of EGFR, a key regulator of cell proliferation. The results demonstrate that E-cadherin and EGFR form complexes at the plasma membrane, which are disrupted by the application of force or the presence of EGF. The findings provide insights into the initial steps of E-cadherin-mediated force transduction and the activation of growth regulatory signaling cascades.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Pharmacology & Pharmacy
Jazlyn P. Borges, Katrina Mekhail, Gregory D. Fairn, Costin N. Antonescu, Benjamin E. Steinberg
Summary: Chronic pain is a major public health issue that is often resistant to conventional analgesics. Recent studies have implicated the epidermal growth factor receptor (EGFR) signaling pathway in chronic pain, suggesting potential therapeutic targets for this devastating condition.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sixolile Centane, Sithi Mgidlana, Yolanda Openda, Tebello Nyokong
Summary: This study investigates the role of biointerface design in the development of an impedimetric biosensor for electrochemical detection of human epidermal growth factor receptor 2 (HER2). Two novel cobalt phthalocyanines are compared as signal amplifiers and immobilization platforms for the HB5 aptamer. The aptasensors show low limit of detection values with high sensitivity and stability, even in human serum samples, demonstrating great potential for improved monitoring of HER2 levels in breast cancer management.
BIOELECTROCHEMISTRY
(2022)
Review
Cell Biology
Joanne L. Peterson, Brian P. Ceresa
Summary: Maintaining proper structure and function of the cornea is essential for clear vision. The epidermal growth factor receptor (EGFR) plays a crucial role in maintaining and restoring the corneal epithelium. Recent advances in understanding EGFR signaling and trafficking offer new strategies to overcome receptor desensitization and optimize receptor signaling for corneal health.
Article
Gastroenterology & Hepatology
Juhoon So, Minwook Kim, Seung-Hoon Lee, Sungjin Ko, Daniel A. Lee, Hyewon Park, Mizuki Azuma, Michael J. Parsons, David Prober, Donghun Shin
Summary: The differentiation of liver progenitor cells (LPCs) into hepatocytes is crucial for reducing inflammation and fibrosis in chronic liver diseases. Inhibition of the epidermal growth factor receptor (EGFR) signaling pathway promotes LPC-to-hepatocyte differentiation and may serve as a proregenerative therapeutic approach for patients with advanced liver disease. This study provides insights into the mechanisms underlying LPC-mediated liver regeneration and suggests the potential of EGFR inhibitors as a treatment option.
Article
Materials Science, Multidisciplinary
Mihaela Baibarac, Monica Daescu, Szilard N. Fejer
Summary: This study used Raman scattering and FTIR spectroscopy to report new optical evidence for the assembly of sensors based on RGO and PDPA for detecting EGFR. The chemical mechanism of the assembly process for this sensor was proposed based on changes in Raman scattering and FTIR spectroscopy. Preliminary testing of the sensors based on RGO and PDPA was conducted using cyclic voltammetry.
Article
Biochemistry & Molecular Biology
Soo Hee Lee, Seong-Chun Kwon, Seong-Ho Ok, Seung Hyun Ahn, Sung Il Bae, Ji-Yoon Kim, Yeran Hwang, Kyeong-Eon Park, Mingu Kim, Ju-Tae Sohn
Summary: In this study, the researchers investigated the involvement of aortic contraction induced by dexmedetomidine in the transactivation of EGFR in endothelium-denuded rat aortas. They found that the activation of alpha-2 adrenoceptor, Src kinase, and matrix metalloproteinase mediated the contraction and subsequent JNK phosphorylation and increased calcium levels. These findings provide insights into the cellular mechanisms underlying dexmedetomidine-induced effects on aortic contraction and EGFR transactivation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Kyung-Jong Won, Rami Lee, Sun-Hye Choi, Ji-Hun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Summary: This study aimed to elucidate the involvement of EGFRs in gintonin-induced wound repair in HaCaT keratinocytes. Results showed that gintonin increased EGF receptor activation, as well as promoted proliferation and migration in HaCaT cells. Additionally, gintonin stimulated the expression and release of HB-EGF. These findings suggest a close relationship between gintonin's wound-healing effects and the collaboration of EGF receptor activation and HB-EGF release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dermatology
Ikbal Esen Aydingoz, Gulsen Tukenmez Demirci, Deniz Agirbasli, Devrim Oz-Arslan, Guven Yenmis
Summary: The study revealed a significant increase in the amount of EGF in acne patients, indicating a potential role of EGF in the pathogenesis of acne.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Oncology
Daichi Fujimoto, Hiroaki Akamatsu, Takeshi Morimoto, Kazushige Wakuda, Yuki Sato, Yoshitaka Kawa, Toshihide Yokoyama, Motohiro Tamiya, Ryota Hiraoka, Naoki Shingu, Hideki Ikeda, Akihiro Tamiya, Masaki Kanazu, Eisaku Miyauchi, Satoru Miura, Masaaki Yanai, Makiko Yomota, Ryotaro Morinaga, Takashi Yokoi, Akito Hata, Hidekazu Suzuki, Hirotaka Matsumoto, Shinya Sakata, Naoki Furuya, Yuhei Harutani, Ichiro Nakachi, Ayumu Otsuki, Shinya Uematsu, Satoshi Hara, Keiki Yokoo, Takeya Sugimoto, Nobuyuki Yamamoto
Summary: This study aimed to determine the incidence and clinical course of histologic transformation (HT) in lung cancer patients with epidermal growth factor receptor (EGFR) mutations. The study found that approximately 3% of EGFR-mutated patients developed HT after acquiring resistance to EGFR-tyrosine kinase inhibitors (TKIs). There was no significant difference in survival between patients with transformation to high-grade neuroendocrine carcinoma and those with transformation to another subtype of non-small cell lung cancer. Cytotoxic agents were likely to be effective in patients with HT, while the effectiveness of immune checkpoint inhibitors was limited.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Barbara Schreier, Virginie Dubourg, Stefanie Huebschmann, Sindy Rabe, Sigrid Mildenberger, Michael Gekle
Summary: The study reveals that EGFR and AT1R synergistically regulate gene expression, leading to qualitative, quantitative, and temporal changes, potentially impacting cell stress and vascular biology. Synergistic activation of SRF via distinct pathways and transcription factors AP1 and EGR plays a key role in this process.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Wei Yin, Ke Zhang, Qinghua Deng, Qingqing Yu, Yanjiao Mao, Ruping Zhao, Shenglin Ma
Summary: The study showed that AZD3759 had superior inhibitory effects on glioma compared to osimertinib, possibly through a synergistic blockade of the EGFR and JAK/STAT signaling pathways, suggesting its potential as a promising treatment strategy for glioma.
Article
Multidisciplinary Sciences
Yuan Yang, Ruizeng Luo, Shengyu Chao, Jiangtao Xue, Dongjie Jiang, Yun Hao Feng, Xin Dong Guo, Dan Luo, Jiaping Zhang, Zhou Li, Zhong Lin Wang
Summary: This article introduces a microneedle-based self-powered transcutaneous electrical stimulation system (mn-STESS), which can improve the pharmacodynamics of epidermal growth factor and overcome the pharmacodynamic challenges associated with its conventional administration strategies.
NATURE COMMUNICATIONS
(2022)
Article
Business
Sanjay Kumar Singh, Manlio Del Giudice, Charbel Jose Chiappetta Jabbour, Hengky Latan, Amrik Singh Sohal
Summary: Stakeholder pressure can influence green dynamic capabilities and green innovation, ultimately affecting firm performance. Furthermore, green dynamic capabilities mediate the relationship between stakeholder pressure and green innovation.
BUSINESS STRATEGY AND THE ENVIRONMENT
(2022)
Article
Business
Alberto Ferraris, William Y. Degbey, Sanjay Kumar Singh, Stefano Bresciani, Sylvaine Castellano, Fabio Fiano, Jerome Couturier
Summary: This study examines the individual-level microfoundations of subsidiary CEOs in emerging markets as antecedents of the strategic agility of multinational enterprises, and examines subsidiary embeddedness as a key organizational-level moderator of these relationships. The findings suggest that the tenure and overall experience of subsidiary CEOs in emerging markets, as well as their cognitive characteristics, positively affect MNE strategic agility. Additionally, subsidiary embeddedness moderates these relationships in different ways, providing opportunities for new managerial and theoretical considerations.
JOURNAL OF WORLD BUSINESS
(2022)
Article
Engineering, Multidisciplinary
Anurag Pathak, Manoj Kumar, Sanjay Kumar Singh, Umesh Singh, Manoj Kumar Tiwari, Sandeep Kumar
Summary: This article addresses the estimation problem in step-stress partially accelerated life test of Maxwell Boltzmann distribution, considering progressive type-II censoring with binomial removals. The maximum likelihood and Bayes estimators of the parameter are derived under symmetric and asymmetric loss functions. Furthermore, the performance of these estimators is compared based on risks. The proposed methodology is illustrated using the time to failure of Aluminium reduction cells and survival times of male rats exposed to high radiation levels in weeks.
INTERNATIONAL JOURNAL OF SYSTEM ASSURANCE ENGINEERING AND MANAGEMENT
(2022)
Review
Chemistry, Medicinal
Aiswarya Chaudhuri, Dulla Naveen Kumar, Deepa Dehari, Sanjay Singh, Pradeep Kumar, Pradeep Kumar Bolla, Dinesh Kumar, Ashish Kumar Agrawal
Summary: This article discusses the treatment strategies for triple-negative breast cancer, introduces the application of nanotechnology to enhance the efficacy of drug therapy, and overcome the limitations of conventional chemotherapy and targeted therapy.
Article
Business
Bader K. AlNuaimi, Sanjay Kumar Singh, Shuang Ren, Pawan Budhwar, Dmitriy Vorobyev
Summary: Drawing upon new institutional theory, this study examined the influence of digital transformational leadership and organizational agility on digital transformation, revealing their positive effects and the mediating role of organizational agility in the relationship between leadership and transformation. These findings contribute to a deeper understanding of the impact of transformational leadership and organizational agility on digital transformation, as well as the role of digital strategy in this process.
JOURNAL OF BUSINESS RESEARCH
(2022)
Article
Business
Madhusmita Panda, Rabindra Kumar Pradhan, Sanjay Kumar Singh
Summary: This study applied goal-setting theory to investigate the impact of organizational culture on the psychological empowerment and job performance of organizationally assigned expatriates. It also explored the moderating role of host country language ability in this relationship.
JOURNAL OF BUSINESS RESEARCH
(2022)
Article
Management
Ranya Saeed Alhumoudi, Sanjay Kumar Singh, Syed Zamberi Ahmad
Summary: Perceived corporate social responsibility has a positive impact on passionate attitudes towards work and mediates the relationship between perceived CSR and innovative work behavior. The study suggests mixed-method investigations for future research and emphasizes the importance of engaging in CSR activities for organizations. Passionate Gen Y nurses play a valuable role in improving patient care services through innovative work behavior.
INTERNATIONAL JOURNAL OF ORGANIZATIONAL ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Sanjeev Meena, Radheshyam Sharma, Sanjay Kumar Singh, Ashish Kumar, R. Shiv Ramakrishnan, Stuti Sharma, G. K. Koutu, Lokesh Gaur
Summary: This study characterized the genetic diversity of farmers' varieties in central India using SSR markers and blast-linked markers. The results showed clear geographical discrimination among the varieties and the presence of multiple blast resistance genes, which could be utilized in future breeding programs.
JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Article
Computer Science, Information Systems
Durgesh Singh, Sanjay K. Singh, Sandeep Sambhaji Udmale
Summary: In this paper, a self-embedding block-wise fragile image watermarking scheme is proposed for authentication, localization, and recovery with enhanced accuracy. The scheme splits the cover image into non-overlapping blocks and calculates restoration and authentication bits from the MSBs planes. The proposed scheme achieves high-quality restoration and significant authentication possibilities for each block, with high Peak Signal to Noise Ratio and Normalized Correlation Coefficient up to 50% tampering rate.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Article
Medicine, General & Internal
Jeremy J. Hoffman, Reena Yadav, Sandip Das Sanyam, Pankaj Chaudhary, Abhishek Roshan, Sanjay K. Singh, Sailesh K. Mishra, Simon Arunga, Victor H. Hu, David Macleod, Astrid Leck, Matthew J. Burton
Summary: This study describes the health-seeking journey for patients with microbial keratitis in Nepal and identifies factors associated with delay.
FRONTIERS IN MEDICINE
(2022)
Article
Microbiology
Shiwali Rana, Sanjay Kumar Singh, Laurent Dufosse
Summary: This study reveals the correct identification of Indian Fusarium isolates and their potential for BEA production through multigene phylogeny. It also suggests their possible applications in medicine, agriculture, and industry.
Article
Green & Sustainable Science & Technology
Ashish Malik, Sanjay Kumar Singh
Summary: An experimental program was conducted to determine the dynamic properties of pond ash and the effects of additives such as crumb rubber and coir fiber. The results showed that crumb rubber improved the liquefaction resistance of pond ash, while coir fiber had no significant effect on it. The dynamic shear modulus of pond ash decreased when mixed with crumb rubber, but increased significantly when mixed with coir fiber.
JOURNAL OF RENEWABLE MATERIALS
(2023)
Article
Energy & Fuels
Ab Quyoom Seh, Dinesh C. Gupta
Summary: This study investigated the quaternary Heusler alloy CoZrMnAs using the Wein2k simulation code based on density functional theory. The results showed that CoZrMnAs has a stable structure and ferromagnetic nature, and exhibits half-metallic properties, making it suitable for waste heat recovery.
Review
Biotechnology & Applied Microbiology
Rana Shiwali, Singh Sanjay Kumar
Summary: This review provides comprehensive information on beauvercin, including its biosynthetic pathway and various bioactivities. Beauvercin shows antimicrobial, insecticidal, and anticancer properties, but its genotoxicity should also be taken into consideration. For researchers, this documentation serves as an important reference for optimizing and enhancing beauvericin production.
RESEARCH JOURNAL OF BIOTECHNOLOGY
(2022)
Proceedings Paper
Materials Science, Multidisciplinary
Deepak Kumar Sharma, Nikimoni Das, Sanjay Kumar Singh, Krishna Murari Pandey
Summary: The main objective of this research is to experimentally evaluate the performance of triple concentric tube heat exchangers under steady-state conditions. Water is used as the working fluid and is circulated at different temperatures. The study investigates the variation of fluid temperature along the length of the heat exchanger and the relationship between friction factor, Nusselt number, and Reynolds number. The experimental results show that the counter-current arrangement performs the best.
MATERIALS TODAY-PROCEEDINGS
(2022)
Article
Biochemistry & Molecular Biology
Ali Mehri, Karim Mahnam, Hajar Sirous, Mahmoud Aghaei, Leila Rafiei, Mahboubeh Rostami
Summary: One potential approach for tumor therapy is inhibiting the binding between MDM2 and p53 to reactivate p53 in tumor cells. In this study, Monastrol derivatives were designed as MDM2 inhibitors and evaluated for their cytotoxicity on cancer cells. Compound 5d showed the best inhibitory results in silico and in vitro experiments. These findings suggest that Monastrol derivatives have the potential to be candidates for MDM2 inhibition.
CHEMICAL BIOLOGY & DRUG DESIGN
(2024)
