Bile Salts at Low pH Cause Dilation of Intercellular Spaces in In Vitro Stratified Primary Esophageal Cells, Possibly by Modulating Wnt Signaling

Bile Acid at Low pH Reduces Squamous Differentiation and Activates EGFR Signaling in Esophageal Squamous Cells in 3-D Culture

(2013) Sayak Ghatak et al.   JOURNAL OF GASTROINTESTINAL SURGERY

Esophageal barrier function and tight junction expression in healthy subjects and patients with gastroesophageal reflux disease: functionality of esophageal mucosa exposed to bile salt and trypsin in vitro

(2013) Eleonora Victoria Charlotta Björkman et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Isolation and characterization of mouse and human esophageal epithelial cells in 3D organotypic culture

(2012) Jiri Kalabis et al.   Nature Protocols

Refractory Heartburn: Comparison of Intercellular Space Diameter in Documented GERD vs. Functional Heartburn

(2010) Marcelo F Vela et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

The role of an alginate suspension on pepsin and bile acids - key aggressors in the gastric refluxate. Does this have implications for the treatment of gastro-oesophageal reflux disease?

(2010) Vicki Strugala et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Dilated intercellular spaces and chronic cough as an extra-oesophageal manifestation of gastrooesophageal reflux disease

(2010) Roy C. Orlando   PULMONARY PHARMACOLOGY & THERAPEUTICS

Molecular Bases of Cell-Cell Junctions Stability and Dynamics

(2009) M. Cavey et al.   Cold Spring Harbor Perspectives in Biology

Acid, Bile, and CDX: the ABCs of making Barrett's metaplasia

(2008) Rhonda F. Souza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation

(2008) Francesco Raimondi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Bile Acids: Chemistry, Pathochemistry, Biology, Pathobiology, and Therapeutics

(2008) A. F. Hofmann et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces

(2008) R Farre et al.   GUT

In GERD patients, mucosal repair associated genes are upregulated in non-inflamed oesophageal epithelium

(2008) D. R. de Vries et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE